Gladden Longevity Podcast -- formerly Living Beyond 120

Join Dr. Jeffrey Gladden in this wonderful conversation with Doni Wilson, a leading expert in hormones and epigenetics. Dr. Doni is a naturopathic doctor, certified professional midwife, and certified nutrition specialist with over two decades of experience helping patients reverse challenging health conditions like fatigue, anxiety, autoimmunity, fertility, MTHFR, and HPV. In the process of solving her migraines, Dr. Doni developed her signature, proven Stress Recovery Protocol™, which identifies how stress uniquely affects each individual and then uses epigenetics to reoptimize health. This episode talks about stress, anxiety, depression, and their impact on health. They also talk about how stress is mastered instead of managed, how to reset your health, and the kind of healing that is truly foundational to crack the code on longevity.    Show notes:    Dr. Gladden welcomes Doni Wilson, and Doni talks about how she got into what she does. (1:44)  Doni tells us how she researched how stress affects women during pregnancy and labor. (3:43)  Doni explains how adrenaline and cortisol actually assist the body to function optimally. (5:20)  Dr. Gladden elaborates on the types of stress that can stimulate longevity. (7:21)  Dr. Gladden brings up the relationship between stress and not feeling safe. (9:40)  Doni notes that if cortisol or adrenaline are imbalanced, stress cannot be mastered. (12:38)  Doni tells us what we need to know about our bodies, to be able to provide the proper treatment for ourselves. (14:16)  Doni talks about the benefits of testing cortisol at different times throughout the day. (16:56)  Doni introduces us to the patterns she developed called “the stress types”. (18:55)  Doni recounts how she helped her adrenal glands recover and find optimal levels, and tells us what things we can do daily to help us optimize ours. (21:30)  Dr. Gladden asks about heart rate variability and describes it as another window to stress. (24:05)  Doni notes how heart rate variability information helps us make the right decisions. (27:55)  Doni goes through how she uses food sensitivity panels. (30:25)  Dr. Gladden explains how stress in mothers could affect children’s life expectancy. (33:20)  Doni talks about the Incas and their three-level approach to full health and balance as individuals who are also a part of something bigger. (35:50)  Dr. Gladden speaks about how people with spiritual connections and beliefs heal faster. (39:26)  Doni brings up the power that psychedelics have to give us a birds-eye-view of our lives and a fresh perspective. (43:20)  Doni cites how she explores different possibilities in her book. (46:29)  Doni gives her takeaways for listeners who want to optimize their longevity. (51:22)  Dr. Gladden elaborates on how giving yourself love and safety, will actually spread out to other people and drip down your generational lineage to expand that healing everywhere. (54:00)     Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well.  Follow us on social media!  Instagram: @gladdenlongevitypodcast  Twitter: @GLPodcast_  Facebook: @GladdenLongevityPodcast     To reach out to Dr. Doni and/or learn more about her and her incredible work/book:  https://doctordoni.com/  IG: @drdoniwilson  TW: @glutenfreedoc  FB: Dr. Doni Wilson, ND  YT: Dr. Doni Wilson  And to take her stress type quiz, go here: https://doctordoni.com/quiz/stress-quiz/ 

Join Dr. Jeffrey Gladden in this chat with Gary Richter, one of the top ten veterinarians in the United States for 2012, and America’s Favorite Veterinarian in 2015 by the American Veterinary Medical Foundation (AVMF). Gary is a graduate of the University of Florida with a B.S. in animal science, an M.S. in veterinary medical science, and a doctorate of veterinary medicine with honors. He launched Holistic Veterinary Care in 2009 (in Oakland, California), is certified in veterinary acupuncture and veterinary chiropractic, and uses these therapies along with his veterinary medical education to achieve better outcomes for his patients. In this episode, they talk about how pet owners can use longevity science and practices to extend the lifespan and healthspan of their pets, the things you can easily do at home that will make a huge difference in your pet's health immediately and in the long run, and which traditional practices to stay away from. If you're going to live longer, you'll want your pet to do that with you.    Show notes: 00:55 Dr. Gladden introduces the episode's guest and topic. 02:14 Dr. Gladden asks what are some of the things people can do that have an impact on the health and longevity of their pets. 02:38 Gary explains why this is not only an animal health and welfare issue but also a human health issue. 03:37 Dr. Gladden brings up the Life Energy circle in our Mosaic of Ages and the role that pets could play in that. They proceed to elaborate on the unconditional element of this kind of connection and the profound effects it can have in a person's well-being. 06:27 What are some of the things people are doing wrong, though well-intended? 06:50 Gary tells us what is the single biggest thing we can do to help our pet live a better life. 07:34 Gary explains what's wrong with regular dry and canned food for pets. 08:27 Gary recalls what he was taught in school about pet nutrition, which is part of the problem. 08:50 So, what is the solution? Gary introduces “biologically appropriate food”. 10:04 Dr. Gladden asks for clarification on what a “whole food diet” looks like for pets. 12:13 Gary classifies dogs and cats in appropriate carnivore-omnivore categories. 13:12 Gary clarifies what dogs actually need in their food and what's not necessary. 14:05 Dr. Gladden raises the question of variety in our pet's diet. 14:56 Gary mentions the two things to keep in mind to work on a balanced diet for our pets. 15:41 How do we figure out if we're giving them a balanced diet? Gary give us guidance. 16:59 Where do we get this kind of food? And how do we choose between our options? 18:41 Gary lists out some nationally available brands. 19:54 Dr. Gladden talks about food acting as medicine or poison both for pets and people. 20:06 Dr. Gladden and Gary go into the costs of feeding our pets with regular dry or canned food vs whole foods. 21:41 Dr. Gladden asks Gary if dogs should NEVER eat regular dry or canned food. 22:36 Gary explains the greatest advantage that pets have over humans in terms of keeping a healthy balanced diet. This is the power that we have. 23:10 Dr. Gladden elaborates on the power of constructing the environment to support the mission. 24:50 Gary talks about table scraps and things we definitely want to keep away from our dogs. 26:35 Gary explains why chocolate is more problematic now than it was a while ago. 27:46 Dairy in our pets' diet is discussed. 28:50 What happens when you get a dog or a cat off kibble and onto a fresh food diet? 29:56 Dr. Gladden asks if giving pets nutrient-dense food has the same effects, in terms of satiation, weight loss, etc., as it does in humans. 30:26 Gary clarifies what “meat for dogs” extends to and the level of nutrition there. 31:47 Gary and Dr. Gladden discuss tripe: what it is and the ways you can feed it to your dog. Do they like it? 33:00 Dr. Gladden brings up the aging process in animals and asks Gary to elaborate. Is the seven years per one human year thing true? 34:30 Gary tells us what is the real key to promoting longevity in our pets. 35:32 Not all exercise will be of benefit to our dogs in the long run. Gary explains why. 37:51 Is there a way to rehab our dogs from those activities that give them joy but might be detrimental to their health? Dr. Gladden asks. 39:23 Gary and Dr. Gladden discuss the idea of maybe putting together a cocktail of peptides to help our very active pets heal and regenerate, as well as working dogs. 41:39 Gary and Dr. Gladden talk about figuring out how to give our dogs hydrogen water or something similar to help them recover, and the possibility of future projects together. 43:43 Dr. Gladden explains what he's measuring in humans right now, the breakthroughs that he's having and talks about maybe setting up that kind of trial for animals. 44:37 Dr. Gladden asks Gary how we can help prevent age-related diseases in our pets. 45:42 Gary talks about different kinds of diseases and the different kinds of dogs that tend to develop them. 46:55 Gary brings up research showing a relationship between certain types of cancer and spaying/neutering. Him and Dr. Gladden elaborate on the possible effects of spaying/neutering in pets' health in the long run. 49:52 There is a physiologic difference in dogs that were spayed/neutered at a younger age. 50:57 What is routinely recommended in veterinary medicine that might or might not be good for your pet? 53:00 Gary talks vaccines and the practice of over vaccinating our pets. 54:34 How to avoid over vaccination. Gary explains his method. 56:17 Gary explains the danger with parvo. 57:18 Dr. Gladden asks for Gary's expert take on the vaccination topic in regards to cats. 59:01 Dr. Gladden asks about the kinds of diseases or infections that our pets could transmit to us. What could we be exposed to? 1:01:36 Gary gives out the different websites people can go to to get educated, connect with him, get nutritious food for their pets, and even scope out the new pet wearables he's coming out with.      For more information on our mission & approach to longevity, health & human performance optimization, how to become a client, or more details regarding this and other podcast episodes, visit our website: www.gladdenlongevity.com  Follow us on social media! Instagram: @gladdenlongevity  Twitter: @gladdenlongevit  Facebook: @GladdenLongevity    And for more information on Dr. Gary Richter, his practice, his ultimate pet health guide on nutrition, and pet wearables, visit his websites and social media pages!     https://drgaryrichter.com/   www.PetVetExpert.com   www.HolisticVetCare.com   www.MyPetThrives.com   www.UltimatePetNutrition.com   www.PetMetrics.com  IG: @petvetexpert / @holisticvetcare / @ultimatepetnutrition  TW: @petvetexpert / @ultpetnutrition   FB: Dr. Gary Richter  YT: Ultimate Pet Nutrition   

Join Dr. Gladden and Ian Mitchell on this conversation about Carbon60 and the wonders it can do in terms of optimizing your body's internal performance and overall health. Ian is an inventor, a biochemist, a pharmaceutical developer, and specializes in anti-aging. A research scientist who studied Chemistry (ACS Track) at Mississippi State University and Jazz Performance at the University of New Orleans, working with the type of people who want to experience superhuman performance, he has 25 years of experience making contributions across multiple fields. Over the past decade he has developed multiple novel therapeutics using Lipofullerenic-Conjugates and holds multiple patents in the field of nano-medicine. Additionally, he developed multiple products focused on the convergence of mobile telecommunications and biomedical engineering, as well as nanofluidic multi-assay systems for use with Lab-on-Chip (LoC) devices, and holds joint patents with the University of Tulsa for viral inhibitors. He was a lead fabrication consultant for NASA’s “ENDURANCE mission” project to Europa. Currently, he is the lead scientist at Biocharged and Wizard Sciences, Polymath in Residence at Ecliptic Capital, and head of R&D for Biochacked. Ian has managed to not only enhance energy production in the body but also increase its capacity from a sub-cellular level with Carbon60, as well as help it fight infection in the deepest way possible with a cocktail including this molecule that you will want to find out about.    Show notes: 00:55 Dr. Gladden gives a description of the episode's subject matter. 01:47 Dr. Gladden introduces Ian Mitchell and Carbon60. 02:42 Ian tells his personal story and journey towards his current endeavor with Carbon60. 05:21 Dr. Gladden interjects and explains what “p53 knockout” is for the audience. 05:56 Ian describes exactly what he did when testing the Carbon60 in vivo and the impressive results obtained, consequently, what he kept learning about the Carbon60 molecule. 07:06 Ian explains what Carbon60 can do inside the body. 07:43 Dr. Gladden explains exactly what this means in terms of function, how Carbon60 is counteracting the body's decline. 09:33 Ian describes how he started to study the body's process to create ATP (energy) in order to positively optimize it in every way without negatively interfering in any particular area. 10:15 This is how we get our 400hp motor back. 10:51 How do we replace the damaged parts that are not going to fix themselves? 10:57 Dr. Gladden gives a summary of what Ian is doing with Carbon60 in 3 parts. How it is optimizing mitochondrial function, what it is adding to the machinery, and how it is restoring the parts. 12:01 Ian shares his personal story with infection and describes how it affected his function greatly. 13:18 Ian tells what he had to do to get the correct diagnosis as to what was going on with him on a sub-cellular level to be able to heal himself. 14:31 Dr. Gladden asks if what he discovered is what people experiencing long term effects of infection around the globe right now might be suffering from after they stop showing signs of infection on a surface level. 15:10 Ian talks about the unexpected use of Benadryl to counteract this sub-cellular issue, coupled with Carbon60 and Urolithin A for full recovery assisted by mitophagy. 16:22 Dr. Gladden explains what the cell does during autophagy and mitophagy. 16:51 Ian explains how the body fights a virus and how he helped the body do this all the way to the sub-cellular level to truly heal. 18:23 Dr. Gladden asks if Ian has been adding Urolithin A to his products, and Ian describes what he has discovered by using himself as a guinea pig. 19:26 Ian talks about what he has done with the p53 knockout experiment to feel confident that there is some mechanism in his product that is suppressing oncological formations. 21:01 Dr. Gladden asks Ian what he thinks about the vaccine effects on mitochondria. 23:02 Ian talks about looking into very small embryonic-like stem cells, adding those to the procedure in his lab, and the resulting effects of it. How he got his capacity back. 23:55 Dr. Gladden takes the products that Ian has been using and groups them together in a trilogy. Ian further explains what the Benadryl's role is within the cocktail. 25:42 Dr. Gladden and Ian introduce the product that Ian has been working on that is stopping tumor cells from dividing. Ian explains how he has optimized it and what universities in Spain and USA have discovered in regards to cancer. This is how cancer cells work and what Ian is doing to interfere in their process. 31:16 Dr. Gladden asks if Ian is using a cocktail of things to do this or what things is he linking together as a strategy. 32:00 Ian goes on to list and explain the strategy and its elements. 33:21 Deterium-depleted water is introduced, which is another way of mitochondrial modulation. It's like higher octane fuel, Ryan explains. 35:45 Is there a way to take ordinary water and turn it into Deterium-depleted water? Dr. Gladden asks. 37:27 Ian tells us about the method he developed to produce Deterium-depleted water at a much more attainable price, solving the major current issue with it. 40:00 Dr. Gladden brings up the brain and Ian's NeuralRx product. Ian tells what this product was actually designed for, and Dr. Gladden talks about what they have found out in using it. 43:26 Ian explains exactly what NeuralRx does in the brain. 43:39 Dr. G interrupts to explain what the glymphatic system is to the audience and what it does. 45:40 What happens after a few weeks using NeuralRx? 46:44 What can you do to increase NeuralRx's capacity? 47:36 Dr. Gladden lists the benefits and capacities of Ian's products. 48:00 Ian describes what he has been accomplishing in preliminary testing with one of his experimental compounds. 48:36 Dr. Gladden tells the audience where they can find Ian's products and asks what is coming to market next. 49:44 Ian explains what he is trying to address exactly in terms of longevity. 51:26 Dr. Gladden asks Ian really how recovered he feels in his journey. 52:25 Dr. Gladden clarifies the kind of strategy they're going after to get the body all the way back to optimal health. 53:15 They say goodbye.    For more information on our mission & approach to longevity, health & human performance optimization, how to become a client, or more details regarding this and other podcast episodes, visit our website: www.gladdenlongevity.com  Follow us on social media!  Instagram: @gladdenlongevity  Twitter: @gladdenlongevit  Facebook: @GladdenLongevity    For Ian Mitchell's products, visit the Wizard Sciences' website: www.wizardsciences.com  Instagram: @wizardsciences  "As close as you'll feel to limitless"   

Join Dr. Gladden on this conversation with Ryan Smith about epigenetic age testing and DNA methylation. Ryan has a biochemistry degree from the University of Transylvania. He went to medical school and started clinical rotations before realizing he didn't want to be a doctor. That's when he pivoted to the world of pharmacy, focusing on peptide synthesis, and opened up Tailor Made Compounding. Ryan has been very successful in his endeavors, with Tailor Made Compounding becoming the 4th fastest growing healthcare company at the time, investing in several other functional medicine spaces and, eventually, starting TruDiagnostic. This is a CLIA certified lab and health data company focused and committed to research with over 30 approved clinical research studies investigating the epigenetic methylation changes of a variety of longevity and health interventions. They have created one of the largest private epigenetic health databases in the world with over 13,000 patients tested and continue to lead the space in epigenetic methylation interpretation and diagnostic prediction. In this episode, him and Dr. Gladden discuss how epigenetic age testing and DNA methylation have evolved, the different kinds of clocks that exist now and what they measure, as well as the advances being made and envisioned in the disease prevention and age reversal spaces.    Show notes:  00:55 Dr. Gladden gives a description of this episode and an introduction of Ryan Smith. 02:20 Dr. Gladden explains why he is excited for this show. 03:15 Ryan introduces the audience to TruAge and tells us the big takeaway from this testing. 04:50 What is epigenetic methylation? What are the two main epigenetic marks? Ryan explains our DNA's "on and off switches". 05:57 Dr. Gladden clarifies what is being measured exactly. 06:29 The concept of methylation clock is introduced by Dr. Gladden, and he explains how it keeps track of the aging process but also contributes to it. 07:11 Dr. Gladden asks if Ryan's company is measuring acetylation patterns as well. 07:17 Ryan talks about clinical trials where they are also measuring acetylation patterns and why it's proven not to be ready for prime time large-scale investigation. 08:20 Dr. Gladden asks if they're hitting a plateau in terms of accuracy with the amount of genes being tested. 09:02 Ryan explains why doubling the amount of genes being tested doesn't necessarily translate into a doubling of accuracy. 09:09 How are they getting an insight into the path of physiology? Ryan talks about seeing what is changing and why it is changing, why this is the best way to capture the aging process (which is the biggest risk factor for chronic disease and death) and what questions they are trying to answer. 09:59 Dr. Gladden asks if they are hitting a plateau in cost-effectiveness. 10:49 Dr. Gladden tells the audience why they should care about this and what sets TruDiagnostic apart from other methylation companies. They can predict disease and mortality. 13:44 Ryan talks about the evolution of these algorithms and what people can expect from the reports of their testing. 14:40 Second and third generation clocks are introduced during this intervention before tackling their reports individually. 17:15 Dr. Gladden talks about the benefits gained from these reports/testing. 18:55 What can people do to impact their methylation? Ryan elaborates on the different types of interventions, from lifestyle changes to clinical interventions. 23:19 Dr. Gladden introduces very small embryonic-like stem cells and talks about how there's data being recorded in some trials where these are moving the epigenetic age even 3 or 4 years back in time. 25:30 Ryan talks about what he's seeing with plasma and plasmapheresis interventions. Explains why the results they're seeing are giving them so much hope that these therapies might be one of the ways to reverse the clock. 29:30 Dr. Gladden explains why they can’t look at one data point and say that's the answer in this field. 29:58 They introduce the DunedinPace algorithm for rate of aging, which is the first ever third generation algorithm. Ryan explains why it's one of their favorites and how it is making things clearer and giving one of the best metrics they can offer. 35:00 Dr. Gladden talks about what they don't have dialed in yet with these therapies. 35:19 Ryan describes how they're trying to bridge the gap by providing answers to those "how long" questions with their data sets. 36:20 Will the system spring back to its natural age? Or will we be able to reset it? Dr. Gladden poses the question based on the concept of transient epigenetic aging. 36:58 Ryan talks about what he thinks is probably the most exciting area of age reversal right now. 38:49 Dr. Gladden asks Ryan how people can reasonably compare between companies doing this kind of testing and choose their best option. 40:40 Ryan explains the different tissues that can be used for testing and how that's going to affect the algorithm's results. 41:55 Ryan explains the importance of these algorithms' (clocks') precision. 43:20 Dr. Gladden talks about his experience with methylation ages in urine and how he uses it as a screening test. 44:53 Dr. Gladden introduces the GrimAge algorithm, which predicts when someone is going to die.  45:49 Ryan elaborates on the GrimAge algorithm's excellence and explains how it is the most accurate and most predictive.  49:43 Dr. Gladden explains what methylation measurements are actually doing and what they mean for the audience. 51:16 Dr. Gladden asks Ryan his top 3 pieces of advice to optimize your longevity, health and human performance.    Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast   https://twitter.com/TruDiagnostic  https://www.instagram.com/trudiagnosticofficial/  https://www.youtube.com/channel/UC408EGTLhAf8haqe1H5Ep_Q https://www.facebook.com/TruDiagnostic/ https://www.linkedin.com/company/trudiagnostic/

Join Dr. Gladden and Tina Anderson on this conversation about spore-based probiotics and their ability to rehab your overall health by targeting the bacteria in your gut. Tina Anderson, formerly a lawyer, used to work in the pharmaceutical industry before finding out that it wasn't the best way for her to help people and change their lives. After a harsh revelation during the peak of their careers, Tina and her husband pivoted to the world of natural and progressive health, and disease prevention. As a result of their discovery, they created a unique supplement with superior probiotic strains, giving birth to Just Thrive. These spore-based practitioner grade probiotics are the product that Tina and her husband created to help you take control of your health and change your life.    01:10 Dr. Gladden tells us what's exciting about this episode and the things we will come to understand.    02:10 Dr. Gladden introduces Tina Anderson.    03:20 Tina shares her story: the journey to the world of probiotics.    04:15 We get an insight into the abuses in the pharmaceutical industry.    04:53 Tina tells us the Sales Representative anecdote that really made them pivot from the pharmaceutical industry in the midst of a high point in her and her husband's careers.    06:47 We learn about the day the opportunity to create Just Thrive presented itself for Tina and her husband.    08:16 Tina lets us in on her biggest motivation.    08:45 Tina explains why her husband was seeing a naturopath at that time. Was someone in the family experiencing gut issues?    09:59 We are introduced to spore-based probiotics and what's special about them.    10:48 Tina explains what is the biggest difference between spore-based probiotics and regular probiotics.    10:58 Dr. Gladden explains that dead bacteria can also have an effect on our guts but live bacteria could, theoretically, be better.    11:25 Tina elaborates on what spore probiotics do that other probiotics can't do.    12:08 Tina talks about a gut model study where they confirmed a 30% favorable shift in the microbiome after 2 weeks on it.    13:04 Dr. Gladden explains that there is no "normal" gut biome.    14:08 We find out how exactly are these spores modulating the gut biome.    14:25 Tina makes a very good analogy where our gut is a garden and sporebiotics are the gardener and not just new seeds, as a way to differentiate them and their effects from those of regular probiotics. Are new seeds enough? Or do we need a gardener?    15:15 Tina also clarifies a big distinction in the colonization period of spore-based probiotics vs non-spore probiotics.    15:41 Dr. Gladden explains the concept of spores and asks how they work in this context.    16:57 Tina talks about a study where they measured the spores antibiotic survival capabilities.    17:16 Dr. Gladden elaborates on how antibiotics alter the gut biome.    17:54 Tina explains that spore probiotics can rehab AND maintain our health.    19:05 Dr. Gladden asks if sporebiotics can repair leaky-gut. Tina goes on to describe just how impressive is the level of restoration spores can achieve, proved by a double-blinded study that was performed.    21:31 Tina gives a better understanding of how exponentially detrimental leaky-gut can be to our health with a helpful leaky faucet comparison.    22:03 Dr. Gladden explains that the body is not built to be fragile but it has a threshold, resulting in people living with issues they don't know they have which are driving their inflammation levels up and accelerating aging.    22:30 Tina lists a number of issues and disorders that are stemming from the gut, although we don’t associate them with it.    24:05 Tina describes the spore-based probiotics success with bloating issues, diarrhea, and constipation.    24:40 Tina explains that our gut is foundational for our health and how it is the starting point of general wellness.    25:26 Dr.Gladden asks about using spore-based probiotics with antibiotics to decrease the negative effects of the latter, like induced diarrhea. Tina talks about a study that proved the spores effectiveness with this, and survivability to the strongest antibiotics.    26:31 How is it helping people's brain function?    27:00 Tina lists all the brain hormones that are produced in our gut.    27:17 Tina introduces the psychobiotic!    28:02 Tina tells us about other offenders of brain health that the psychobiotic is also helping with.    28:44 Dr. Gladden introduces the topic of probiotic cocktails.    29:17  Tina explains why a cocktail makes much more sense than just taking one probiotic.    30:27 Dr. Gladden inquires about what's on the drawing board for Just Thrive.    31:35 Tina explains that they're only focused on bringing what's truly missing in the market and how they want to make an impact by providing what's needed and what's best.    32:18 Dr. Gladden asks what kind of conditions/disorders they're targeting with the psychobiotic.    32:47 Tina explains how the psychobiotic targets not only certain disorders but specifically works to improve cognitive function too.    33:09 How quickly does this psychobiotic work?    34:04 Tina gives her recommendations for us to take action in favor of our longevity.    34:49 Dr. G explains how fasting acts as a workout for our gut biome.    35:09 Tina tells us the number of hours it would be beneficial to fast for and how to get there.    36:10 Tina shares which probiotics she takes right now.    36:44 Dr. Gladden talks about how he tries not to buy the same thing twice when he's doing his grocery shopping, and Tina explains how having a diverse microbiome is the key to being healthy.    39:04 Tina explains what is the key difference between their spore-based probiotics and all the other probiotics that are now coming into the market.    40:03 Dr. Gladden and Tina tell us how we can get a hold of the direct to consumer bio equivalent version of practitioner grade spore-based probiotics through Just Thrive.    41:13 Tina gives out the Just Thrive's website address: (justthrivehealth.com) to get these sporebiotics with a 20% discount.    41:55 Dr. Gladden and Tina Anderson say goodbye.    Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well.  Follow us on social media!  Instagram: @gladdenlongevitypodcast  Twitter: @GLPodcast_  Facebook: @GladdenLongevityPodcast  To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today!     Learn more about the better approach to gut health & wellness on their website: justthrivehealth.com     Or call the number: 1-800-455-8939  Email them at: info@justthrivehealth.com    Look them up on social media:  Instagram: justthrivehealth  Facebook: justthrive  Discount code: gladden15    

Join Dr. Jeffrey Gladden in this conversation with Colleen Cutcliffe, Co-Founder and CEO of Pendulum Therapeutics. Colleen earned a PhD in Biochemistry and Microbiology from Johns Hopkins University, did her postdoctoral work at Northwestern University, and is on a mission to make millions healthier through microbiome-targeted medical probiotics. In this episode, they discuss her personal journey to the creation and development of Pendulum, how it works to treat conditions like metabolic syndrome, inflammation and neurodegeneration, and the ways in which treating and maintaining a healthy microbiome could be a hack to successful aging and disease-free longevity. If you are looking for a natural route to overall health and optimization, this episode is for you.   Show notes: Dr. Gladden introduces Colleen, and she introduces herself, gives us her personal journey to the creation and development of Pendulum, her personal connection to it. (1:30)    Colleen talks creating products that have the efficacy of a drug but the safety of a probiotic. (2:40)    Colleen mentions a study that showed how kids taking antibiotics before six months of age are systematically more prone to diseases like obesity and type two diabetes as they age. Dr. Gladden mentions how antibiotics affect children. (4:00)    Colleen tells us how butyrate is a small molecule with a really important role in a variety of different things. Our colon cells, for example, are the only cells in our entire body that use butyrate as their source of energy, as opposed to glucose. (6:10)    Dr. Gladden explains how the fiber metabolism generates butyrate that feeds the intestinal lining, including how fascinating it is that this butyrate is responsible for releasing GLP-1. (7:30)    Colleen clarifies that if you are missing your microbes, ingesting fiber does not make much difference. (10:00)    Dr. Gladden mentions some misconceptions about microbiomes and comparing the person's stool against an "ideal" stool. (11:59)    Dr. Gladden talks about keystone strains and explains that what we are eating affects and influences them, highlighting the importance of eating different kinds of fibers. (14:00)    Colleen describes a study they did, seeing a way to influence the microbiome and then have this impact on A1C and blood glucose. (17:00)    Dr. Gladden talks about how microbes also affect appetites and dictate your cravings. (19:00)    Colleen explains that the (Pendulum) formulation is stable but needs to be refrigerated, and lists the five strains: Akkermansia muciniphila, Anaerobutyricum hallii, Bifidobacterium infantis, Clostridium butyricum, and Clostridium beijerinckii. (21:10)    Colleen mentions some of the trials they have done and the approach they adopted. (24:10)    Dr. Gladden brings up neuroinflammation and poses the question of Pendulum's capacity in decreasing it. (27:04)    Colleen elaborates on the known relationship between managing your blood glucose spikes and neural inflammation. (28:05)    Dr. Gladden explains what resting metabolic rate is and how it is measured. (32:44)    Colleen talks about the importance and role of diversity in your diet to metabolize some foods, maintaining "the fence to your garden" (gut lining of your microbiome) and the regulation of mucin, which is the glue that keeps everything properly in place. (35:34)    Colleen talks about what is on the drawing board for her at the moment. (39:15)    Dr. Gladden brings up the connection between autism and microbiomes. (41:30)    Colleen talks about considering microbiomes as an additional intervention effort. (43:25)    Colleen gives out her three takeaways for listeners: the diversification of our microbiome, the importance of regulating how your body metabolizes sugar, and giving yourself a boost with the Pendulum glucose control strains paired with the proper diet. (45:39)    Colleen emphasizes the importance of people consulting their physicians when making changes that could affect their health. (48:00)     Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well.  Follow us on social media!  Instagram: @gladdenlongevitypodcast  Twitter: @GLPodcast_  Facebook: @GladdenLongevityPodcast  To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today!        Website: Learn more about the next generation of gut health by visiting www.pendulumlife.com   Instagram: @pendulumlifeco  TikTok: pendulumlife  Facebook: https://www.facebook.com/PendulumLife/  (For Gladden Longevity listeners, use code GL20 to subscribe and save 20% on your first month of Pendulum's subscription products.)  

In this episode, Dr. Jeffery Gladden discusses with Dian Ginsberg MD, who has years of experience providing comprehensive obstetrics and gynecology treatment and is a functional medicine physician. They talk about young plasma, young plasma transfusion, and the various benefits. Dr. Ginsberg has a special interest in functional medicine and how it helps minimize severe symptoms and optimize health. She is the author of The PCOS Environmental Roadmap. Rectangularization of aging is her passion. She is faculty at the American Academy of Anti-Aging, where she lectured about bio-identical hormone replacement and telomeres (DNA caps) and how instrumental their preservation is for ongoing health. Dr. Gladden introduces Dr. Ginsberg and gives an overview of their discussions (1:00) Dr. Ginsberg introduces herself and how she got to start doing what she does today. She mentions how her transition to the functional space came from her kids and how she brought it into her Obgyn to help others. (2:59) Dr. Ginsberg mentioned how about three to four years ago, her patient decided to be involved in the longevity space and look at what younger factors could to the aging process. This led to them getting involved with a lab that collected plasma with young factors. (4:55) Dr. Ginsberg talks about how the lab they connected with was already using young plasma to randomly do a whole bunch of things. Dr. Gladden also mentions how sex/gender and blood groups are essential when using plasma. (6:35) Dr. Ginsberg mentions how plasma is used and what quantity is run into the recipient. She talks about how they started with a liter of plasma. Dr. Ginsberg also says running it very slowly helps them avoid problems and complications. The liter of plasma, as she mentioned, is usually infused in two to three hours, giving the body time to process it. (8:00) Dr. Ginsberg mentions that she is into the research aspects of plasma transfusion. She notes that as the research started to come out, people are becoming more receptive to using plasma transfusion. (10:32) Dr. Gladden mentions a study on Parkinson's done at Stanford, and Dr. Ginsberg responds that plasma is safe for people. (13:54) Dr. Gladden explains what Parkinson's disease is all about and mentions how it affects the brain and has systemic components. Dr. Ginsberg also notes how the improvement and benefits of plasma transfusion are measured. (16:12) Dr. Gladden speaks about his approach at Gladden Longevity and how albums are used. He also talks about removing the old stuff and putting in the young stuff. ( 19:30) Dr. Ginsberg talks about her present focus with respect to young plasma and mentions that we don’t know the answers to what is best. (21:00) Dr. Ginsberg mentions the arrays of tests and perspectives that she considers to give her an accurate picture of what is best. (22:50) Dr. Gladden mentions that there is a stress to undergoing the procedure and mentions some of the things they follow with people they work with. (25:35) Dr. Ginsberg talks about the safety of the plasma transfusion process, the basic screening, and other tests are done. (26:49) Dr. Ginsberg talks about the immune system and how powerful it is, HLA typing, and how the body reacts to a foreign substance. (28:00) Dr. Ginsberg talks about some of the studies they are involved in and what they focus on with respect to plasma transfusion. (32:00) Dr. Ginsberg mentions that eating right and exercising are great, but it’s important to put young factors back in. (36:10) Dr. Ginsberg mentions how the body has a cost of doing business and how cleaning the old stuff out and putting in something new is essential. Dr. Gladden also mentions how aging drivers are compounding on themselves. (38:35) Dr. Ginberg mentions one of the reasons why she finds plasma transfusion interesting and that it is a perfect mixture. (40:05) Dr. Gladden talks about oxytocin and how isolation affects older people. (42:18) Dr.Ginsberg mentions that they have two sites where people are being enrolled. (44:08) Dr. Ginsberg mentions her three takeaways for listeners. The first is to do what you can control and do what you can and maintain it every day. Number two is to get good testing as you grow older and do your bio-individual testing. Level three is to listen to expert advice religiously. (44:54) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today! www.dianginsbergmd.com www.youngplasmastudy.com

Dr. Jeffery Gladden chats with Dr. Gil Blander, internationally recognized for his research in the basic biology of aging and for translating his discoveries into new ways of detecting and preventing age-related conditions. He received a Ph.D. in biology from the Weizmann Institute of Science and completed his postdoctoral fellowship at MIT. He has been featured in CNN Money, The New York Times, Forbes, The Financial Times, and The Boston Globe. He is also the founder of InsideTracker. In this episode, Dr. Gladden and Dr. Gil discuss how Dr. Gil's passion and expertise in longevity informed his decision to found InsideTracker. Drawing from his expertise Dr. Gill also touches on how blood work is an ideal foundation for creating personalized lifestyle protocols intended to optimize longevity and how "set variables" like DNA, gender, and ethnicity play into a personalized quest for longevity. If you want to know how much a person can really impact longevity markers with non-medical, nutrition, and lifestyle interventions, then this episode is for you. Dr. Gladden welcome Dr. Blander. (1:20) Dr. Blander shares his personal journey and how he got to start InsideTracker, and his background. (1:50) Dr. Blander shares some insight into research that is ongoing on cellular senescence. Dr. Blander mentions his involvement in researching sirtuins, a gene found in yeast that can extend lifespan and cellular senescence, and the use of animal models in the research. (3:48) Dr. Gladden mentions that sirtuins are a family of proteins essential for longevity, and we go to great lengths to try to activate sirtuins by various mechanisms. (8:05) Dr. Gladden states how NAD/NADH ratio goes down with aging for various reasons. (10:41) Dr. Blander mentions how he came to America, became an entrepreneur, developed a model for caloric restriction, and talked about processes that change with caloric restriction. (12:39) Dr. Blander explained how he compared the signature of caloric restriction to mice treated with Resveratrol. (17:11) Dr. Blander talks about how using a cocktail of supplements could mimic calorific restriction. (18:40) Dr. Blander talks about the idea of optimizing our body, seeing what is happening inside our body, and fixing it using food. (20:11)  Dr. Bland talks about they are looking at blood biomarkers related to lipids, glucose metabolism, iron metabolism, and inflammation. He also spoke about how they are focused on biomarkers related to longevity instead of sickness. (22:00) Dr. Blander mentions the optimal level of glucose which is between 65 - 99, whether you are young or old. (25:34) Dr. Blander talks about the optimal glucose level for longevity and how it changes. (27:17) Dr. Blander talks about how fasting glucose changes and is affected by stress, BMI, sleep, and exercise. (29:17) Dr. Blander talks about inner and chronological age and how they are calculated. (35:16) Dr. Blander talks about his approach that identifies the problem, why the problem happened, and the solution. (37:17) Dr. Gladden talks about how intervention with food will affect more metrics that are being measured. (40:05) Dr. Blander explains how InsideTraker fits into our daily strategy regarding health and longevity. (42:27) Dr. Blander talks about changing your lifestyle in order to optimize yourself. (44:30) Dr. Blander details how the program works and how you can select the goal you are after. (45:09) Dr. Blander mentions that one of the essential things for longevity is building muscle and lifting weights, nutrition and sleep. (46:49)     Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today! LEARN MORE: www.InsideTracker.com sales@insidetracker.com (800) 513-2359 https://www.instagram.com/insidetracker https://twitter.com/InsideTracker https://twitter.com/gblander1 Discount code set: GLADDEN20, for 20% off everything but gift cards, valid thru 12/31/22

Dr. Jeffery Gladden sits with Ari Tulla, a San Francisco-based entrepreneur and the co-founder & CEO of the smart nutrition service, Elo, whose mission is to transform food from the leading cause of disease to medicine. Ari is also an active investor who is involved with many start-ups. In their discussion, they touch on healthcare, supplements, human performance and longevity. As the conversation progresses, they talk about how most of the US healthcare spending (over 50%) goes into managing diet-related chronic conditions while only 3% is spent on preventive care. They also touch on how long it takes for chronic conditions to develop and how long it takes to reverse them. In this episode, you also know how food is the preventive medicine we have today and the smart nutrition option Elo offers. This episode contains many practical and actionable takeaways you must not miss. Dr. Gladden welcome Ari to the show. (1:38) Ari talks about his fitness journey. (2:42) Dr. Gladden mentions how we need to be adaptable regarding exercising, our fitness routine, and making fitness and exercising habitual. (4:54) Ari says it’s essential to create time for yourself and for what is most important to you by blocking out the time. ( 7:18) Ari gives details about his fitness and nutritional journey. (9:18) Dr. Gladden buttresses Ari’s point about how food quenches or fans the flames of inflammation. (13:41) Dr. Gladden mentions how decluttering your life and diet leads to lower stress levels. (16:41) Ari goes over the mission statement of Elo, which primarily is to make food medicine. He also opens up on the idea of smart nutrition, how it’s personalized, made for you, precise and proactive. (20:11) Ari explains the concept of gamifying the monitoring of health indicators and real-time feedback. (25:30) Ari suggests doing small things or making small changes that make a big difference. (29:45) Ari states how he is approaching the challenge of creating a massive impact through Elo and things they are looking out to implement. ( 37:00) Dr. Gladden explains the importance of nutrient density and taking nutrient-dense food and how taking nutrient-dense food takes your hunger away. (44:40) Ari speaks about how controlling your food can significantly impact your weight. (46:10) Dr. Gladden emphasizes how eating nutrient-dense food will make people less hungry and get the nutrients they want. (48:30) Dr. Gladden speaks about the declining life span and declining health span. (54:33) Ari mentions the top 3 things to extend longevity, and he touches on food, sleep, and movement. (55:25)   Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today! LEARN MORE ABOUT ELO: Signup Elo at https://www.elo.health/ Follow Elo on Instagram, Facebook, and Linkedin Download Elo iOS app at https://apps.apple.com/us/app/elo-health/id1537708963 Elo Free Biomarker test Feel free to share the Elo free biomarker test and nutrition consult offer to your network. How does it work? Go to  https://www.elo.health/ and signup with code GLADDENLONGEVITY to start the Elo program with a free biomarker test and nutrition consult. What’s included in the Elo biomarker test: https://www.elo.health/articles/how-to-collect-a-successful-blood-biomarker-sample-at-home/   What’s included in the Elo $99/m program? 🩸Biomarker testing every 90 days 💊 Personalized supplements monthly 🥬 Quarterly nutrition evaluation 📈 Ongoing monitoring and support 👧 1:1 health coaching every 90 days

Dr. Jeffery Gladden sits with Amy Albright and Drew Pierson. Drew is an expert in neural feedback, doing EEGs, and also designs programs to help reset the brain. They all talk about neural feedback and do a little bit of spiritual diving. They talk about the inner cycle of life's energy force and its foundation for health, longevity, and performance. The talk about the major components of the inner cycle of life energy forces like growth mindset, optimizing mental health, feeling loved, letting love flow, optimizing relational health, feeling joy, optimizing spiritual health, optimizing wisdom, feeling safe, and feeling energetic resonance with the universe or a greater sense of purpose. Dr. Gladden talks about meeting Amy and Drew on a weekend retreat in California and talked about the inner cycle of life's energy force. (1:16) Dr. Gladden welcomes Amy and Drew to the show, and Amy and Drew talk about the approach to optimizing life, health, optimizing life energy, and longevity. (4:07) Amy talks about having a life’s purpose and what it means to different people, and Drew talks about how what he does is complementary to what  Amy does. (7:16) Dr. Gladden talks about his experience working with Amy and Drew and how it works in rewriting the brain's software. (10:00) Amy talks about how she works with Drew to help clients optimize and help with current problems, future problems, and being their best selves. (13:10) Amy talks about how safety is an underrepresented topic and its importance for everything. (17:00) Drew mentions how their training helps clients gain control over their subtle actions. (21:05) Amy lets us know that what people ascribe as personality is a collection of fears and a lack of safety kind of instances. (23:00) Dr. Gladden mentions that we are the agents of our disease and the agent of our health. (26:01) Drew says that the growth and learning have kept him interested in the field. (30:30) Amy mentions that it is not about if we have arrived as we move forward but that there is more. (35:11) Amy mentions that when people go towards the things they are afraid of, they are actually establishing a bigger foundation of safety. (40:20) Dr. Gladden mentions that if people could communicate telepathically, there would be better communication and collaboration. (45:15) Amy refers to how friends, twins, people who spend more time together, and married couples start to know things about each other. (50:12) Amy uses an analogy to explain consciousness. (55:25) Drew talks about how breathwork is a key to so many things and how it shifts consciousness. (59:23) Amy gives some take-aways, which include finding and staying in that state of passion and “fully aliveness,” striving to be in command of your reality, remembering that science may not be enough to find all the meanings and looking at science plus spirituality for answers. (1:01:34) Amy talks about the Awaken Intensive. (1:05:39) If you would like to learn more about Holon and the Awaken Intensive, visit https://www.holonexperience.com/ If you would like to learn more about coaching and advising, visit www.DrAmyAlbright.com  If you would like to learn more about the 3-month neurofeedback training programs, visit www.DrDrewPierson.com   Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today!