OncoPharm Breast Cancer In A Nutshell
Jan 12, 2023
Explore the intricate world of breast cancer with insights on incidence, mortality, and defining risk factors like genetics and estrogen exposure. Discover the various subtypes of breast cancer, including luminal and triple-negative, and the significance of screening. Learn about surgical options, the timing of chemotherapy, and who needs it. Delve into hormonal therapies, the chronic nature of hormone-positive disease, and recent advances like CDK4/6 inhibitors and immunotherapy. A comprehensive overview packed with essential information!
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Why This 'Nutshell' Episode Exists
- John Bazar created a prior 'Sarcoma in a Nutshell' episode and used listener metrics to decide to make this breast cancer overview.
- He intends this episode for learners who often miss the 'forest for the trees' in oncology education.
Breast Cancer Is Highly Prevalent Yet Often Chronic
- Breast cancer is the most commonly diagnosed cancer yearly, with ~287,000 cases and ~40,000 deaths in the U.S. each year.
- Nearly 90% of diagnosed women survive five years, making breast cancer a highly prevalent chronic disease among survivors.
Three Broad Risk Factor Categories
- Major breast cancer risk factors fit three buckets: genetics, lifetime estrogen exposure, and environmental factors.
- Examples include BRCA mutations, early menarche/late menopause, nulliparity, and obesity raising postmenopausal risk via adipose estrogen production.