The Stem Cell Podcast

Dr. Robert Zweigerdt, a Principal Investigator at Hannover Medical School, revolutionizes heart research through his work on cardiac differentiation and heart-forming organoids. He explains how these organoids mirror heart development and discusses their potential for regenerative medicine. The conversation also touches on the significance of mentorship and international collaboration in advancing stem cell science, alongside groundbreaking advancements related to mouse embryo modeling and innovative wound healing strategies.

Dr. Giorgia Quadrato, an Assistant Professor at USC, dives into her groundbreaking work on cerebellar organoids. She shares insights on generating these organoids with functional Purkinje cells and discusses the development of a transcriptomic atlas for neural organoids. The conversation sheds light on the advancements and challenges in California's stem cell research landscape. Additionally, Quadrato highlights the potential of organoids in personalized medicine and tumor modeling, emphasizing the crucial role of collaboration and mentorship in scientific progress.

Dr. Andrew Elefanty and Dr. Elizabeth Ng, both leading researchers at the Murdoch Children’s Research Institute, dive into the captivating world of blood development. They discuss their groundbreaking study on deriving and transplanting hematopoietic stem cells. The duo shares insights on innovative tools for customizing blood stem cells and the importance of collaboration in advancing research. They also highlight the challenges of immune responses in cellular therapies and the potential of engineered tissues for treating blood-related diseases.

Dr. Marius Wernig, a renowned Professor at Stanford University, dives into his pioneering work on reprogramming neuronal cells and developing therapies for brain and skin diseases. He shares insights on the evolution of induced pluripotent stem cells and the innovations in neurological disease modeling. The conversation touches on challenges in neuron transplantation and the therapeutic potential of cell therapy for neurodegenerative conditions. Outside the lab, Wernig reveals his musical talents, showcasing a creative balance between science and art.

Dr. Jonathan Thomas, President and CEO of the California Institute for Regenerative Medicine (CIRM), shares his insights on funding vital stem cell research. He discusses the importance of diversity in clinical trials to make treatments accessible. JT reflects on CIRM's 20-year journey in advancing research and training future scientists. The conversation also dives into balancing support between basic and clinical research, along with CIRM's strategic shift post-Proposition 14 to navigate the evolving landscape of regenerative medicine.

Dr. Milica Radisic, a Professor at the University of Toronto and Canada Research Chair, dives into the innovative realm of organ chip engineering. She shares the exciting challenges of maturing cardiomyocytes using macrophages to improve cardiac tissue function. Milica discusses the sustainability issues with microfluidic chips and how her lab's models are reducing reliance on lab animals. As a burgeoning entrepreneur, she reflects on her journey and the landscape for women in business, offering valuable insights from her mentor, Dr. Bob Langer.

Dr. Cynthia Dunbar, a distinguished investigator at the NIH, dives into the fascinating world of hematopoiesis and aging, using macaques as an innovative model. She discusses groundbreaking research on transplanting iPSC-derived cardiomyocytes, alongside the ethical considerations of using primate models. The unique NIH environment fosters collaboration in stem cell research, enhancing both clinical applications and personalized medicine. Outside the lab, Cindy's musical talents add a delightful twist to her scientific journey.

Dr. Mansi Srivastava, a Professor at Harvard and Curator at the Harvard Museum of Comparative Zoology, dives into the fascinating world of whole-body regeneration using the three-banded panther worm. She reveals how her lab traces adult stem cell lineages and the worm's remarkable ability to regrow organs and even brains. The discussion highlights the importance of diverse model organisms in regenerative medicine and her outreach initiatives aimed at inspiring young scientists. Prepare for a journey through evolution, regeneration, and the future of science communication!

Dr. Bruna Paulsen, a leader in therapeutic development at Gameto, and Dr. Dina Radenkovic, co-founder and CEO, dive into revolutionary approaches to women's reproductive health. They discuss Fertilo, a groundbreaking platform that uses ovarian support cells to enhance IVF and egg freezing processes. The conversation also touches on the ethical dimensions of fertility treatments and the importance of addressing diverse patient needs. Their insights illuminate the future of assisted reproduction and the transformative potential of stem cell technology.

Dr. Meritxell Huch, Scientific Director at the Max Planck Institute, dives into her research on liver and pancreas organoid models. She details innovative co-culture techniques for liver mesenchyme and ductal cells. The conversation highlights the complexities of liver regeneration, including the potential of using Yamanaka factors for neuroprotection. Huch shares her inspiring journey across Europe, showcasing the importance of passion and support in scientific pursuits. A blend of groundbreaking science and personal determination makes for a captivating discussion.