Big Picture Medicine

0:00 Intro 1:04 The genius business model of GetHarley 5:26 How important is marketing? 50% of revenue 14:57 Why aren't they doing cooler more innovative stuff? 22:38 What verticals would we expand GetHarley's biz model to 24:37 Vitamin vs painkiller 27:49 Why have investors put so much money into GetHarley? 31:00 Feedback and outro Links mentioned GetHarley, a skincare telehealth and consultation platform, raises $52M (TechCrunch): https://techcrunch.com/2023/06/06/get... Podcast Links YouTube:    / @bigpicturemedicine   Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

0:00 Intro 0:20 DEA comes after DTC health startups 3:18 How DTC health startups hacked customer retention 10:30 Will this kill the economics of D2C health startups? 12:57 How would we solve the problem 15:30 New LLM Paper in Nature 28:18 Audience feedback and outro Links Mentioned Cerebral Pushed ADHD Prescriptions And Failed To Report Data Breaches, Ex-Executive Alleges In Lawsuit (Forbes): https://www.forbes.com/sites/katiejennings/2022/04/28/cerebral-pushed-adhd-prescriptions-failed-to-report-data-breaches-ex-executive-alleges-in-lawsuit/DEA's proposed telehealth rules pull back COVID-era remote prescribing flexibilities: https://www.fiercehealthcare.com/telehealth/deas-proposed-telehealth-rules-tighten-covid-era-remote-prescribing-regulations DEA extends telehealth prescribing flexibilities for 6 months: https://www.fiercehealthcare.com/health-tech/telehealth-providers-cheer-dea-moves-temporarily-extend-virtual-prescribing Health system-scale language models are all-purpose prediction engines (Nature): https://www.nature.com/articles/s41586-023-06160-y Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

Sokratis Papafloratos, the founder and CEO of Numan, a booming men's digital health startup, shares his vibrant journey in the health tech arena. He discusses the key to their $70M funding and what separates successful entrepreneurs from the rest. Papafloratos also emphasizes innovative marketing strategies, including the balance of kindness and assertiveness in leadership. With insights from his past experiences, he candidly reflects on entrepreneurship's ego and narrative power, while critiquing the missteps of others like Adam Neumann.

0:00 Intro 0:18 Ali Parsa's Immigrant Story 1:57 Picking a Problem That Was Too Big 4:15 The Supply Induced Demand Problem 5:55 The Unit Economics Problem 7:37 The Misaligned Incentives Problem 10:11 The Friction Problem 12:06 The First Mover Disadvantage 13:30 Raising Too Much Money 14:55 The SPAC Problem 17:40 The Pig With Lipstick Problem 22:07 Should Founders be Liberal with the Truth? 26:06 What Will the Next Health Unicorn Be? Articles Mentioned Babylon shareholders wiped out in restructuring deal: https://www.ft.com/content/ce42bcb7-d9ee-4667-910a-b6c7a419449b Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

0:00 Intro 0:38 VC Dirty Money (LP Sources) 8:30 Power Dynamics Founder vs VC 12:56 Trillion $ Alzheimer's Opportunity 14:26 Eli Lily's New Alzheimer's Blockbuster (?) Donanemab 19:01 More Issues with Donanemab Phase III Results 21:48 Will Anyone Pay for Donanemab? 24:13 Donanemab Side Effects 27:15 Startup Opportunities in Alzheimer's  31:34 Outro Articles Mentioned Founders need to take a stand against VC's 'dirty money’: https://sifted.eu/articles/founders-vc-dirty-money Eli Lily Donanemab Phase III Press Release: https://investor.lilly.com/news-releases/news-release-details/lillys-donanemab-significantly-slowed-cognitive-and-functional Cost Effectiveness of Donanemab: https://pubmed.ncbi.nlm.nih.gov/35344024/ Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat?s=20 Dr Mustafa Sultan: https://www.musty.io/

Papers Mentioned— ChatGPT better + more empathetic than human doctors (JAMA Int Med Paper): https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2804309 Detecting eye disease using AI (Nature Biomedical Engineering): https://www.nature.com/articles/s41551-022-00867-5 Predicting dementia using LLMs (PLOS Digital Health): https://pubmed.ncbi.nlm.nih.gov/36812634/ AI recognises race from black and white X rays (Lancet Digital Health): https://www.thelancet.com/journals/landig/article/PIIS2589-7500(22)00063-2/fulltext VC dirty money article: https://sifted.eu/articles/founders-vc-dirty-money 0:00 Intro 0:30 ChatGPT vs Doctors (JAMA Paper) 15:57 AI Better at Diagnosis than Doctors 30:57 Dirty VC Money 32:02 Audience Feedback Joined by: Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

0:00 Intro 0:32 Why are VCs so unhappy? 2:18 What’s hard about being a VC? 3:56 Hustle culture, FOMO, always-on culture in VC 9:54 Is it ever easy to become rich? 12:22 It’s time to build in healthcare 15:31 Why is healthcare so hard for big tech? 17:31 Reasons why healthcare is easier than you think 21:04 Imposter syndrome for tech people entering healthcare 24:03 Would you build another healthcare startup? 25:12 Outro Joined by: Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health.  Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Martin Shkreli is an American Investor, Pharmaceutical Executive and Hedge Fund Manager who became the most hated man in America in 2015 when he obtained the drug Daraprim and increased its price from $13.50 a pill, to $750 overnight. 0:00 Intro 1:56 The Big Short 8:04 How to price a drug 20:01 Should we price drugs like iPhones 25:36 Pharma's dirty secret with R&D spend 34:12 Why are we not discovering more drugs? Eroom's Law 43:59 Marting's new AI Doctor — Dr Gupta 51:08 What's the FDA going to say? 53:26 Problems with GPT-4; hallucinations and sources 1:00:00 Mental health impact of being the most hated man in America 1:02:30 How rich are you? 1:08:00 Outro Daraprim is used to treat or prevent parasitic diseases, commonly in patients with HIV or AIDS. He defended the move by saying “If there was a company that was selling an Aston Martin at the price of a bicycle, and we buy that company and we ask to charge Toyota prices, I don't think that that should be a crime.” Unrelated to the Daraprim scandal, in 2017 he was charged with securities fraud and sentenced to seven years in prison and fined a total of over $70M dollars. Martin comes from humble beginnings, his parents are Albanian immigrants — but he quickly ascended the world and became a multimillionaire polymath. And despite having no formal training in Medical Sciences — he has a penchant for consuming medical literature from PubMed, and making novel insights. We talk about how Martin does this, his philosophy around drug pricing — and whether we should think about pricing drugs in the same way we price iPhones, we talk about whether blowing more money into pharma research & development actually leads to more exciting drugs, Martin’s new AI doctor that he just launched and the mental health impact of being the world’s most hated man. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Ben Maruthappu is the the Co-founder and CEO of Cera Care; a digitally-enabled social care company which has raised over $400M dollars. He was made a Member of the Order of the British Empire in 2020. 0:00 Intro 0:47 Ben's story 6:10 How to have good ideas, at the right time 12:14 Good decisions Ben made with Cera to scale 21:07 Is the US greener pastures? 28:10 What healthtech can learn from fintech, ridesharing and food delivery 30:17 Anti-lessons from other industries 33:53 How do you stop driving becoming toxic 36:13 Are founders olympic athletes who don't deserve work-life balance? 38:31 Are you full of sh*t? What are your real motives? 41:19 Are successful founders happy people? 43:30 Mo money mo problems 46:51 The power of vulnerability vs the magnetism of certainty 52:21 Networking advice You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Ala Alenazi is a TechBio Investor at Ascension and holds a PhD in Molecular Genetics from Cambridge University — she describes herself as a recovering scientist with extreme FOMO. 0:00 Intro 0:47 Being bombastic 3:32 Do PhDs make good VC investors? 10:38 How much of VC is luck? 12:47 Network building in VC 19:16 Getting deal flow 22:15 How to ask for things 24:43 Experience being a brown woman in VC 28:42 No one gives you anything, you just have to take it 33:50 Main character syndrome We talk about how being bombastic is the key to getting opportunities, why contrary to popular belief — PhDs don’t suck as investors, how to ask people to do things for you and what it’s like being a brown woman in VC. You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io