OncoPharm

John Bossaer
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Jan 19, 2023 • 13min

Adjuvant Interferon In Melanoma

The Landmarks in OncoPharm series returns to discuss adjuvant interferon in melanoma. ECOG 1684: https://pubmed.ncbi.nlm.nih.gov/?term=36649675 Commentary on E1684: https://ascopubs.org/doi/abs/10.1200/JCO.22.02354
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Jan 12, 2023 • 20min

Breast Cancer In A Nutshell

Broad, big picture overview of breast cancer and its treatment. Ambitious. Do not recommend listening at 1.5x
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Jan 5, 2023 • 21min

Mosunetuzumab And Same-day Pegfilgrastim w/ ddAC

New Year - New Drug, mosunetuzumab (a CD3-CD20 T-cell engager) is approved for r/r Follicular Lymphoma. And an intriguing retrospective cohort study found a higher rate of neutropenia with same-day pegfilgrastim in patients receiving dose-dense AC. Link: https://doi.org/10.1177/10781552221148116
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Dec 29, 2022 • 20min

2022 New Drug Review

This gift-giving season, we ask whether we want to Keep, Re-gift, or Return new oncology drugs approved this past year.
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Dec 22, 2022 • 17min

Project Renewal: Capecitabine

The FDA's pilot program, project renewal, uses capecitabine for its first label makeover. What's new & what are the possible implications of the DPYD warning now in the prescribing information?
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Dec 16, 2022 • 15min

ASH 2022 Highlights

Thought on: Double Dauno, but they said it better --> (https://open.spotify.com/episode/0eHEl3bUdZdg3mynUiNMG6?si=88cdab4b882e4667) Blinatumumab FTW The end of "the" neutropenic diet?
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Dec 8, 2022 • 18min

TILs, Olutasidenib, T-DXd

Tumor-Infiltrating Lymphocytes (TILs) getting closer to entering practice. Updated survival results published from DESTINY-Breast03 (T-DXd vs. T-DM1). A new IDH1 inhibitor, olutasidenib, is FDA-approved for relapsed or refractory AML.
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Dec 1, 2022 • 14min

Bad News For Belantamab-Mafodotin And Atezolizumab's Bladder Cancer Indication

Recent voluntary withdrawals from the US market of belantamab-mafodotin and atezolizumab's indication for bladder cancer have us weighing (again) the pros & cons of the accelerated approval program. Also, FDA approves the 1st fecal transplant product.
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Nov 17, 2022 • 19min

Mirvetuximab Soravtansine

A new antibody-drug conjugate is approved for ovarian cancer.
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Nov 10, 2022 • 14min

Metastatic NSCLC Updates: Role of CTLA-4 inhibitors?

We review the 5-year update of CheckMate 227 and the POSEIDON to generate the hypothesis that CLTA-4 inhibition has a role in PD-L1 negative metastatic NSCLC. CM 227 update: https://pubmed.ncbi.nlm.nih.gov/?term=36223558 POSEIDON: https://pubmed.ncbi.nlm.nih.gov/?term=36327426 Editorial: https://pubmed.ncbi.nlm.nih.gov/?term=36331243

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