The number of ways that observational epidemiology is misinterpreted never ceases to amaze me. I wanted to make a video about this and truly explain in detail healthy user bias and unhealthy user bias, as well as why these two things can be such fatal confounders in this type of study. By contrasting epidemiology from the West and East, this becomes more apparent, and studies done on the UK cohort in this video illustrate that epidemiology seems to be telling us more about how beneficial healthy behaviors like exercise and avoiding alcohol and smoking are rather than eating meat vs vegetables. If you or someone you know has been misled by the mainstream reporting of epidemiology you need to watch and share this video!    Check out heartandsoil.co if you need more nose to tail nutrition in your life. The JRE show notes are there as well.  

Dr Jaime Seeman is a board certified  Obstetrician and Gynecologist practicing in Omaha, Nebraska. Born and raised in the state she played collegiate softball for the Cornhuskers. She has a Bachelor of Science degree in Nutrition, Exercise and Health Sciences. She then went on to graduate medical school and completed her OBGYN residency at The University of Nebraska Medical Center. She currently is in private practice at Mid City OBGYN offering a full range of services in obstetrics, gynecology, robotic surgery and primary care. She is a fellow in Integrative Medicine at The University of Arizona School of Medicine. She is one of the first board certified ketogenic nutrition Specialists in the country. She has a passion for fitness, preventative medicine and ketogenic therapy not only in her medical practice but in her own life. She is married to her husband Ben, a police Sargent and has three young daughters. Dr Seeman is also Mrs Nebraska 2020, will compete for Mrs America in January and appeared on NBC Titan games with Dwayne “The Rock” Johnson.  Time stamps: 0:10:46   Jaimee Seeman on the Titan Games 0:14:37   Infertility outlined 0:25:01   The effect of vegetarianism on male fertility 0:27:47   How high fiber diets tank estrogen levels 0:36:46   How the omega 3:6 ratio influences ovarian and sperm health 0:39:42   How to properly use birth control 0:44:38Constructing a fertility-optimization diet 0:51:22   Riboflavin Lowers Homocysteine in Individuals Homozygous for the MTHFR 677C→T Polymorphism   https://www.ahajournals.org/doi/full/10.1161/circulationaha.105.580332 0:52:10   Why you should drop your prenatal supplement 0:55:20   Should you worry about too much liver during pregnancy?   0:55:20   Should you worry about eating too much liver during pregnancy?    0:55:20   Should you worry about eating too much liver during pregnancy? 0:58:31   The impossibility of proper vegetarian nourishment   1:03:10   Nutritional considerations for pregnancy  1:05:01       Nutritional Considerations for Pregnancy                                                                     5 min clip 1:05:42  Hyperglycemia and Adverse Pregnancy Outcomes   https://www.nejm.org/doi/full/10.1056/nejmoa0707943 1:07:00   Ketones, carbohydrates, and pregnancy 1:14:57   Postpartum and breastfeeding 1:14:57   Effect of dietary macronutrient composition under moderate hypocaloric intake on maternal adaptation during lactation   https://academic.oup.com/ajcn/article/89/6/1821/4596837 1:26:12   Nutritional support for perimenopause  1:32:14   The details on hormone replacement therapy 1:36:15   How men can best ward off prostate complications 1:36:55   How polyphenols affect estrogen metabolism 1:38:58   Getting enough magnesium 1:40:13Glycine is vital in pregnancy (preve

Is high cholesterol always a bad thing? I say no! Context matters greatly here, as in are you metabolically healthy? Do you know how to assay this? Many people eating an ancestral type diet like carnivore, carnivore-ish, keto, paleo, etc.  (like me!) will see LDL rise, but I don't believe this is a bad thing if we are insulin sensitive/metabolically healthy- this is the importance of context. I discuss the importance of considering context in discussions of LDL, Lp (a), uric acid, and APOE4 in this video. Get ready for a wild ride.  #theremembering  Check out heartandsoil.co if you need more nose to tail nutrition in your life. The JRE show notes are there as well.  

Dr. Nadir Ali is an interventional cardiologist with over 25 years of experience. He is also the chairman of the Department of Cardiology at Clear Lake Regional Medical Center. Before working as a cardiologist, he served as an assistant professor of medicine for eight years at Baylor College of Medicine in Houston, where he also received his medical training.   Time Stamps: 0:09:44  Podcast Begins 0:11:00  Lifestyle change and the power of animal foods 0:16:38  Is red meat killing us?   0:19:32  Humans are not hebivores  0:24:31  The problem with mainstream cardiology 0:31:03  The full story of LDL [and oxidized LDL] 0:38:22  Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)  https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 0:43:23  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/  0:43:50  Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients  https://www.sciencedirect.com/science/article/abs/pii/S0009308497000959?via%3Dihub 0:44:44  Linoleic acid is at the root of heart disease   0:50:08  LDL and immune health 0:58:06  Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors  https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196 1:00:11  Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease  https://www.nejm.org/doi/full/10.1056/nejmoa1615664 1:02:05  Serious adverse events and deaths in PCSK9 inhibitor trials reported on Clinical  Trials.gov: a systematic review  https://www.tandfonline.com/doi/full/10.1080/17512433.2020.1787832 1:02:56  The dark truth of PCSK9 inhibitors 1:05:12  Metabolic health is what matters   1:07:04  Metabolic health is what matters   1:08:07  Let' change the paradigm! 1:13:21  Dr. Nadir Ali's health

Meat and Organs cause gout, right? Not so fast sea bass! In this controversial thoughts video, I break it all down and discuss how CONTEXT is again critical here and how Western Medicine is myopic in its view of gout. Hint: it's all about metabolic dysfunction, like so many other things! Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life! Send me an email at drpaul@heartandsoil.co if you have questions about diet/organs!  

Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop.   Time Stamps:   0:08:42  Podcast Begins 0:09:52  Peter's Background 0:16:36  The Electron Transport Chain 0:45:30  Insulin resistance is a cellular antioxidant defense mechanism   https://www.pnas.org/content/106/42/17787 0:47:50 High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates   https://www.researchgate.net/publication/5929069_High_rates_of_superoxide_production_in_skeletal-muscle_mitochondria_respiring_on_both_complex_I-_and_complex_II-linked_substrates 0:49:50  We need insulin resistance 0:54:53  All about a1a 1:00:37  How PUFAs affect mitochondria 1:02:40  PUFAs and cellular lipid accumulation 1:05:34  Pathological insulin sensitivity   1:07:52  Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4  https://www.sciencedirect.com/science/article/abs/pii/S1388198107002296?via%3Dihub 1:12:34  The center of metabolic health: the adipocytes  1:14:08  PUFAs and tumor growth 1:15:52  Eating the perfect ratio of fatty acids 1:20:18  Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets  https://academic.oup.com/jcem/article/89/4/1641/2844241 1:20:18  How PUFAs break your metabolism 1:23:20  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 1:25:21  Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ 1:30:16  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/

What does bloodwork look like on a Nose to Tail Carnivore diet? Find out in this detailed video in which I review @KarnivoreKurt 's bloodwork with him and add detailed commentary. Spoiler alert: It looks amazingly good because animal-based diets are what humans are designed to eat! Check us out at www.heartandsoil.co if you need more nose to tail nourishment in your life! Welcome to The Remembering...    Firestarter and Gut & Digestion are out now in addition to Beef Organs and Bone Marrow & Liver. Blood Builder and Histamine & Immune are out now as well!  Yeehaw!  

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be  amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.    He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.   Time Stamps:   0:08:46  Podcast Begins 0:14:21  The Bradford Hill Criteria 0:15:29  Context matters in lipids 0:19:44  Carnivore MD's Lipid Panel 0:30:15  Why LDL can't be the root cause of CVD 0:35:57  Testing the Lipid Hypothesis  0:41:20  Why you can't look at LDL in a vacuum 0:47:38 High-density lipoprotein as a protective factor against coronary heart disease The Framingham study - The Framingham Study  https://www.amjmed.com/article/0002-9343(77)90874-9/pdf 0:49:19  Metabolic health is what really matters 0:52:01  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:54:19  LDL quality is what actually matters 1:00:39  What's the root cause of oxidized LDL?   1:06:20  Why most LDL lab tests are bonk! 1:07:41  Dave's latest experiment results 1:16:12  Summary of Dave's Energy Model 1:21:21  The body holds onto and reuses cholesterol. 1:24:28  The vital importance of ample cholesterol 1:25:40  Fasting Increases Serum Total Cholesterol, LDL Cholesterol and Apolipoprotein B in Healthy, Nonobese Humans  https://academic.oup.com/jn/article/129/11/2005/4721856 1:26:19  Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis ­Despite Highly Elevated Plasma Lipids during Hibernation and Active State  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439871/ 1:28:40  Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients 

In case you needed more reasons to love Suet (and tallow) allow me to share with you a few more studies showing some really cool benefits including colon cancer prevention in animal models, and odd chain fatty acids like C:15 (pentadecanoic acid) which appear to have significant health benefits that are found only in animal foods! Nose to tail for the win yet again!    Welcome to The Remembering...    Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life!  

Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then.   Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life.   The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable, but treatable in the early to moderate stages, with an ancestral diet.   Time stamps:   0:11:08 Podcast Begins 0:12:15 Chris Knobbe's Background 0:19:07 The History of macular degeneration and human diets 0:37:32 Chronic illness and obesity was once virtually nonexistent  0:48:41 When did PUFAs come onto the scene? 0:55:40 Increase in adipose tissue linoleic acid of US adults in the last half centuryhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/ 0:57:18 Is olive oil healthy? 0:58:47 PUFA's are the cause of chronic illness 1:02:29 The best health advice anyone could give 1:09:35 Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Micehttps://www.researchgate.net/publication/265650090_Dietary_Stearic_Acid_Leads_to_a_Reduction_of_Visceral_Adipose_Tissue_in_Athymic_Nude_Mice 1:14:41 Why you need animal fats 1:17:32 Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in micehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180905/ 1:18:41 Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colonhttps://pubmed.ncbi.nlm.nih.gov/15572298/ 1:21:56 Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ 1:23:26 Fat and essential fatty acid in mammary carcinogenesishttps://academic.oup.com/ajcn/article-abstract/45/1/218/4694942?redirectedFrom=fulltext