Big Picture Medicine

Rewind.ai just raised their Series A at a valuation of $350M. Investors include Andreesen Horowitz, Reddit’s Alexis Ohanian and OpenAI’s Sam Altman. Rewind sits on your computer and phone, and watches everything you do. Then you can ask it questions like: What was that really great Mediterranean recipe I looked at last month? Or I’ve got a call with a client next week, can you summarise every interaction I’ve had with them? But here’s where it becomes even weirder, powerful. They’ve announced the Rewind Pendant, a small audio recorder that sits on your chest. Rewind will be able to listen in to every conversation you have. You can ask it: What birthday present should I get for my partner? Did they drop any hints? Or how many arguments did we have last year? Pretty Black Mirror, right? Once you get over the ick however, you realise that this is correcting a lagging human function. Just like the cursed amongst us wear glasses; tools like Rewind will repair our broken memories. I spoke to Dan Siroker, Rewind’s founder— 0:00 Intro 1:54 Lessons from the Obama Campaign 3:28 How to use science to make your startup succeed 8:21 Privacy concerns 17:00 Rewind.ai as a brain-computer interface (BCI) 20:27 Forgetting is important for human wellbeing 22:26 Societal impacts of perfect memory 28:42 Rewind's tech stack 31:56 The existential risk of startups using GPT 35:21 D2C is harder than B2B 37:49 Leadership lessons 40:31 Perils of being a second time founder 46:44 Is any publicity good publicity? Links Rewind: https://www.rewind.ai/ Dan Siroker: https://twitter.com/dsiroker Dr Mustafa Sultan: https://www.musty.io/

People are wearing Apple Watches to their wedding days. Has this whole 'quantified self' movement gone bananas? Is any of this data actually useful? I spoke to Maitham Dib about this. He's building Vital (YC21); a startup which makes all wearable/lab data available to other startups/companies. 0:00 Wearable data is mostly useless 3:22 The case for wearable data 6:37 Wearable data is mostly useless 8:06 Wearable data is useful 10:16 The big opportunity with wearable/lab data (startups) 14:15 Naivety as a superpower (Paul Graham) 15:45 Why building Vital is so hard 19:31 Pros/cons of an infrastructure play in healthcare 20:51 How to enterprise sales 24:09 Lessons from YCombinator 27:32 The benefits of being an immigrant Links Vital: https://tryvital.io/ Dr Mustafa Sultan: https://www.musty.io/

Dr Jared Dashevsky, Healthcare Huddle (acquired by Workweek), shares 12 frameworks for healthcare content creation. Topics discussed include the importance of consistency, unique/controversial takes, network building, injecting personality, the value of boring content, audience acquisition, lessons from Jerry Springer, and the danger of hyper-optimization in content creation.

Dr Imran Haque, SVP of AI and Digital Sciences at Recursion Pharmaceuticals, discusses why AI drug discovery is challenging, the need for better understanding of drug interactions, the trade-offs in translational models, advancements in computational modeling and data acquisition in biology, and the value of being a generalist in the field.

0:00 NVIDIA's $50M investment into Recursion Pharmaceuticals 2:28 NVIDIA is becoming a seed investor 3:45 Bull case for Recursion Pharmaceuticals 9:20 Recursion's two big acquisitions 13:05 How are Recursion going to make money? 14:15 Recursion is overhyped 19:45 Recursion is unprofitable 22:21 Kim Kardashian's full body MRI scan 26:03 Longevity doctor's advice to Kim K 31:49 Speculating on Kim K's longevity regime (what she takes) 35:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

Ever waited months for a scan? Scan.com is making getting a scan as easy as booking an Uber. Behind the scenes of the disruptor changing medical imaging forever. 0:00 Race to the bottom? 1:34 AirBnB 11 star framework 9:57 Scan.com looks really easy to build — what's hard about it? 12:19 Lessons from working at Deliveroo 15:14 How do you make a lot of money? 19:41 Buying the domain name Scan.com 24:16 How to build a marketplace business 27:50 The perils of price transparency 30:36 What I would do to build a competitor 32:43 You need grit when building a health startup 35:46 Billion $ health ideas Podcast Links YouTube: https://www.youtube.com/channel/UCEzluDRmBTVby0WsO37V-xg Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Mustafa Sultan: https://www.musty.io/ Charlie Bullock: https://scan.com/

0:00 David Sinclair's controversial claim 1:39 Bull v bear case 6:23 David Sinclair's history of exaggerating and profiteering 8:34 Adam Neuman's involvement 11:40 Raising from unsophisticated investors 16:30 Why aren't big pharma interested in longevity? 22:45 Cynics are right, optimists get rich 25:26 Will a longevity drug be the most valuable therapeutic ever made 28:52 Feedback and outro David Sinclair's Tweet: https://twitter.com/davidasinclair/status/1679178670743732249?s=20 David Sinclair's Research Paper: https://www.aging-us.com/article/204896/text Elon Musk Tweet: https://twitter.com/davidasinclair/status/1679504700285104129?s=20 Dr Charles Brenner's Critique of Sinclair: https://twitter.com/CharlesMBrenner/status/1679213673771057152?s=20 Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

0:00 Why not let the builders build? Move fast and break things? 1:56 Why don't you ban people from googling their symptoms? 3:28 Is a disclaimer enough? 5:27 Why are LLMs difficult to regulate? 10:13 Move fast and kill patients — principal agent problem 12:23 People aren't idiots (they are) 14:20 Dr ChatGPT will never work 17:35 Spotting bubbles in healthcare 19:20 How much time does regulation add onto medical device approval?21:40 Can we ever regulate LLMs? Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Hugh Harvey: https://www.hardianhealth.com/ Dr Mustafa Sultan: https://www.musty.io/

Daniel Ek (Spotify Founder) has raised $65M for his new longevity startup: Neko Health. 0:00 What is Neko Health 2:18 They're doing nothing new 5:33 The bull case; why it's going to be huge 7:47 How are they possibly going to make money!? 18:30 Why aren't they doing full body MRI? 20:26 The bear case; why this will fail 25:13 Smells a bit hypey 29:15 The risks of longevity startups and early testing 35:41 The lowdown 37:47 Unexpected way of making $$$ 40:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

0:00 Leaked secret Apple health report 5:06 What Apple are up to in healthcare 9:21 Decentralised clinical trials 11:35 Apple healthcare leaked documents controversy 15:38 Apple is going to become a health insurer 23:07 Imran's advice to Tim Cook 26:11 Being a healthcare provider is unprofitable 28:12 Apple will make a longevity/subscription health play 30:27 Outro and feedback Links mentioned Apple Struggles in Push to Make Healthcare Its Greatest Legacy (Wall Street Journal): https://www.wsj.com/articles/apple-struggles-in-push-to-make-healthcare-greatest-legacy-11623832200 Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/