Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.**TOP 10 LIFE SCIENCES PODCAST**Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?There's a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver your groundbreaking therapy to clinics and market without delay, and still enjoy every single step.I'm David Brühlmann, a biotech entrepreneur and strategic advisor who partners with C-level biopharma leaders to tackle one of our industry's biggest challenges: reducing manufacturing costs to make lifesaving therapies accessible to more patients worldwide.Through engaging conversations with industry pioneers and practical insights from the trenches, this podcast tackles the critical challenges in bioprocess CMC development and manufacturing of recombinant proteins and cell and gene therapy products. We cut through the complexity so you can:Master bioprocess development with confidence and clarityExcel at scale-up and manufacturing of biologicsTransform your innovative therapy and manufacturing technology into market-ready solutions fasterOptimize manufacturing costs without compromising qualityMake data-driven decisions that reduce the risk of failureI can’t wait to help you do biotech the smart way.Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.Ready to transform your biomanufacturing journey? Let's dive in!Next Steps:Book a free call to reduce biomanufacturing costs and make lifesaving therapies more accessible: https://bruehlmann-consulting.com/call🧬 Ready to accelerate your IND timeline? Get the proven CMC Dashboard that's guided successful mAb programs from chaos to submission: https://stan.store/SmartBiotech/p/cmc-dashboard-for-biotech-foundersAccelerate biologics development with expert guidance: https://bruehlmann-consulting.comFor sponsorship opportunities, contact us at hello@bruehlmann-consulting.comVisit the Website: https://smartbiotechscientist.comEmail us: hello@bruehlmann-consulting.com

Episodes

Mentioned books

Mar 26, 2024 • 26min

39: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 1

Explore perfusion processes and sustainability with our guest, Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science.Learn about the evolution of perfusion methodologies, its historical roots in addressing product stability, and its recent return to continuous and integrated manufacturing.Jochen discusses the economic and strategic reasons behind perfusion's resurgence, emphasizing the need for flexible, smaller-scale facilities.Key Learnings:Gain insight into the environmental impact of traditional facilities and the potential benefits of alternatives.Dive deep into the balance of cost, productivity, and sustainability in media consumption.Discover strategies for optimizing perfusion rates and sustainability.Get ready to expand your understanding of perfusion processes, sustainability, and the delicate dance between economics and environmental consciousness.Connect with Jochen Sieck:LinkedIn: https://www.linkedin.com/in/jochenbsieckACTIP Fellowship award: https://www.actip.org/fellowshipResources:Perfusion Cell Culture Processes for Biopharmaceuticals by Moritz Wolf, Jean-Marc Bielser, and Massimo Morbidelli: https://www.cambridge.org/core/books/perfusion-cell-culture-processes-for-biopharmaceuticals/5C650AD26D52B2435E7796D382ECE5DANext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com🧬 Stop second-guessing your CMC strategy. Get an investor-ready CMC roadmap in 2 weeks, before mistakes cost you $2M+ and 18 months of delays. Secure your spot here.Support the show

Mar 21, 2024 • 17min

38: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 2

In part 2 of this insightful episode, we embark on a journey into the intricate world of biotech purification processes. Our guest, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into three key modalities, shedding light on the challenges and advancements in virus, RNA, and traditional vaccine purification.You will learn:Learn how to master the purification of virusesGet an overview of the advancements in RNA purification techniques: the evolution from simple RNA structures to long-stranded messenger RNA (mRNA)How to improve separation efficiency and simplify scale-up to meet increasing demandsTune in as we unravel the complexities of downstream processing and glean valuable insights to excel in the dynamic field of bioprocessing purification.Connect with Wei Zhang:LinkedIn: https://www.linkedin.com/in/wei-zhang-a6539845Next Step:Elevate your bioprocess development capabilities — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show

Mar 19, 2024 • 20min

37: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 1

In this episode, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into the complexities of purification. Wei’s team pioneers bioprocessing processes for diverse biotherapeutics.You will gain valuable insights into the intricate challenges and innovative solutions in bioprocessing purification.You will learn:Master scale-up challengesUnderstand how you can ensure product stabilityGet an overview of the advancements in purification techniquesThe conversation unravels the evolving landscape of bioprocessing, where the emergence of complex drug modalities necessitates continuous advancements in purification techniques and tools.Connect with Wei Zhang:LinkedIn: https://www.linkedin.com/in/wei-zhang-a6539845Next Step:Elevate your bioprocess development capabilities — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show

Mar 14, 2024 • 18min

36: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 2

Welcome back to the second part of our insightful interview with Joel Eichmann, Managing Director of Green Elephant Biotech.In this episode, we delve deeper into the technical aspects of adherent cell expansion systems, explore sustainable biotech practices, and discuss key considerations for cost-efficient and environmentally friendly bioprocessing.Key Insights:How to adopt a strategic approach to adherent cell culture developmentDelve into the intricacies of scaling up adherent cell culture, understanding the challenges associated with transitioning from T-flasks to larger, dynamic environmentsDiscover sustainable biotech practices to reducing your carbon footprintWhether you're a seasoned professional or a curious enthusiast, this episode provides a wealth of knowledge for those passionate about advancing biotech process develoment.Contact Joel Eichmann:LinkedIn: https://www.linkedin.com/in/joel-eichmannWebsite: https://www.greenelephantbiotech.comNext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show

Mar 12, 2024 • 19min

35: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 1

Get ready for a deep dive into the world of bioprocess development as Joel Eichmann, Managing Director of Green Elephant Biotech, shares his expertise on smart strategies for adherent cell culture .Join us as we unravel the intricacies of adherent cell culture and discover the innovative strategies shaping the future of bioprocess development.You’ll get:Acquire a comprehensive understanding of the key challenges in developing an adherent cell culture process.Gain a fresh perspective on the role of microcarriers and explore alternative options for adherent cell cultures.Uncover the unique inspiration behind Joel's bioreactor for adherent cells and how childhood experiences can spark groundbreaking ideas.Join us for an insightful conversation and invaluable insights for biotech professionals, researchers, and enthusiasts like you looking to navigate the complexities of adherent cell culture and bioprocess development.Contact Joel Eichmann:LinkedIn: https://www.linkedin.com/in/joel-eichmannWebsite: https://www.greenelephantbiotech.comNext Step:Elevate your biologics development strategy — Schedule your free assessment now: https://bruehlmann-consulting.comSupport the show

Mar 7, 2024 • 11min

30: From Monoclonals to Gene Therapy: Tips for Biopharma Process Development w/ Neil Templeton - Part 2

In our insightful second part of the conversation, we broaden our perspective to delve into the various modalities within the biotech industry, highlighting the unique and shared aspects of process development and scale-up.Neil Templeton, the Director of Upstream Process Development at Solid Biosciences, passionately articulates his commitment towards making gene therapy more accessible. He does this by outlining strategic solutions to reduce the costs of development and manufacturing.You will gain:A comprehensive understanding of process development's similarities and differences across biologics, vaccines, and cell and gene therapy manufacturing.Effective strategies aimed at reducing the costs associated with gene therapy development and manufacturing.Insights into how capitalizing on the expertise from the biologics sector can positively impact other fields.To connect with Neil Templeton and learn more about his work, visit his LinkedIn profile.LinkedIn: https://www.linkedin.com/in/neil-templetonNext Step:Elevate your bioprocess development strategy — Grab your free assessment now: https://bruehlmann-consulting.comSupport the show

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