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The Orthogonal Bet

Latest episodes

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Apr 2, 2025 • 40min

Nadia Asparouhova on ANTIMEMETICS

Join Nadia Asparouhova, a tech writer and thinker, as she sheds light on her intriguing new book about antimemetics. Discover why some ideas resist virality and how this relates to public versus private discourse. She delves into the contrast between supermemes and antimemes, comparing them to dark matter that influences behavior subtly. The conversation also touches on the tech industry as a distinct social class and the evolving landscape of tech philanthropy, sparking a deeper understanding of the dynamics shaping our digital interactions.
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Mar 26, 2025 • 41min

Alex Soojung-Kim Pang on REST & SHORTER

In this episode, Samuel Arbesman speaks with Alex Pang, author of several influential books on rethinking work—particularly how we rest and why spending less time in the office can lead to greater productivity. Pang’s most recent works include REST: Why You Get More Done When You Work Less and SHORTER: Work Better, Smarter and Less—Here’s How. His work focuses deeply on the four-day workweek, and he collaborates with 4 Day Week Global to promote a more sustainable and balanced approach to labor.Together, Samuel and Alex explore the origins of Alex’s interest in rest and productivity, his thoughts on meaning and leisure, and why we should take our downtime seriously. Their conversation touches on how time itself opens up choice and freedom, and Alex’s vision for a better future of work and life. They also delve into how these ideas are received—or often ignored—in the startup world, and how many only begin to embrace them after reaching a breaking point.Produced by⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Christopher Gates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Music by Suno
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Mar 19, 2025 • 41min

Lawrence Lundy-Bryan on how data-driven VC is over

In this episode, Samuel Arbesman speaks with Lawrence Lundy-Bryan, a partner at the venture capital firm Lunar Ventures who specializes in researching the landscape of cutting-edge technological advances. Lawrence has been examining technologies as part of a project called the State of the Future, providing analyses into a large number of new technological developments.And the current state of AI is freaking him out. In a recent essay titled "data-driven VC is over," Lawrence looks at how the new AI research tool Deep Research basically can do everything he used to do. This has prompted Lawrence to think about his work, and work and meaning more broadly, which he has also explored in further essays.Samuel and Lawrence discuss the nature of research in the world of venture capital and the shock of using Deep Research. They examine how to think about AI when it takes away not only work you are good at, but something you enjoy and love doing. They talk about the future of venture capital in an age of research democratization and the role of secret knowledge, taste, and wisdom, as well as how people have responded to Lawrence's essay. They even explore broader future implications, including youth unemployment and how education might need to be rethought.
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Mar 12, 2025 • 38min

Nadia Drake on The Arecibo Message our "Selfie of Humanity"

On November 16, 1974, the first message meant for the stars was broadcast into space, using a series of zeros and ones to encode an image. This image was designed by Frank Drake, an astronomer who helped develop the modern field of SETI as well as the Drake Equation, a formula which helps scientists think about the likelihood of intelligent life in our galaxy.Fifty years later, the science journalist Nadia Drake, who is also the daughter of Frank Drake, wrote an essay for Scientific American about this message.In this episode Samuel Arbesman had the pleasure to speak with Nadia about this Arecibo Message. Nadia is a freelance science journalist and former contributing writer at National Geographic. Nadia and Samuel had a chance to discuss the nature of the Arecibo message and how this "selfie for humanity" was designed by her dad. They talked about SETI more broadly, as well as the wisdom of sending messages into outer space. They talked about other messages sent on behalf of humanity, as well as the nature of technosignatures more generally. They even discussed how the detection of extraterrestrial intelligence might change our lives, or not, and how we think about the world.Produced by⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Christopher Gates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Music by Suno
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19 snips
Mar 5, 2025 • 49min

Niko McCarty on Building Asimov Press and Writing for Ambitious Readers

Niko McCarty, the founding editor of Asimov Press, shares his journey from biology and science journalism to leading a revolutionary publication. He discusses the unique blend of science fiction with rigorous scientific writing to engage a diverse audience. The conversation dives into groundbreaking biotech advancements, including the ethical innovations in the chicken industry, which aim to reduce male chick disposal. Niko also explores the future of biotechnology, emphasizing the transformative potential of new measurement technologies and AI in biological research.
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Feb 15, 2025 • 40min

Dave Jilk on AI, Poetry, and the Future of AGI

In this episode, host Samuel Arbesman speaks with ⁠Dave Jilk⁠. Dave is a tech entrepreneur and writer. He’s done a ton: started multiple companies, including in AI, published works of poetry, and written scientific papers. And he’s now written a new book that is an epic poem about the origins of Artificial General Intelligence, told from the perspective of the first such entity. It’s titled ⁠Epoch: A Poetic Psy-Phi Saga⁠ and is a deeply thoughtful humanistic take on artificial intelligence, chock-full of literary allusions.Sam wanted to speak with Dave to learn more about the origins of Epoch as well as how he thinks about AI more broadly. They discussed the history of AI, how we might think about raising AI, the Great Filter, post-AGI futures and their nature, and whether asking if we should build AGI is even a good question. They even finished this fun conversation with a bit of science fiction recommendations.Produced by ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Christopher Gates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Music by Suno
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17 snips
Feb 15, 2025 • 40min

Henry Oliver⁠ on Embracing Second Acts

Henry Oliver, author of "Second Act," inspires listeners with insights on late bloomers who find success later in life. He defines the traits of these individuals and discusses how society often overlooks their potential. Exploration of career reinvention after 50 emphasizes the valuable experiences late bloomers bring. The conversation challenges myths of cognitive decline and redefines retirement as a phase for new passions. Historical examples, like Margaret Thatcher and Ray Kroc, illustrate that it’s never too late for a second act.
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Feb 15, 2025 • 42min

Dominic Falcao on How Deep Science Ventures Redefines Deep Tech Innovation

In this episode, host Samuel Arbesman speaks with Dominic Falcao, a founding director of Deep Science Ventures (DSV), which he created in 2016 after leading Imperial College London’s science startup program. Deep Science Ventures takes a principled and problem-based approach to founding new deep tech startups. They have even created a PhD program for scientists specifically geared towards helping them create new companies.Sam wanted to speak with Dom to discuss the origins of Deep Science Ventures, as well as how to think about scientific and technological progress more broadly, and even how to conceive new research organizations.Dom and Sam had a chance to discuss tech trees and the combinatorial nature of scientific and technological innovation, non-traditional research organizations, Europe’s tech innovation ecosystem, what scientific amphibians are, and the use of AI in the realm of deep tech.Produced by ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Christopher Gates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Music by Suno
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Feb 15, 2025 • 45min

⁠Max Bennett on A Brief History of Intelligence

In this episode, host Samuel Arbesman speaks with writer, researcher, and entrepreneur⁠ Max Bennett⁠. Max is the cofounder of multiple AI companies and the author of the fascinating book ⁠A Brief History of Intelligence⁠: Evolution, AI, and the Five Breakthroughs That Made Our Brains. This book offers a deeply researched look at the nature of intelligence and how biological history has led to this phenomenon. It explores aspects of evolution, the similarities and differences between AI and human intelligence, many features of neuroscience, and more.Produced by ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Christopher Gates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Music by Suno
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Feb 15, 2025 • 38min

⁠Lev Grossman on The Role of Complexity in World-Building

In this episode, host Samuel Arbesman speaks with novelist ⁠Lev Grossman⁠. A longtime fan of Lev’s novels, the host delves into his works, including ⁠The Magicians trilogy⁠—a splendid set of books about a university for magic, fantastical worlds, and much more. These books are amazing. Lev’s newest book is the novel ⁠The Bright Sword⁠, a retelling of the legends of King Arthur, particularly focusing on what happens after Arthur dies.The Sam devoured The Bright Sword and found it fascinating. It’s a book that weaves together ideas about gods and magic, the layering of myths across history, and much more—all topics explored in the conversation with Lev.Lev and Sam discuss the story of King Arthur, its gaps and its history, the layering of gods and stories over time, the nature of magic and religion, the importance of secondary worlds, and the magic in The Magicians versus the magic of The Bright Sword. They even have a chance to discuss Lev’s next project, which is a space opera. This episode was a lot of fun.Produced by ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Christopher Gates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Music by Suno

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