The Stem Cell Podcast Ep. 283: “Molecular Hematopoiesis” Featuring Dr. Cynthia Dunbar
Dec 3, 2024
Dr. Cynthia Dunbar, a distinguished investigator at the NIH, dives into the fascinating world of hematopoiesis and aging, using macaques as an innovative model. She discusses groundbreaking research on transplanting iPSC-derived cardiomyocytes, alongside the ethical considerations of using primate models. The unique NIH environment fosters collaboration in stem cell research, enhancing both clinical applications and personalized medicine. Outside the lab, Cindy's musical talents add a delightful twist to her scientific journey.
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Non-Human Primate Models in Hematopoiesis Research
- Dr. Dunbar's lab uses non-human primate models to understand human hematopoiesis and aging.
- These models offer insights not readily available from rodent studies, especially regarding clonal hematopoiesis and somatic mutations.
Balancing Hematopoiesis and Cancer Risk
- Hematopoiesis is remarkable for its ability to produce billions of diverse cells daily without cancerous transformation.
- The challenge lies in understanding age-related changes and their impact on stem cell therapies, balancing benefits with cancer risks.
Early Gene Therapy Trials
- Dr. Dunbar recounts early gene therapy trials for sickle cell disease in the 1980s, highlighting the limitations of in vitro and mouse models.
- These early trials failed because the assays used didn't predict long-term engraftment in humans.