The Stem Cell Podcast

Ep. 287: “Blood Development” Featuring Drs. Andrew Elefanty and Elizabeth Ng

Feb 4, 2025
Guest
Elizabeth Ng
Guest
Drs. Andrew Elefanty
Dr. Andrew Elefanty and Dr. Elizabeth Ng, both leading researchers at the Murdoch Children’s Research Institute, dive into the captivating world of blood development. They discuss their groundbreaking study on deriving and transplanting hematopoietic stem cells. The duo shares insights on innovative tools for customizing blood stem cells and the importance of collaboration in advancing research. They also highlight the challenges of immune responses in cellular therapies and the potential of engineered tissues for treating blood-related diseases.
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INSIGHT

Embryonic Guidance

  • The Elefanty/Ng/Stanley lab prioritizes modeling embryonic development to guide their research.
  • They use reporter cell lines to objectively measure in vitro models, validating their tools and sharing them widely.
ADVICE

Sharing is Caring

  • Share reagents and technologies with collaborators and other researchers.
  • This validates tools, fosters collaboration, and leads to new insights.
INSIGHT

HOXA Patterning

  • The lab's HSC derivation success stems from understanding developmental hematopoiesis, particularly HOXA gene expression.
  • Correct patterning of mesoderm from the start is crucial, as early errors cannot be reversed.
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