Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation
David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist
The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?There's a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver your groundbreaking therapy to clinics and market without delay, and still enjoy every single step.I'm David Brühlmann, a biotech entrepreneur and strategic advisor who partners with C-level biopharma leaders to tackle one of our industry's biggest challenges: reducing manufacturing costs to make lifesaving therapies accessible to more patients worldwide.Through engaging conversations with industry pioneers and practical insights from the trenches, this podcast tackles the critical challenges in bioprocess CMC development and manufacturing of recombinant proteins and cell and gene therapy products. We cut through the complexity so you can:Master bioprocess development with confidence and clarityExcel at scale-up and manufacturing of biologicsTransform your innovative therapy and manufacturing technology into market-ready solutions fasterOptimize manufacturing costs without compromising qualityMake data-driven decisions that reduce the risk of failureI can’t wait to help you do biotech the smart way.Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.Ready to transform your biomanufacturing journey? Let's dive in!Next Steps:Book a free call to reduce biomanufacturing costs and make lifesaving therapies more accessible: https://bruehlmann-consulting.com/call🧬 Ready to accelerate your IND timeline? Get the proven CMC Dashboard that's guided successful mAb programs from chaos to submission: https://stan.store/SmartBiotech/p/cmc-dashboard-for-biotech-foundersAccelerate biologics development with expert guidance: https://bruehlmann-consulting.comFor sponsorship opportunities, contact us at hello@bruehlmann-consulting.comVisit the Website: https://smartbiotechscientist.comEmail us: hello@bruehlmann-consulting.com
Episodes
Mentioned books
Jul 4, 2024 • 31min
68: How Process Mapping Transforms Knowledge Management in Biotech w/ Irwin Hirsh - Part 2
Join us as we explore the pivotal role of process mapping in biotech knowledge management. Our guest, Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, shares invaluable insights into leveraging technology to streamline operations.Key Insights:Identifying Critical Process Knowledge: Learn strategies to identify and manage vital process knowledge essential for optimal performance.Transitioning from Implicit to Explicit Knowledge: Discover why converting hidden, tribal wisdom into structured, accessible information is crucial for scalability and continuity.Harnessing Digital Tools: Explore effective approaches to digital transformation, ensuring seamless integration and collaboration across teams and time zones.Join us as Irwin uncovers actionable steps to enhance efficiency and innovation in biotech through strategic process mapping.Connect with Irwin Hirsh:LinkedIn: https://www.linkedin.com/in/ishirshQ-Specialists AB: https://www.qspecialists.comNext Steps:Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.com🧬 Stop second-guessing your CMC strategy. Get an investor-ready CMC roadmap in 2 weeks, before mistakes cost you $2M+ and 18 months of delays. Secure your spot at https://stan.store/SmartBiotech/p/dont-let-cmc-kill-your-funding-roundSupport the show
Jul 2, 2024 • 14min
67: How Process Mapping Transforms Knowledge Management in Biotech w/ Irwin Hirsh - Part 1
Want to turn your biotech chaos into streamlined success? Learn from expert Irwin Hirsh, a seasoned biotech consultant concentrating on enhancing business efficiency and effectiveness, on how process mapping can transform your knowledge management and elevate your business performance.Key Takeaways:Eliminate Scope Creep: Learn how to maintain focus in projects despite shifts and changes, improving productivity and reducing frustration.Bridge Experience Gaps: Understand how process mapping creates a common language, enabling seamless knowledge transfer between seasoned experts and newcomers.Enhance Systematic Approach: Discover the power of standardization and continuous improvement to boost overall business performance.Tune in to uncover practical strategies that can transform your knowledge management practices and drive your biotech endeavors to new heights.Connect with Irwin Hirsh:LinkedIn: https://www.linkedin.com/in/ishirshQ-Specialists AB: https://www.qspecialists.comNext Steps:Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.comSupport the show
Jun 27, 2024 • 16min
66: Freezing and Thawing Cells: the Science Behind Cryopreservation w/ Mark Davison - Part 2
Get ready to dive into the fascinating world of cryopreservation!In this episode, we welcome Mark Davison, an experienced entrepreneur and CEO of Grant Instruments, leaders in laboratory equipment, to explore the intricate science of freezing and thawing cells.Mark brings his wealth of experience to demystify this crucial process, revealing how cutting-edge technology ensures precision and reliability in preserving biological samples.Key Takeaways:Mastering Precision: Learn how data acquisition and controlled rate freezing are essential to maintaining the integrity of your samples.Technological Advancements: Discover the latest innovations transforming laboratory practices, from analog to digital conversions to remote monitoring.Entrepreneurial Insights: Gain valuable advice on leveraging support systems and cultivating a collaborative culture to succeed in scientific entrepreneurship.Tune in for an insightful conversation that blends technical expertise with practical advice, perfect for scientists and entrepreneurs alike!Connect with Mark Davison:LinkedIn: https://www.linkedin.com/in/markdavison100The Big Experiment podcast: https://thebigexperiment.buzzsprout.comGrant Instruments: https://www.grantinstruments.comNext Steps:Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.comSupport the show
Jun 25, 2024 • 26min
65: Freezing and Thawing Cells: the Science Behind Cryopreservation w/ Mark Davison - Part 1
Picture a world where we can freeze cells and bring them back to life perfectly intact.In this episode, we're joined by Mark Davison, a leading expert in cryopreservation and CEO of Grant Instruments to uncover the intricate science of freezing and thawing cells. From basic principles to advanced techniques, we delve into how cryopreservation is revolutionizing biotechnology and cell therapies.Key Takeaways:Cell Survival Secrets: Discover why water is both a friend and foe in preserving cell viability, and how precise control over freezing rates can prevent cell damage.Advanced Techniques: Learn about cutting-edge technologies that ensure safe and effective cryopreservation, minimizing risks associated with traditional methods like liquid nitrogen.Automation in Cryopreservation: Understand the future of lab workflows with automation, reducing human error and increasing reproducibility in cell-based experiments.Tune in to explore how cryopreservation is shaping the future of biotech!Connect with Mark Davison:LinkedIn: https://www.linkedin.com/in/markdavison100The Big Experiment podcast: https://thebigexperiment.buzzsprout.comGrant Instruments: https://www.grantinstruments.comNext Steps:Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.com🧬 Stop second-guessing your CMC strategy. Get an investor-ready CMC roadmap in 2 weeks, before mistakes cost you $2M+ and 18 months of delays. Secure your spot at https://stan.store/SmartBiotech/p/dont-let-cmc-kill-your-funding-roundSupport the show
Jun 20, 2024 • 22min
64: Why Sound Waves Are the Future of Gene Therapy Bioreactors w/ Gabriel Dumy - Part 2
Could sound waves be the revolutionary key to gene therapy manufacturing? In this episode, Gabriel Dumy, CTO and Co-founder at Kolibri, reveals how acoustic waves are set to transform cell harvesting and gene transfection processes, making biomanufacturing more efficient and less damaging to cells.Kolibri is a company revolutionizing the way we grow and engineer cells at scale using acoustic waves.Key Takeaways:Real-Time Cell Harvesting: Discover how reconfigurable acoustic waves enable non-damaging, precise cell harvesting without the need for harsh chemicals.Enhanced Gene Transfection: Learn about breakthrough methods to make cell membranes more permeable, dramatically improving the efficiency of gene delivery.Scalable Bioproduction: Understand the scalable potential of acoustic waves in bioreactors, offering innovative solutions for complex tissue engineering and fragile cell growth.Join us to explore how these advancements could revolutionize the future of gene therapy and beyond!Connect with Gabriel DumyLinkedIn: https://www.linkedin.com/in/gabrieldumyKolibri: https://www.kolibrilab.comNext Steps:Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.comSupport the show
Jun 18, 2024 • 27min
63: Why Sound Waves Are the Future of Gene Therapy Bioreactors w/ Gabriel Dumy - Part 1
Are sound waves the key to revolutionizing gene therapy? In this groundbreaking episode, we sit down with Gabriel Dumy, CTO and Co-founder at Kolibri, a company revolutionizing the way we grow and engineer cells at scale using acoustic waves.Gabriel shares the challenges facing modern bioproduction and unveils an exciting solution that's setting the stage for the future of gene therapy.Key Takeaways:Enhanced Cell Productivity: Discover how acoustic waves minimize shear stress, significantly boosting mammalian cell productivity and density.Versatile Bioreactor Design: Learn about a cell-agnostic technology that seamlessly adapts to various cell lines, simplifying process development.Scalable Innovation: Understand the potential of this scalable tech to maintain consistent microenvironments, paving the way for large-scale gene therapy production.Tune in to find out how acoustic waves could be the breakthrough gene therapy has been waiting for!Connect with Gabriel DumyLinkedIn: https://www.linkedin.com/in/gabrieldumyKolibri: https://www.kolibrilab.comNext Steps:Wondering how to develop biologics and cell & gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at https://bruehlmann-consulting.com🧬 Stop second-guessing your CMC strategy. Get an investor-ready CMC roadmap in 2 weeks, before mistakes cost you $2M+ and 18 months of delays. Secure your spot at https://stan.store/SmartBiotech/p/dont-let-cmc-kill-your-funding-roundSupport the show
Jun 13, 2024 • 15min
62: Magnetic Bead Technology: The New Era in Downstream Processing w/ Nils Brechmann - Part 2
Dive into the future of bioprocessing with Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, as we explore how magnetic bead technology is transforming downstream processing.MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals.Key Takeaways:Streamlined Purification: Discover how magnetic beads enable simultaneous clarification and capture, boosting efficiency.Cost Savings: Learn about significant cost reductions by integrating steps and improving process economics.Scalable Solutions: Understand the potential for large-scale applications, making magnetic bead technology a versatile option for biomanufacturing.Join us for an in-depth look at the benefits and innovations of magnetic bead technology in modern bioprocessing.Connect with Nils Brechmann:LinkedIn: https://www.linkedin.com/in/nils-brechmann-ph-d-44205114aMAGic BioProcessing: https://magicbioprocessing.comNext Step:Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentSupport the show
Jun 11, 2024 • 19min
61: Magnetic Bead Technology: The New Era in Downstream Processing w/ Nils Brechmann - Part 1
Dive into the latest episode as we explore how magnetic bead technology is revolutionizing downstream processing, promising higher yields and greater purity.Our guest, Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, shares his insights on overcoming industry challenges and the future of purification. MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals.Key Takeaways:Discover how magnetic beads integrate cell clarification and capture, reducing processing steps and mechanical stress.Learn about the remarkable efficiency of magnetic beads in achieving low Host Cell Protein (HCP) levels right from the start.Understand the economic benefits of this technology, from cost savings to increased throughput in large-scale facilities.Ready to elevate your bioprocessing game? Tune in now and harness the power of magnetic bead technology.Connect with Nils Brechmann:LinkedIn: https://www.linkedin.com/in/nils-brechmann-ph-d-44205114aMAGic BioProcessing: https://magicbioprocessing.comNext Step:Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentSupport the show
Jun 6, 2024 • 21min
60: Next-Generation Sequencing: Transforming Science and Medicine w/ Jonathon Hill - Part 2
Unlock the future of epigenetics and join us for an insightful conversation with Jonathon Hill as he delves into the groundbreaking world of next-generation sequencing (NGS) and its transformative impact on science and medicine. Jonathon Hill is the VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Biology and Physiology at Brigham Young University.Discover how cutting-edge nanopore technology is overcoming the limitations of traditional methods and revolutionizing epigenetic research.Key Takeaways:Unparalleled Accuracy: Learn how nanopore technology achieves 99.6% accuracy in methylation calls, eliminating PCR and bisulfite conversion noise.Comprehensive Insights: Understand the benefits of whole-molecule sequencing for detailed methylation analysis, providing a clearer, more precise picture of genetic data.Future of Diagnostics: Explore the future of NGS in clinical settings, with genomic and epigenetic data integration into electronic health records guiding personalized treatments.Don't miss this episode packed with innovative insights and the future landscape of genomic technology.Connect with Jonathon Hill:LinkedIn: https://www.linkedin.com/in/jonathon-t-hillWasatch BioLabs: https://www.wasatchbiolabs.comNext Steps:Schedule your free assessment to take process development to the next level now at https://bruehlmann-consulting.com/assessmentSupport the show
Jun 4, 2024 • 17min
59: Next-Generation Sequencing: Transforming Science and Medicine w/ Jonathon Hill - Part 1
Curious about the latest advancements in next-generation sequencing (NGS) and how they are revolutionizing science and medicine?In this episode, we delve into the cutting-edge developments of NGS with our expert guest, Jonathon Hill, VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Biology and Physiology at Brigham Young University, who has been at the forefront of this transformative field.Key Takeaways:Discover how NGS is empowering scientists to explore new frontiers in research with groundbreaking tools and technologies.Learn about the incredible advancements in long-read sequencing and their impact on genome assembly and understanding complex diseases.Understand how NGS is unlocking the potential of epigenetics, revolutionizing drug development, and enhancing diagnostic accuracy for personalized medicine.Join us to get an insider's view on how NGS is not only changing the landscape of research but also making a profound impact on human health. Don't miss this informative conversation with a leading expert in the field!Connect with Jonathon Hill:LinkedIn: https://www.linkedin.com/in/jonathon-t-hillWasatch BioLabs: https://www.wasatchbiolabs.comNext Steps:Schedule your free assessment to take process development to the next level now at https://bruehlmann-consulting.com/assessmentSupport the show
