
The Self-Brain Surgery™ Podcast with Dr. Lee Warren
Neurosurgeon and award-winning author Dr. W. Lee Warren, MD delivers weekly prescriptions from neuroscience, faith, and common sense on how to lead a healthier, better, happier life. You can’t change your life until you change your mind, and Dr. Warren will teach you the art of self-brain surgery™ to get it done. His latest book, Hope Is the First Dose, is available everywhere books are sold.
Latest episodes

Mar 10, 2025 • 1h 1min
Outside-In Thinking Will Change You From the Inside Out (S12E26)
In this powerful episode, Dr. Lee Warren discusses the concept of transforming your life by changing the way you think about yourself. He introduces two powerful tools: a new self-brain surgery operation called 'Outside In Thinking' and a 'premortem analysis'. Through the podcast, Dr. Warren teaches listeners how to manage trauma, performance issues, and improve overall capabilities by adopting a new perspective. He encourages practical steps such as journaling and self-reflection to eliminate limiting stories and build a stronger mindset. The episode also highlights the importance of embracing guidance from faith and science to achieve personal transformation.00:00 Introduction and Purpose02:00 Listener's Story: Finding Hope04:53 The Power of Sharing05:48 Personal Reflections on Loss09:54 Understanding Self Brain Surgery16:48 New Operation: Outside-In Thinking28:50 God's Perspective on You29:52 Building Yourself from the Inside Out30:50 The Reticular Activating System31:35 Outside-In Critical Thinking32:57 Premortem Analysis: A Powerful Tool37:36 Avoiding Common Pitfalls40:11 Biblical Insights on Planning Ahead41:46 Realistic Thinking and Self-Discipline53:13 Final Thoughts and EncouragementClick here for the transcript!Resources and Links
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Learn more about your ad choices. Visit megaphone.fm/adchoices

Mar 3, 2025 • 46min
Hope in the Gray Areas, with Jenn Kautsch (aka Sober Sis) (S12E25)
In this episode, Dr. Lee Warren introduces Jenn Kautsch, the founder of Sober Sis, a community aimed at helping women reevaluate their relationship with alcohol. With a mission to offer an alternative to the 'wine o'clock' culture, Jenn shares her personal journey of choosing an alcohol-free lifestyle and creating a support network for like-minded women. Jenn discusses the concept of 'gray area drinking,' emphasizing the importance of curiosity, compassion, and self-awareness. The episode delves into the science behind alcohol's impact on the brain, the role of faith in Jenn's journey, and practical tips for those considering a sober or mindful approach to drinking. Listeners also get insights into Jenn's book, Look Alive, Sis!, and how her experiences and community-driven approach offer hope and freedom from habits that hinder personal growth.Chapters:00:00 Introduction and Guest Announcement03:09 Jenn Kautsch's Journey to Sobriety06:40 The Concept of Gray Area Drinking11:47 Creating the Sober Sis Community27:34 The Science Behind Alcohol and Anxiety33:18 Jenn's Book and Final ThoughtsClick here for the transcript!Resources and Links
Jenn's website, Sobersis.com
Jenn's book, Look Alive, Sis!
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Learn more about your ad choices. Visit megaphone.fm/adchoices

Feb 24, 2025 • 1h 2min
The School of Self-Brain Surgery (S12E24)
In this episode, Dr. Lee Warren introduces the concept for The School of Self-Brain Surgery™, discussing its benefits and techniques. He shares personal anecdotes and listener stories to highlight how this method has changed lives. Dr. Warren outlines the forthcoming School of Self-Brain Surgery, detailing its structure, enrollment, and the blend of neuroscience and faith that underpins the method. He emphasizes the separation of mind and brain, debunks common lies we believe about ourselves, and explains the importance of becoming the 'surgeon' in managing our thoughts and emotions. The episode concludes with practical advice and motivational insights to help listeners start transforming their lives by changing their minds.Chaoters00:00 Welcome and Listener Stories00:55 Introducing the School of Self Brain Surgery02:15 The Importance of Changing Your Mind03:21 Engaging with the Podcast Community06:22 Overview of Self Brain Surgery School09:35 The Scrub Sink Ritual25:07 Mind vs. Brain: Understanding the Difference28:54 The Three Lies That Hold Us Back28:58 Lie #1: I Am Just My Brain29:09 Lie #2: My Brain Determines Everything30:21 Lie #3: I Am My Trauma31:04 Rejecting the Lies32:42 The Power of Self Brain Surgery33:12 Affirmations for Change34:57 Understanding How Brains Work43:02 Self Brain Surgery Explained47:41 Becoming Your Own Surgeon49:13 The Path to True Happiness54:59 Final Thoughts and EncouragementClick here for the transcript!Resources and Links
Sponsors-
TImeline: Visit timeline.com, and use the discount code leewarren for 10% off your first order of MitoPure!
Aquatru: Visit aquatru.com and use discount code DRLEEWARREN for 20% discount on any Aquatru water filtration system!
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Learn more about your ad choices. Visit megaphone.fm/adchoices

Feb 17, 2025 • 54min
Quantum Decision-Making (S12E23)
In this episode of the Self Brain Surgery Podcast, Dr. Lee Warren delves into the power of observable, yet often overlooked, aspects of our behavior and decision-making processes. Inspired by a quote from Sherlock Holmes, Dr. Warren discusses a new approach called 'quantum decision-making.' This method merges modern neuroscience with faith, offering tools to make better decisions, improve prayer, and foster better interactions. Dr. Warren emphasizes the distinct roles of the brain and mind, suggesting that significant changes can be made by altering our focus and thoughts. The episode challenges listeners to move beyond deterministic thinking and embraces the transformative power of conscious choice, supported by scientific principles and spiritual wisdom.Chapters00:00 Introduction to Self Brain Surgery Podcast00:28 The Power of Observation02:34 Challenging Hardwired Beliefs07:32 Quantum Decision-Making Explained08:07 Classical vs. Quantum Physics13:44 The Impact of Quantum Physics on Neuroscience15:29 The Power of Quantum Decision-Making26:46 The Power of Pausing and Reflecting27:08 Redefining Trauma and Response30:46 Quantum Decision-Making Explained32:32 The Neuroscience of Change34:57 Faith and Quantum Decision-Making40:21 Practical Applications of Quantum Prayer48:27 Challenge: Engage in Quantum Decision-Making49:02 Conclusion and Call to ActionClick here for the transcript!Resources and Links:
Our sponsor for this episode is TImeline: Visit timeline.com, and use the discount code leewarren for 10% off your first order of MitoPure!
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Learn more about your ad choices. Visit megaphone.fm/adchoices

Feb 10, 2025 • 59min
Exploring the Mind-Brain Connection (S12E22)
Discover the transformative power of self-brain surgery, where changing your thoughts can change your life. Delve into the crucial distinction between the mind and the brain, shedding light on common misconceptions that hold you back. Learn how to automate healthier reactions and develop new brain habits for improved well-being. Explore the intersection of science and spirituality, and become the architect of your own life, taking charge of your mental and emotional landscape to unlock your true potential.

Feb 3, 2025 • 57min
Never Too Old to Heal (S12E21)
In this episode, Dr. Lee Warren explores how to achieve abundant living and overcome obstacles such as feeling stuck, anxious, or lost. He introduces the concept of the Diderot Effect, which highlights how acquiring new possessions can lead to an endless cycle of wanting more. Dr. Warren shares a personal story about buying a tractor and needing multiple attachments, illustrating how this effect can manifest in daily life. He emphasizes that genuine change and happiness come from within and offers ten actionable rules for cultivating abundance in life. These rules include embracing healing, positive thinking, and finding light even in the darkest times. Special attention is given to the power of neuroplasticity, biblical principles, and practical tips for mental and spiritual transformation. The episode aims to guide listeners towards a more fulfilling and abundant life.Chapters00:00 Introduction and New Beginnings01:39 Understanding the Diderot Effect05:55 Recalibrating for a Better Year15:46 The Power of Healing and Change21:58 10 Rules for Abundant Living29:18 The Power of Neuroplasticity30:11 Embracing God's Promises31:05 Healing Beyond Physical Illness32:35 Overcoming Negativity37:16 Finding Hope in the Darkness39:42 Transforming Trauma44:43 Cultivating Happiness46:36 Taking Action Against Overwhelm47:44 Spiritual Cleansing and Renewal50:08 The Journey of Change52:08 Conclusion and Final ThoughtsClick here for the transcript!Resources and Links:
Our sponsor for this episode is TImeline: Visit timeline.com, and use the discount code leewarren for 10% off your first order of MitoPure!
Sahil Bloom's Curiosity Chronicle newsletter
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Learn more about your ad choices. Visit megaphone.fm/adchoices

Jan 28, 2025 • 58min
It's Not Impossible, No Matter How it Feels (S12E20)
In this episode, Dr. Lee Warren, a brain surgeon and advocate for integrating faith and science, delves into 'Theology Monday.' He discusses the importance of combining faith and science to address life's challenges and seek the truth. Dr. Warren emphasizes that when facing seemingly insurmountable problems, faith can offer the support science cannot. He explores how God routinely accomplishes the impossible and shares insights from Psalm 121 and Eugene Peterson's 'A Long Obedience in the Same Direction.' The episode encourages listeners to choose forward progress through footprints rather than creating monuments of defeat and reassures them that God can make a way through any hardship.Chapters00:00 Introduction and Self Brain Surgery00:19 Theology and Faith01:46 Theology Monday and Podcast Promotion02:44 Sponsor Message: Mitopure03:40 Science and Faith: Complementary Paths07:39 Monuments and Footprints10:06 The Power of Community14:47 The Role of Faith in Hard Times22:59 Self Brain Surgery and Upcoming Projects26:05 Facing Impossible Situations28:35 Engage Your Frontal Lobe29:26 Changing Trains of Thought31:28 Crossroads and Monuments32:25 AirDoctor Pro Sponsor Message33:45 Memories and Footprints44:19 God's Impossible Feats48:21 Change Your Mind, Change Your Life54:03 Final Thoughts and FarewellClick here for the transcript!Resources and Links:
Visit timeline.com, and use the discount code leewarren33 for 33% off your first order of MitoPure!
Visit AirDoctorPro.com and use promo code DRLEEWARREN to get UP TO $300 off today! AirDoctor comes with a 30-day money back guarantee, plus a 3-year warranty—an $84 value, free!
I’ve created a free BRAIN Goals™ Guide for you! Click here to download the guide. It will help you align your mindset to your mission and set goals to make 2025 your best year yet!
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
ABIDE Prayer method
Lectio365 app
Kari Jobe song mentioned
Eugene Peterson book mentioned (affiliate link)
Learn more about your ad choices. Visit megaphone.fm/adchoices

Jan 20, 2025 • 53min
Checking for Drift (S12E19)
In this episode, Dr. Lee Warren discusses the high failure rate of New Year's resolutions by the third week of January and introduces the concept of 'approach drift'—a deviation from our intended goals and habits. Drawing parallels from surgical practices, he explains how small, consistent checks can help us stay on course. The episode covers the pathophysiology and pharmacology of self-brain surgery, offering practical advice on using thought discipline to create lasting change. Dr. Warren also highlights the importance of maintaining good habits, checking for drift regularly, and using re-uptake inhibitors in our thought processes. Sponsored segments include Timeline and AquaTru. Key takeaways include understanding the significance of thoroughness and intentionality in our daily pursuits and making proactive adjustments to realign with our goals.Chapters00:00 Introduction and New Year Reflections02:43 Understanding Approach Drift in Surgery08:07 Applying Surgical Precision to Life Goals14:39 Practical Tips for Habit Formation19:49 Defining a Successful Year24:53 Inspiration from Seth Godin25:21 Reflecting on Personal Goals25:51 Seth Godin's Insight: Does It Work?26:43 Aligning Actions with Intentions28:12 Overcoming Mental Barriers31:21 The Importance of Intentionality38:22 Pathophysiology and Self Brain Surgery46:58 Implementing Change and Moving ForwardClick here for the transcript!Resources and Links:
Sponsors:
TImeline: Visit timeline.com, and use the discount code leewarren33 for 33% off your first order of MitoPure!
Aquatru: Visit aquatru.com and use discount code DRLEEWARREN for 20% discount on any Aquatru water filtration system!
I’ve created a free BRAIN Goals™ Guide for you! Click here to download the guide. It will help you align your mindset to your mission and set goals to make 2025 your best year yet!
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Learn more about your ad choices. Visit megaphone.fm/adchoices

Jan 13, 2025 • 49min
War Stories #1: Going to War (S12E18)
Welcome to the first episode of our new War Stories series. This week, Dr. Lee Warren takes us back to 2004, sharing his experiences as a combat neurosurgeon deployed to the Iraq war. From personal challenges to professional fears, Dr. Warren explores the parallels between literal war and the battles we all face in life—whether they come as trauma, tragedy, or unexpected challenges.He shares lessons on preparation, resilience, and how the process of self-brain surgery can help us recover, rebuild, and thrive. If you’re looking for tools to help you face life’s challenges with hope and strength, this episode is for you.Click here for the transcript!What You’ll Learn in This Episode:
The parallels between war and personal challenges.
Why preparation (“prehab”) is essential for resilience.
Lessons from deployment that apply to life’s battles.
How to use gratitude and mindset shifts to reframe hardship.
The importance of community, faith, and self-brain surgery in overcoming adversity.
Resources Mentioned:
Hope Is the First Dose by Dr. Lee Warren
No Place to Hide by Dr. Lee Warren
Dr. Lee Warren’s Newsletter: drleewarren.substack.com
Timeline’s Mitopure: timeline.com – Use code drleewarren for 10% off.
Connect with Dr. Lee Warren:
Website: drleewarren.com
Instagram: @drleewarren
Podcast: Subscribe wherever you listen to podcasts!
Chapters00:00 Introduction and Podcast Overview00:34 Reflecting on 20 Years Since Deployment01:17 Lessons from the Iraq War02:14 Applying Self Brain Surgery to Life's Battles02:36 First War Story: Receiving Orders03:50 Sponsor Message: Timeline05:17 Preparing for Deployment08:11 Facing the Unknown in Combat11:32 Emotional and Personal Struggles12:37 Types of Wars: Expected vs. Unexpected13:27 Prehab: Preparing for Known Battles16:46 Orders in Hand: Emotional Preparation20:32 The Importance of Preparation23:12 Biblical Perspective on Life's Struggles24:09 Finding Faith in Hard Times24:34 Preparing for Life's Challenges24:59 Defining Your Belief System26:04 Building Resilient Relationships26:19 The Importance of Mental Preparation26:47 Daily Gratitude Practice28:32 Facing Life's Inevitable Wars28:50 Planning for Potential Marital Issues30:58 Financial Preparedness32:32 Personal War Stories35:46 The Impact of War on Personal Growth38:14 The Power of Sharing War Stories40:07 The Role of Faith and Community43:53 Conclusion: Embracing Hope and ChangeThis episode was sponsored by Timeline.Mitochondrial dysfunction as we age has been linked to muscle dysfunction, metabolism, overall energy levels, and resiliency. But what makes our mitochondria fail as we get older? It turns out to be related to a disruption in a process called mitophagy, the natural repair and recycling process that normally rebuilds and recreates healthy mitochondria to replace damaged ones. When mitophagy fails, mitochondria lose efficiency and cannot do their jobs, and we have a power failure. The compound that's key to keeping mitophagy happening normally is called Urolithin-A, and that compound is lacking in most of us because of a change over time in our gut microbiota. Timeline is renewing this process and making our mitochondria better with their product Mitopure. It will help you repair your cells, increase your strength, and become healthier. Check it out at timeline.com, and use the discount code leewarren for 10% off your first order.Resources and Links:
I’ve created a free BRAIN Goals™ Guide for you! Click here to download the guide. It will help you align your mindset to your mission and set goals to make 2025 your best year yet!
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Connect with me on Instagram @drleewarren
Learn more about your ad choices. Visit megaphone.fm/adchoices

Jan 6, 2025 • 40min
Science Spotlight #1: Dr. Anurag Singh on Mitochondria and Aging (S12E17)
In this inaugural Science Spotlight episode of 2025, Dr. Lee Warren dives deep into the world of mitochondrial health. He introduces the concept of 'Mitochondria Monday,' focusing on the importance of maintaining mitochondrial function for longevity and wellness as we age. Joined by Dr. Anurag Singh from Switzerland, an expert in cellular regeneration and mitochondrial health, they discuss the role of mitophagy, the groundbreaking molecule urolithin A, and its potential to rejuvenate and repair cells. The discussion includes the latest scientific findings, practical health tips, and an introduction to MitoPure, a product from Dr. Singh's company, Timeline, aimed at enhancing mitochondrial function. This episode provides valuable insights into how to proactively nurture your body for improved health and longevity.Click here for the computer-generated transcriptChapters00:00 Introduction to 2025 and Science Spotlights00:34 Understanding Mitochondria01:14 The Aging Process and Mitochondria02:57 Introducing Urolithin A04:48 Interview with Dr. Anurag Singh05:23 Dr. Singh's Background and Research09:15 Mitochondria and Aging12:32 Gut Health and Mitochondria15:01 Urolithin A and Muscle Health19:49 Brain Health and Urolithin A25:49 Timeline and MitoPure Products31:26 Conclusion and Health TipsThis episode was sponsored by Timeline.Mitochondrial dysfunction as we age has been linked to muscle dysfunction, metabolism, overall energy levels, and resiliency. But what makes our mitochondria fail as we get older? It turns out to be related to a disruption in a process called mitophagy, the natural repair and recycling process that normally rebuilds and recreates healthy mitochondria to replace damaged ones. When mitophagy fails, mitochondria lose efficiency and cannot do their jobs, and we have a power failure. The compound that's key to keeping mitophagy happening normally is called Urolithin-A, and that compound is lacking in most of us because of a change over time in our gut microbiota. Timeline is renewing this process and making our mitochondria better with their product Mitopure. It will help you repair your cells, increase your strength, and become healthier. Check it out at timeline.com, and use the discount code leewarren33 for 33% off your first order.Resources and Links:
Journaling is a helpful tool to specifically lay out your BRAIN goals, the action steps you need to reach them, and keep track of your progress. I use this PRODUCTIVE WEEKS planner* to map out my projects, podcasts, and books. I used it every day in 2024 as I sketched out and wrote my upcoming book, The Self-Brain Surgery Handbook.
I’ve created a free BRAIN Goals™ Guide for you! Click here to download the guide. It will help you align your mindset to your mission and set goals to make 2025 your best year yet!
Be sure to check out my latest book, Hope Is the First Dose!
Sign up for my weekly Self-Brain Surgery Newsletter here!
Learn more about your ad choices. Visit megaphone.fm/adchoices
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