Age Less / Live More

The iconic brand Tupperware filed for bankruptcy this week, burdened with over $1.2 billion of debt. They’ve reached a point of no return, where digging out is virtually impossible. In many ways, this mirrors the struggle of those facing severe obesity—a situation where years of weight gain have led to a seemingly insurmountable challenge. Just as companies can file for Chapter 11 and start afresh, people now have a potential reset button with the advent of weight loss drugs like semaglutide. In this week’s podcast, I’ll delve into this rapidly evolving landscape and what it could mean for those facing their own weight loss bankruptcy. Listen and learn: How diabetes drugs are being used for weight loss and why Are diabetics missing out because of this trend? What are the safety concerns and risks of these new drugs? What happens when you stop using them? The risks vs rewards of long-term use Navigating the costs and practical considerations Like the Show? Leave us a review Check out our YouTube channel

Dr. Jesse Rissman, an Associate Professor at UCLA specializing in brain imaging and memory research, dives into the fascinating world of neuroscience. He discusses why memory is complex and nearly impossible to pinpoint in the brain. Rissman also compares human recall to that of primates and explores how theta wave stimulation could enhance memory. Additionally, he highlights the challenges of attention in our distraction-filled age and shares insights on innovative memory improvement strategies.

Dr. Richard Allsopp, an assistant professor at the University of Hawaii, focuses on telomeres and aging. He dives into the difference between biological and chronological age, explaining how telomeres function as protective caps on chromosomes. The conversation explores the role of the FOXO3 gene in longevity and the crucial enzyme telomerase in aging. Lifestyle choices impacting telomere length are emphasized, alongside strategies for potentially reversing telomere shortening, making for an insightful discussion on health and aging.

Dr. Ketema Paul, a researcher at UCLA, delves into the intriguing world of sleep and its vital role in health. He discusses why some people struggle with sleep patterns and how irregular work schedules affect well-being. The conversation covers the impact of aging on sleep quality and the advantages of consulting specialists for sleep issues. Dr. Paul also evaluates the effectiveness of sleep tracking technologies, emphasizing the need for both objective and subjective measures in understanding individual sleep health.

Inside your gastrointestinal tract there are trillions of microbes, about 3 lbs in total, and in terms of absolute numbers, you have more microbial cells than human cells. This collection of bacteria, viruses, and fungi are collectively referred to as your gut microbiome, and at this juncture of human history, most of us struggle with some degree of gut dysbiosis. My guest on this week’s podcast has dedicated his work to the study of gut microbiome and how to fix it when things go wrong. Listen and learn: Why most probiotics haven’t been tested on humans How specific strains are required for specific problems Whether stool tests are really worth it The future of fecal transplants and poop banking ABOUT OUR GUEST Dr. Gregor Reid is a microbiologist whose work is focused on human microbiome and probiotics. He’s authored over 500 scientific publications and is the author of the book, Probiotics: A Story About Hope. Links www.lawsonresearch.ca Like the Show? Leave us a review Check out our YouTube channel

The way we work has changed more in the past four years than it has in the past 20. An estimated 43 percent of Americans are now working at least partially from home, artificial intelligence is making most people at least marginally more productive, and we’re all connected all of the time. This sounds good–or at least exciting–but is it working for you? Are you more efficient? More balanced? More creative? My guest on this week’s podcast wrote a book on efficiency in our modern world, a quickly changing landscape where decade old systems and processes have become obsolete. Listen and learn: How time energy management is now more important that time management Why productivity should be measured in terms of results not total work completed How to break up your day based on your peak creative blocks Why we need to rethink the way we measure and track work Links www.MithuStoroni.com   ABOUT OUR GUEST Dr. Mithu Storoni is a medical doctor, neuroscientist, and author, best known for her work on stress and its effects on the brain. Her books include Stress Proof and her forthcoming title, Hyperefficient.  Like the Show? Leave us a review Check out our YouTube channel

Dr. Liz Lyster, an OB-GYN with over 25 years in hormonal health, dives into the realities of menopause. She reveals how hormone replacement therapy (HRT) myths, especially regarding breast cancer risks, distort women's choices. The discussion highlights the benefits of balanced hormones for sleep and bone health. Liz advocates for a patient-centered approach and discusses various HRT options, while redefining menopause as a growth opportunity. She also emphasizes the nutritional benefits of soy and the importance of fitness in enhancing health during this life stage.

Professor Paul Lee, a double board certified surgeon specializing in knee and hip surgeries, discusses innovative joint pain management. He highlights the impressive success rates of hip replacements and the complexities of knee interventions. The conversation emphasizes the importance of making informed choices about treatments like injections and cryotherapy. Professor Lee also advocates for a holistic approach to fitness, recommending balanced exercise routines to enhance joint health and overall well-being.

Dr. Helen Lavretsky, a psychiatrist and UCLA professor specializing in geriatric psychiatry, sheds light on the mental health struggles faced by those over 60, revealing that loneliness and chronic pain are significant factors. She discusses the aging brain's shifts and the challenges of polypharmacy. Fascinatingly, Dr. Lavretsky emphasizes the uplifting power of music, chanting, and mind-body practices like yoga, highlighting their benefits for mental well-being and cognitive health in later life.

In middle age and beyond, your metabolism changes. It’s easier to gain weight - particularly around your midsection - and it’s very hard to lose it. The same foods that kept you lean when young suddenly cause imbalance. Why? What changed? Aging creates a cascade of changes, but insulin resistance is a key driver that is rarely measured or understood. On this week’s podcast, you’ll meet a health provider whose work is focused on tackling this issue, particularly in older adults. Listen and learn: Why fasting insulin tests are not common but easy to get Why we have less wiggle room, metabolically in middle age and beyond How stress, sleep, and nutrition all play a role in metabolic dysfunction Why your standard blood work might miss insulin resistance Links Dr. Nolte’s Site ABOUT OUR GUEST Dr. Morgan Nolte is a geriatric physical therapist and the founder of Zivli an organization that helps people reverse insulin resistance and lose weight.  Like the Show? Leave us a review Check out our YouTube channel