OncoPharm

Ide-Cel vs. "standard" treatment in relapsed/refreactory multiple myeloma study - the KarMMa-3 trial - is discussed. Link: https://www.nejm.org/doi/full/10.1056/NEJMoa2213614

CodeBreak200: docetaxel vs. sotorasib in 2nd-line metastatic NSCLC (KRAS-G12C). A new safety signal emerges. https://doi.org/10.1016/S0140-6736(23)00221-0 A new survival prediction model for elderly patients with AML not receiving intensive therapy. https://doi.org/10.1002/cncr.34609

Recent FDA approval of adjuvant pembrolizumab for NSCLC brings hope, particularly after platinum chemotherapy. The comparison with atezolizumab reveals intriguing differences in patient outcomes. Excitingly, elacestrant emerges as a breakthrough treatment for ESR1-mutant breast cancer, heralding a new era of targeted therapies. Pirtobrutinib offers promise for those facing resistance in mantle cell lymphoma. Dive into the evolving landscape of oncology with insights on treatment sequencing and the challenges of resistance.

Tucatinib's FDA-approval (with trastuzumab) for HER2 amplified metastatic colorectal cancer launches a new era of targeted therapy in colorectal cancer. Targeting HER2 (amplified in ~3-5% of advanced colorectal cancers) in colorectal cancer will likely evolve over the coming years, so a brief history on how it has evolved so far may be helpful.

The Landmarks in OncoPharm series returns to discuss adjuvant interferon in melanoma. ECOG 1684: https://pubmed.ncbi.nlm.nih.gov/?term=36649675 Commentary on E1684: https://ascopubs.org/doi/abs/10.1200/JCO.22.02354

Explore the intricate world of breast cancer with insights on incidence, mortality, and defining risk factors like genetics and estrogen exposure. Discover the various subtypes of breast cancer, including luminal and triple-negative, and the significance of screening. Learn about surgical options, the timing of chemotherapy, and who needs it. Delve into hormonal therapies, the chronic nature of hormone-positive disease, and recent advances like CDK4/6 inhibitors and immunotherapy. A comprehensive overview packed with essential information!

New Year - New Drug, mosunetuzumab (a CD3-CD20 T-cell engager) is approved for r/r Follicular Lymphoma. And an intriguing retrospective cohort study found a higher rate of neutropenia with same-day pegfilgrastim in patients receiving dose-dense AC. Link: https://doi.org/10.1177/10781552221148116

This gift-giving season, we ask whether we want to Keep, Re-gift, or Return new oncology drugs approved this past year.

The FDA's pilot program, project renewal, uses capecitabine for its first label makeover. What's new & what are the possible implications of the DPYD warning now in the prescribing information?

Thought on: Double Dauno, but they said it better --> (https://open.spotify.com/episode/0eHEl3bUdZdg3mynUiNMG6?si=88cdab4b882e4667) Blinatumumab FTW The end of "the" neutropenic diet?