Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation
David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist
The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?There's a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver your groundbreaking therapy to clinics and market without delay, and still enjoy every single step.I'm David Brühlmann, a biotech entrepreneur and strategic advisor who partners with C-level biopharma leaders to tackle one of our industry's biggest challenges: reducing manufacturing costs to make lifesaving therapies accessible to more patients worldwide.Through engaging conversations with industry pioneers and practical insights from the trenches, this podcast tackles the critical challenges in bioprocess CMC development and manufacturing of recombinant proteins and cell and gene therapy products. We cut through the complexity so you can:Master bioprocess development with confidence and clarityExcel at scale-up and manufacturing of biologicsTransform your innovative therapy and manufacturing technology into market-ready solutions fasterOptimize manufacturing costs without compromising qualityMake data-driven decisions that reduce the risk of failureI can’t wait to help you do biotech the smart way.Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.Ready to transform your biomanufacturing journey? Let's dive in!Next Steps:Book a free call to reduce biomanufacturing costs and make lifesaving therapies more accessible: https://bruehlmann-consulting.com/call🧬 Ready to accelerate your IND timeline? Get the proven CMC Dashboard that's guided successful mAb programs from chaos to submission: https://stan.store/SmartBiotech/p/cmc-dashboard-for-biotech-foundersAccelerate biologics development with expert guidance: https://bruehlmann-consulting.comFor sponsorship opportunities, contact us at hello@bruehlmann-consulting.comVisit the Website: https://smartbiotechscientist.comEmail us: hello@bruehlmann-consulting.com
Episodes
Mentioned books
Apr 30, 2024 • 17min
49: Decode Bioprocess Success: The Art of Stakeholder Management - Part 1
In this episode, we embark on a journey to uncover the essential strategies for navigating stakeholder relationships in bioprocess CMC development projects.We delve into the critical role of stakeholders in bioprocess development and how their engagement can determine the success or failure of a project. Drawing from real-life experiences and insights, we explore the importance of understanding stakeholder needs, interests, and power dynamics.Discover why stakeholder management is not just a skill but an art form essential for unlocking bioprocess success. Join us as we unravel the complexities of stakeholder engagement and provide actionable tips for mastering this crucial aspect of bioprocess development.Tune in to learn how decoding the dynamics of stakeholder management can lead to triumph in bioprocess projects.Next Step:Boost your bioprocess strategy! Book your free assessment for success: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 25, 2024 • 19min
48: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 2
Unlock the secrets to cost-efficient antibody therapeutics with Brian Kelley, Senior Vice President of Process Development at VIR Biotechnology.In this illuminating episode, industry expert Brian Kelley shares invaluable insights into driving down manufacturing costs while maintaining quality and accessibility. From optimizing batch sizes to maximizing titers, discover practical strategies to streamline the process economics of antibody development.Key Takeaways:Scale Matters: Learn how economies of scale play a pivotal role in minimizing manufacturing costs, paving the way for global accessibility of life-saving therapies.Titer Triumphs: Dive deep into the significance of maximizing titers to achieve substantial reductions in batch requirements and cost of goods, revolutionizing antibody production efficiency.Focus Innovation: Gain clarity on where to direct innovation efforts, balancing established manufacturing practices with groundbreaking developments in emerging modalities like cell and gene therapies.Join us as we unravel the future landscape of antibody production, where simplicity and innovation converge to shape the next frontier of healthcare solutions. Tune in now for actionable strategies and visionary perspectives on mastering process economics in antibody therapeutics.Connect with Brian Kelley:LinkedIn: https://www.linkedin.com/in/brian-kelley-3389375Next Step:Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 23, 2024 • 17min
47: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 1
Join us in this enlightening episode as we explore process economics with industry expert Brian Kelley. He is the Senior Vice President of Process Development at VIR Biotechnology.Unraveling the mysteries of cost management in antibody therapeutics, Brian sheds light on the intricate challenges faced by biotech scientists and engineers.Key Highlights:Discover the nuanced interplay between technical and cultural obstacles in process development.Navigate the labyrinth of cost drivers in antibody manufacturing, from raw materials to labor expenses.Learn the art of balancing speed, quality, and cost-effectiveness in bringing therapeutics to market.Tune in for a masterclass in maximizing efficiency and driving down costs in the dynamic landscape of biologics production.Connect with Brian Kelley:LinkedIn: https://www.linkedin.com/in/brian-kelley-3389375Next Step:Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 18, 2024 • 28min
46: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 2
Dive into the future of food with our latest episode, "From Lab to Table: The Science Behind Cultivated Meat." With our guest, Petra Hanga, a Lecturer in Biochemical Engineering at University College London and Chief Scientific Officer of Quest Meat Ltd., we unravel the secrets behind this groundbreaking technology.Key highlights:1. Discover how stem cells revolutionize the production of cultivated meat, providing a scalable solution for creating muscle, fat, and connective tissues.2. Explore the intricate balance of nutrients, growth factors, and environmental conditions crucial for maximizing cell growth and quality.3. Understand the challenges and breakthroughs in scaling up bioreactor processes for efficient meat production.Join us for an informative discussion on the cutting edge of food technology. Gain valuable insights into the process of transforming lab-grown cells into delectable dishes on your table.Don't miss out on this compelling episode!Connect with Petra Hanga:LinkedIn: https://www.linkedin.com/in/petrahanga/Twitter: @PetraHangaNext Step:Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment🧬 Stop second-guessing your CMC strategy. Get an investor-ready CMC roadmap in 2 weeks, before mistakes cost you $2M+ and 18 months of delays. Secure your spot here.Support the show
Apr 16, 2024 • 14min
45: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 1
Dive into the fascinating world of cultivated meat with our guest, Petra Hanga, Lecturer in Biochemical Engineering – Cellular Agriculture at University College London and the Chief Scientific Officer of Quest Meat Ltd.In this episode, Petra sheds light on the intricacies of developing cultivated meat and reveals the key hurdles biotech scientists face.Highlights:Learn how scientists tackle the complexity of replicating animal meat, ensuring a truly authentic taste and texture for future meat alternatives.Gain insight into the innovative solutions shaping the future of sustainable protein sources.Discover the potential of cultivated meat to revolutionize our food system.Join us as we explore the promising landscape of cultivated meat, where science and innovation converge to shape a more sustainable future.Enjoy your listening!Connect with Petra Hanga:LinkedIn: https://www.linkedin.com/in/petrahanga/Twitter: @PetraHangaNext Step:Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 11, 2024 • 18min
44: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 2
Does uncovering the secrets of glycan engineering feel like navigating a maze of molecular complexity?In this captivating continuation of our exploration into the world of glycan engineering, we delve deeper into groundbreaking innovations and the crucial role of analytics in ensuring consistent quality.Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), shares the fascinating story behind a groundbreaking technology designed to modulate antibody-dependent cell-mediated cytotoxicity (ADCC).You’ll get:Learn how advancements in high-throughput techniques are streamlining analytics for quicker insights and data-driven optimizations.Explore the future of glycan engineering, which may lead to more effective therapeutics.Understand why glycans matter across various fields of biotechnology, including monoclonal antibodies and vaccines, and discover their pivotal role in shaping the future of healthcare.Connect with Henning von Horsten:LinkedIn: https://www.linkedin.com/in/henning-von-horsten-b259102/Website: https://lsm.htw-berlin.de/team/prof-dr-rer-nat-hans-henning-von-horsten/Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 9, 2024 • 23min
43: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 1
Does unlocking the secrets of glycan engineering seem like navigating a labyrinth of molecular complexity?In this episode, we delve into the pivotal role of glycans as critical quality attributes (CQAs) in biotherapeutics.Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), sheds light on the art and science of glycan engineering and analysis.Key highlights:Discover various methods scientists are utilizing to improve glycan profiles.Get insights into the challenges and solutions of off-target effects and cellular metabolic adjustments.Learn about the exciting advancements in synthesizing ideal glycans outside living cells.Connect with Henning von Horsten:LinkedIn: https://www.linkedin.com/in/henning-von-horsten-b259102/Website: https://lsm.htw-berlin.de/team/prof-dr-rer-nat-hans-henning-von-horsten/Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 4, 2024 • 13min
42: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 2
Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around.Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing on the vital few tasks that contribute significantly to your goals, celebrating small wins, and protecting your time.We also share a powerful story that illustrates the potential of Essentialism. Discover how Essentialism is not about doing more, but doing the right things, and how this disciplined approach can lead you to significant breakthroughs in your bioprocess CMC development activities. This episode is a must-listen for any scientist and engineer who feels overcommitted, overloaded, or overworked.Tune in to learn how to navigate the complex world of biotech process development in a more strategic, efficient, and successful way.Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Apr 2, 2024 • 15min
41: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 1
Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around.Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing on the vital few tasks that contribute significantly to your goals, celebrating small wins, and protecting your time.We also share a powerful story that illustrates the potential of Essentialism. Discover how Essentialism is not about doing more, but doing the right things, and how this disciplined approach can lead you to significant breakthroughs in your bioprocess CMC development activities. This episode is a must-listen for any scientist and engineer who feels overcommitted, overloaded, or overworked.Tune in to learn how to navigate the complex world of biotech process development in a more strategic, efficient, and successful way.Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Mar 28, 2024 • 15min
40: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 2
Explore the intricate world of perfusion and its sustainability challenges in the part 2 of this episode. Dive into the operational side of managing vast quantities of media production and storage, and discover smart strategies to address these challenges.Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science, discusses the distinction between facility designs for batch and perfusion bioreactors, shedding light on the need for extensive tank farms to support perfusion.Key Insights:Explore the success of automated perfusion media preparation at the lab scale and its scaling up to a 500L capacity.Discover how advancements in small-scale perfusion operations are supercharging the perfusion process development.Get practical steps for developing a cost-efficient perfusion process.Tune in to discover how perfusion processes are revolutionizing the biotech industry and contributing to a more sustainable future.Connect with Jochen Sieck:LinkedIn: https://www.linkedin.com/in/jochenbsieckACTIP Fellowship award: https://www.actip.org/fellowshipResources:Perfusion Cell Culture Processes for Biopharmaceuticals by Moritz Wolf, Jean-Marc Bielser, and Massimo Morbidelli: https://www.cambridge.org/core/books/perfusion-cell-culture-processes-for-biopharmaceuticals/5C650AD26D52B2435E7796D382ECE5DANext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
