Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation
David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist
The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?There's a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver your groundbreaking therapy to clinics and market without delay, and still enjoy every single step.I'm David Brühlmann, a biotech entrepreneur and strategic advisor who partners with C-level biopharma leaders to tackle one of our industry's biggest challenges: reducing manufacturing costs to make lifesaving therapies accessible to more patients worldwide.Through engaging conversations with industry pioneers and practical insights from the trenches, this podcast tackles the critical challenges in bioprocess CMC development and manufacturing of recombinant proteins and cell and gene therapy products. We cut through the complexity so you can:Master bioprocess development with confidence and clarityExcel at scale-up and manufacturing of biologicsTransform your innovative therapy and manufacturing technology into market-ready solutions fasterOptimize manufacturing costs without compromising qualityMake data-driven decisions that reduce the risk of failureI can’t wait to help you do biotech the smart way.Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.Ready to transform your biomanufacturing journey? Let's dive in!Next Steps:Book a free call to reduce biomanufacturing costs and make lifesaving therapies more accessible: https://bruehlmann-consulting.com/call🧬 Ready to accelerate your IND timeline? Get the proven CMC Dashboard that's guided successful mAb programs from chaos to submission: https://stan.store/SmartBiotech/p/cmc-dashboard-for-biotech-foundersAccelerate biologics development with expert guidance: https://bruehlmann-consulting.comVisit the Website: https://smartbiotechscientist.comEmail us: hello@bruehlmann-consulting.com
Episodes
Mentioned books
Apr 11, 2024 • 18min
44: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 2
Does uncovering the secrets of glycan engineering feel like navigating a maze of molecular complexity?In this captivating continuation of our exploration into the world of glycan engineering, we delve deeper into groundbreaking innovations and the crucial role of analytics in ensuring consistent quality.Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), shares the fascinating story behind a groundbreaking technology designed to modulate antibody-dependent cell-mediated cytotoxicity (ADCC).You’ll get:Learn how advancements in high-throughput techniques are streamlining analytics for quicker insights and data-driven optimizations.Explore the future of glycan engineering, which may lead to more effective therapeutics.Understand why glycans matter across various fields of biotechnology, including monoclonal antibodies and vaccines, and discover their pivotal role in shaping the future of healthcare.Connect with Henning von Horsten:LinkedIn: https://www.linkedin.com/in/henning-von-horsten-b259102/Website: https://lsm.htw-berlin.de/team/prof-dr-rer-nat-hans-henning-von-horsten/Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 9, 2024 • 23min
43: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 1
Does unlocking the secrets of glycan engineering seem like navigating a labyrinth of molecular complexity?In this episode, we delve into the pivotal role of glycans as critical quality attributes (CQAs) in biotherapeutics.Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), sheds light on the art and science of glycan engineering and analysis.Key highlights:Discover various methods scientists are utilizing to improve glycan profiles.Get insights into the challenges and solutions of off-target effects and cellular metabolic adjustments.Learn about the exciting advancements in synthesizing ideal glycans outside living cells.Connect with Henning von Horsten:LinkedIn: https://www.linkedin.com/in/henning-von-horsten-b259102/Website: https://lsm.htw-berlin.de/team/prof-dr-rer-nat-hans-henning-von-horsten/Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com/assessmentSupport the show
Apr 4, 2024 • 13min
42: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 2
Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around.Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing on the vital few tasks that contribute significantly to your goals, celebrating small wins, and protecting your time.We also share a powerful story that illustrates the potential of Essentialism. Discover how Essentialism is not about doing more, but doing the right things, and how this disciplined approach can lead you to significant breakthroughs in your bioprocess CMC development activities. This episode is a must-listen for any scientist and engineer who feels overcommitted, overloaded, or overworked.Tune in to learn how to navigate the complex world of biotech process development in a more strategic, efficient, and successful way.Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Apr 2, 2024 • 15min
41: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 1
Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around.Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing on the vital few tasks that contribute significantly to your goals, celebrating small wins, and protecting your time.We also share a powerful story that illustrates the potential of Essentialism. Discover how Essentialism is not about doing more, but doing the right things, and how this disciplined approach can lead you to significant breakthroughs in your bioprocess CMC development activities. This episode is a must-listen for any scientist and engineer who feels overcommitted, overloaded, or overworked.Tune in to learn how to navigate the complex world of biotech process development in a more strategic, efficient, and successful way.Next Step:Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Mar 28, 2024 • 15min
40: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 2
Explore the intricate world of perfusion and its sustainability challenges in the part 2 of this episode. Dive into the operational side of managing vast quantities of media production and storage, and discover smart strategies to address these challenges.Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science, discusses the distinction between facility designs for batch and perfusion bioreactors, shedding light on the need for extensive tank farms to support perfusion.Key Insights:Explore the success of automated perfusion media preparation at the lab scale and its scaling up to a 500L capacity.Discover how advancements in small-scale perfusion operations are supercharging the perfusion process development.Get practical steps for developing a cost-efficient perfusion process.Tune in to discover how perfusion processes are revolutionizing the biotech industry and contributing to a more sustainable future.Connect with Jochen Sieck:LinkedIn: https://www.linkedin.com/in/jochenbsieckACTIP Fellowship award: https://www.actip.org/fellowshipResources:Perfusion Cell Culture Processes for Biopharmaceuticals by Moritz Wolf, Jean-Marc Bielser, and Massimo Morbidelli: https://www.cambridge.org/core/books/perfusion-cell-culture-processes-for-biopharmaceuticals/5C650AD26D52B2435E7796D382ECE5DANext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Mar 26, 2024 • 26min
39: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 1
Explore perfusion processes and sustainability with our guest, Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science.Learn about the evolution of perfusion methodologies, its historical roots in addressing product stability, and its recent return to continuous and integrated manufacturing.Jochen discusses the economic and strategic reasons behind perfusion's resurgence, emphasizing the need for flexible, smaller-scale facilities.Key Learnings:Gain insight into the environmental impact of traditional facilities and the potential benefits of alternatives.Dive deep into the balance of cost, productivity, and sustainability in media consumption.Discover strategies for optimizing perfusion rates and sustainability.Get ready to expand your understanding of perfusion processes, sustainability, and the delicate dance between economics and environmental consciousness.Connect with Jochen Sieck:LinkedIn: https://www.linkedin.com/in/jochenbsieckACTIP Fellowship award: https://www.actip.org/fellowshipResources:Perfusion Cell Culture Processes for Biopharmaceuticals by Moritz Wolf, Jean-Marc Bielser, and Massimo Morbidelli: https://www.cambridge.org/core/books/perfusion-cell-culture-processes-for-biopharmaceuticals/5C650AD26D52B2435E7796D382ECE5DANext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com🧬 Stop second-guessing your CMC strategy before investor meetings. Our 1-Week CMC Assessment reveals your roadmap gaps and transforms uncertain founders into confident presenters who ace investor meetings. Secure your assessment at https://stan.store/SmartBiotech/p/get-cmc-clarity-in-1-week--investor-readySupport the show
Mar 21, 2024 • 17min
38: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 2
In part 2 of this insightful episode, we embark on a journey into the intricate world of biotech purification processes. Our guest, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into three key modalities, shedding light on the challenges and advancements in virus, RNA, and traditional vaccine purification.You will learn:Learn how to master the purification of virusesGet an overview of the advancements in RNA purification techniques: the evolution from simple RNA structures to long-stranded messenger RNA (mRNA)How to improve separation efficiency and simplify scale-up to meet increasing demandsTune in as we unravel the complexities of downstream processing and glean valuable insights to excel in the dynamic field of bioprocessing purification.Connect with Wei Zhang:LinkedIn: https://www.linkedin.com/in/wei-zhang-a6539845Next Step:Elevate your bioprocess development capabilities — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Mar 19, 2024 • 20min
37: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 1
In this episode, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into the complexities of purification. Wei’s team pioneers bioprocessing processes for diverse biotherapeutics.You will gain valuable insights into the intricate challenges and innovative solutions in bioprocessing purification.You will learn:Master scale-up challengesUnderstand how you can ensure product stabilityGet an overview of the advancements in purification techniquesThe conversation unravels the evolving landscape of bioprocessing, where the emergence of complex drug modalities necessitates continuous advancements in purification techniques and tools.Connect with Wei Zhang:LinkedIn: https://www.linkedin.com/in/wei-zhang-a6539845Next Step:Elevate your bioprocess development capabilities — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Mar 14, 2024 • 18min
36: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 2
Welcome back to the second part of our insightful interview with Joel Eichmann, Managing Director of Green Elephant Biotech.In this episode, we delve deeper into the technical aspects of adherent cell expansion systems, explore sustainable biotech practices, and discuss key considerations for cost-efficient and environmentally friendly bioprocessing.Key Insights:How to adopt a strategic approach to adherent cell culture developmentDelve into the intricacies of scaling up adherent cell culture, understanding the challenges associated with transitioning from T-flasks to larger, dynamic environmentsDiscover sustainable biotech practices to reducing your carbon footprintWhether you're a seasoned professional or a curious enthusiast, this episode provides a wealth of knowledge for those passionate about advancing biotech process develoment.Contact Joel Eichmann:LinkedIn: https://www.linkedin.com/in/joel-eichmannWebsite: https://www.greenelephantbiotech.comNext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
Mar 12, 2024 • 19min
35: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 1
Get ready for a deep dive into the world of bioprocess development as Joel Eichmann, Managing Director of Green Elephant Biotech, shares his expertise on smart strategies for adherent cell culture .Join us as we unravel the intricacies of adherent cell culture and discover the innovative strategies shaping the future of bioprocess development.You’ll get:Acquire a comprehensive understanding of the key challenges in developing an adherent cell culture process.Gain a fresh perspective on the role of microcarriers and explore alternative options for adherent cell cultures.Uncover the unique inspiration behind Joel's bioreactor for adherent cells and how childhood experiences can spark groundbreaking ideas.Join us for an insightful conversation and invaluable insights for biotech professionals, researchers, and enthusiasts like you looking to navigate the complexities of adherent cell culture and bioprocess development.Contact Joel Eichmann:LinkedIn: https://www.linkedin.com/in/joel-eichmannWebsite: https://www.greenelephantbiotech.comNext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show
