Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation
David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist
The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?There's a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver your groundbreaking therapy to clinics and market without delay, and still enjoy every single step.I'm David Brühlmann, a biotech entrepreneur and strategic advisor who partners with C-level biopharma leaders to tackle one of our industry's biggest challenges: reducing manufacturing costs to make lifesaving therapies accessible to more patients worldwide.Through engaging conversations with industry pioneers and practical insights from the trenches, this podcast tackles the critical challenges in bioprocess CMC development and manufacturing of recombinant proteins and cell and gene therapy products. We cut through the complexity so you can:Master bioprocess development with confidence and clarityExcel at scale-up and manufacturing of biologicsTransform your innovative therapy and manufacturing technology into market-ready solutions fasterOptimize manufacturing costs without compromising qualityMake data-driven decisions that reduce the risk of failureI can’t wait to help you do biotech the smart way.Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.Ready to transform your biomanufacturing journey? Let's dive in!Next Steps:Book a free call to reduce biomanufacturing costs and make lifesaving therapies more accessible: https://bruehlmann-consulting.com/call🧬 Ready to accelerate your IND timeline? Get the proven CMC Dashboard that's guided successful mAb programs from chaos to submission: https://stan.store/SmartBiotech/p/cmc-dashboard-for-biotech-foundersAccelerate biologics development with expert guidance: https://bruehlmann-consulting.comVisit the Website: https://smartbiotechscientist.comEmail us: hello@bruehlmann-consulting.com
Episodes
Mentioned books
Mar 7, 2024 • 11min
34: The 7 Habits of Highly Successful Innovators - Part 2
Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit.Key learnings include:The power of curiosity and how it leads to groundbreaking ideas and improvements.The importance of connecting the dots to gain new insights and see invisible relationships.The role of risk-taking in pushing boundaries and experimenting with new ideas.These insights provide a roadmap to developing your own innovative mindset and achieving success. Don't miss out on these valuable insights that could ignite your innovative spirit. Tune in now!Next Step:Elevate your biologics development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Mar 5, 2024 • 11min
33: The 7 Habits of Highly Successful Innovators - Part 1
Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit.Key learnings include:The power of curiosity and how it leads to groundbreaking ideas and improvements.The importance of connecting the dots to gain new insights and see invisible relationships.The role of risk-taking in pushing boundaries and experimenting with new ideas.These insights provide a roadmap to developing your own innovative mindset and achieving success. Don't miss out on these valuable insights that could ignite your innovative spirit. Tune in now!Next Step:Elevate your biologics development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Feb 29, 2024 • 17min
32: The Future of Glycoengineering: Trends Unveiled w/ Thomas Rexer - Part 2
Discover the hurdles and breakthroughs in glycoengineering, including the high costs of activated sugars.Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, unveils eversyn's multi-step biocatalysis process, designed to significantly drive down costs and make in vitro glycoengineering more accessible on a large scale.Key Insights:Uncover the power of multistep biocatalysis in driving down costs and making in vitro glycoengineering more accessible.Bridge the Gap between academia and industry in glycoengineering and thus ensure a smoother integration of groundbreaking glycoengineering technologies into the industrial landscape.Gain valuable insights into the challenges and triumphs of transitioning from pure science to entrepreneurship, offering aspiring scientists a roadmap to navigate the unknown.Connect with Thomas Rexer:LinkedIn: https://www.linkedin.com/in/thomas-rexerWebsite: www.eversyn.deNext Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Feb 27, 2024 • 18min
31: The Future of Glycoengineering: Trends Unveiled w/ Thomas Rexer - Part 1
Get ready for a crash course in glycoengineering as Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, breaks down the significance of modifying glycans in biopharmaceuticals.Explore the science behind glycoengineering and its potential to enhance the properties of therapeutic proteins.Key Insights:Unlock new frontiers in glycoengineeringExplore the potential of glycoengineering to revolutionize biopharmaceuticalsEnsure seamless integration of glycoengineering into production processesDon't miss this episode as Thomas unveils the trends that will shape the future of glycoengineering, offering actionable insights for scientists, entrepreneurs, and biotech enthusiasts alike.Connect with Thomas Rexer:LinkedIn: https://www.linkedin.com/in/thomas-rexerWebsite: www.eversyn.deNext Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Feb 22, 2024 • 15min
30: From Monoclonals to Gene Therapy: Tips for Biopharma Process Development w/ Neil Templeton - Part 2
In our insightful second part of the conversation, we broaden our perspective to delve into the various modalities within the biotech industry, highlighting the unique and shared aspects of process development and scale-up.Neil Templeton, the Director of Upstream Process Development at Solid Biosciences, passionately articulates his commitment towards making gene therapy more accessible. He does this by outlining strategic solutions to reduce the costs of development and manufacturing.You will gain:A comprehensive understanding of process development's similarities and differences across biologics, vaccines, and cell and gene therapy manufacturing.Effective strategies aimed at reducing the costs associated with gene therapy development and manufacturing.Insights into how capitalizing on the expertise from the biologics sector can positively impact other fields.To connect with Neil Templeton and learn more about his work, visit his LinkedIn profile.LinkedIn: https://www.linkedin.com/in/neil-templetonNext Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Feb 20, 2024 • 25min
29: From Monoclonals to Gene Therapy: Tips for Biopharma Process Development w/ Neil Templeton - Part 1
In this enlightening episode, we're joined by Neil Templeton, Director in Upstream Process Development at Solid Biosciences, who pulls back the curtain on the intricate world of bioprocess development and manufacturing.Neil delves into the shifting paradigms of the industry, sharing his expert insights on overcoming the unique challenges that surface when transitioning from R&D to GMP production. This episode is packed full of invaluable knowledge that's crucial for anyone looking to succeed in this field.Key points we discuss include:Strategies and solutions for overcoming the obstacles faced when transitioning from R&D to GMP production.The importance and application of Design of Experiment (DOE) approaches, and their role in understanding critical process parameters.The role of metabolite analysis in optimizing processes and ensuring their robustness.Get connected with Neil Templeton:LinkedIn: https://www.linkedin.com/in/neil-templetonNext Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.com🧬 Stop second-guessing your CMC strategy before investor meetings. Our 1-Week CMC Assessment reveals your roadmap gaps and transforms uncertain founders into confident presenters who ace investor meetings. Secure your assessment at https://stan.store/SmartBiotech/p/get-cmc-clarity-in-1-week--investor-readySupport the show
Feb 15, 2024 • 13min
28: How to Simplify Project Management in Bioprocess Development - Part 2
Tackling bioprocess development and scale-up can be complex. While the science might be challenging, project management within biotech doesn't have to be.In this engaging episode, we'll guide you on how to streamline your CMC development, demystifying the complexities of project planning and execution.Here's what you'll gain:Discover the secret to 'Successful Planning,' - a strategy to ensure your projects are well-organised, resource-smart, and timely delivered.Understand the crucial role of 'Assessing Scalability Potential,' and why it's a game-changer for your project's long-term success.Unleash the 'Power of a High-Performance Team,' and learn how effective leadership can enable your team to excel and achieve outstanding results.Don't allow complexity to impede your progress - join us for these insights and beyond!Next Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Feb 13, 2024 • 16min
27: How to Simplify Project Management in Bioprocess Development - Part 1
Bioprocess development and scale-up are complex. Science may give you headaches, but biotech project management should not.In this riveting episode, you'll learn how to simplify your CMC development, guiding you through the maze of project planning and execution.Key Takeaways:Uncover how to "Plan for Success," ensuring your projects are well-structured, resource-efficient, and delivered on time.Learn the importance of "Evaluating the Scalability Potential," and why it's crucial for the long-term success of your project.Discover the power of "Building a High-Performing Team," and how the right leadership can empower your team and skyrocket results.Don't let complexity hold you back - tune in for these insights and more!Next Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Feb 8, 2024 • 13min
26: 9 Critical Steps for a Seamless Transition to Large-Scale Production - Part 2
In this riveting episode of the Smart Biotech Scientist podcast, we navigate the intricate labyrinth of biotech scale-ups. We distill the process down to 9 essential steps for a smooth transition from laboratory to large-scale production.Key Insights:Acquire Comprehensive Process Understanding: Bolster your decision-making and problem-solving skills with an in-depth understanding of your process, molecule, and expertise at your disposal.Span the Technology Gaps: Tackle obstacles and boost efficiency by utilizing appropriate technology and strategic risk mitigation techniques.Develop a Detailed, Sequential Roadmap: Alleviate confusion and ensure a fluid scale-up process with a precise, well-defined roadmap.Equip yourself with the knowledge to not just endure tech transfers, but to excel.Transform the tumult of tech transfer into a harmonious symphony with our expert guidance!Next Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
Feb 6, 2024 • 19min
25: 9 Critical Steps for a Seamless Transition to Large-Scale Production - Part 1
In this enlightening episode of the Smart Biotech Scientist podcast, we delve into the complex world of biotech scale-ups. We break down the 9 crucial steps to ensure a seamless transition from lab to large-scale production.Top 3 Takeaways:Gain Comprehensive Process Understanding: Enhance your decision-making and problem-solving abilities by thoroughly understanding your process, molecule, and available expertise.Bridge the Technology Gaps: Overcome challenges and increase efficiency by leveraging suitable technology and strategic risk mitigation methodologies.Create a Clear, Step-by-Step Roadmap: Reduce confusion and facilitate a smooth scale-up process with a clear, detailed roadmap.You will be armed with the knowledge to not just survive tech transfers, but to thrive.Turn the tech transfer chaos into a well-orchestrated symphony with our expert insights!Next Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show
