Fat Science

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down the essentials of a true metabolic workup. This episode moves beyond social media diet trends and digs into the science behind comprehensive lab panels, what they measure, and why they matter for your whole-body health. Dr. Cooper explains how to interpret common and advanced metabolic markers—like blood sugar, insulin, cholesterol, hormone levels, and more—while Andrea and Mark share personal insights into the power of understanding your metabolic baseline. If you’re concerned about weight, diabetes, or just want to know your numbers, this episode gives you the knowledge to talk confidently with your healthcare provider.Key Takeaways:A whole-body metabolic approach goes beyond just weight or blood pressure—comprehensive lab work (plus family history) is essential to uncover risks or dysfunction early.Standard blood panels provide useful clues (glucose, cholesterol, liver, kidney, blood pressure), but advanced tests (A1C, lipid particles, hormone levels, inflammation markers) round out the picture.Metabolic dysfunction is driven by factors far deeper than calories in/out—dieting and under-fueling can actually weaken metabolism over time.Medication for metabolic health is not a failure; it’s a science-backed intervention. Early and accurate testing allows for better, evidence-based treatment.Don’t ignore “borderline” results—addressing issues early is easier and more effective than trying to reverse advanced dysfunction later.Personal Stories & Practical Advice:Andrea recounts her life-changing journey from endless dieting to real answers through complete metabolic testing and individualized treatment.Mark highlights the need for patients to advocate for themselves and ask for more than just the standard panel at annual exams.References:Diet Failure Rate• Mann, T., et al. (2007). "Medicare's search for effective obesity treatments: diets are not the answer." American Psychologist, 62(3), 220-233• Anderson, J. W., et al. (2001). "Long-term weight-loss maintenance: a meta-analysis of US studies." American Journal of Clinical Nutrition, 74(5), 579-584Persistent Metabolic Adaptation• Fothergill, E., et al. (2016). "Persistent metabolic adaptation 6 years after 'The Biggest Loser' competition." Obesity, 24(8), 1612-1619• Rosenbaum, M., & Leibel, R. L. (2010). "Adaptive thermogenesis in humans." International Journal of Obesity, 34(S1), S47-S55Long-Term Hormonal Disruption • Sumithran, P., et al. (2011). "Long-term persistence of hormonal adaptations to weight loss." New England Journal of Medicine, 365(17), 1597-1604• Rosenbaum, M., et al. (2005). "Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight." Journal of Clinical Investigation, 115, 3579-3586Weight Cycling Cardiovascular Risks• Montani, J. P., et al. (2006). "Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory." International Journal of Obesity, 30(S4), S58-S66Resources:Connect with Dr. Emily Cooper on LinkedInConnect with Mark Wright on LinkedInConnect with Andrea Taylor on InstagramFat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.comScience is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright uncover the truth about fatty liver disease and its rapid rise in both adults and children. It’s estimated 125 million Americans have the disease. Dr. Cooper explains the critical role the liver plays in metabolism—covering hundreds of essential functions—and why fatty infiltration poses serious risks. The episode demystifies diagnosis, risk factors, and treatment options, empowering listeners to take a proactive approach to liver health and metabolic wellness.Key Takeaways:Fatty liver disease, now known as MASLD—Metabolic Dysfunction-Associated Steatotic Liver Disease, affects about 30% of adults, and is rising in youth, especially those with obesity or type-2 diabetes.Risk is not limited to higher body weights; up to 15% of normal-weight people are also affected, with genetics playing a significant role.Diagnosis can be tricky: blood enzymes (ALT, AST) and platelet counts factor into the highly predictive FIB-4 score, while imaging (like fibroscan) provides clarity on severity.Untreated, fatty liver can progress to inflammation, fibrosis, and even require a liver transplant, though early-stage disease is often reversible with proper intervention.Treatment focuses on improving metabolic function—through medication, diabetes management, and sometimes lifestyle changes—as solely relying on diet and exercise may not be enough, particularly for advanced cases.Personal Stories & Practical Advice:Andrea shares her own experience discovering fatty liver disease and seeing rapid improvement after metabolic treatment.The hosts discuss common misconceptions, and why liver health should be checked in both children and adults, regardless of body size or outward health.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the concept of “male menopause” and whether it’s backed by science. Dr. Cooper breaks down hormonal changes in men, including testosterone decline, metabolic dysfunction, and the myths surrounding andropause. The episode dives into why men and women experience aging differently, how metabolism ties into hormone shifts, and what really happens to male fertility and energy over time. After listening, you’ll understand why “male menopause” isn’t the full story and what really matters for men’s health as they age.Key Takeaways:There’s no sudden “male menopause”—testosterone declines gradually in men, unlike the rapid hormonal changes seen in female menopause.Metabolic dysfunction can suppress testosterone in men, leading to fatigue, muscle loss, and changes in body fat distribution.Converting testosterone to estrogen in belly fat can further suppress testosterone, creating a cycle that impacts energy and mood.Testosterone therapy might be beneficial for some men with low levels, but should always be guided by a healthcare provider after thorough evaluation.Most supplements marketed to “boost testosterone” are unproven and potentially unsafe—focus on medical advice and proper testing.Personal Stories & Practical Advice:Mark shares his journey with testosterone treatment and how restoring balance improved his mood and energy.Andrea and Dr. Cooper discuss the importance of understanding individual lab results, getting the full metabolic picture, and consulting with primary care providers before considering hormone therapy.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore the expanding world of telehealth in treating metabolic issues. Dr. Cooper sheds light on both the promise and pitfalls of accessing medications like GLP-1s through online platforms. The episode dives into the effectiveness of patient-provider relationships, the importance of comprehensive and personalized care, and the potential red flags in impersonal telehealth services. After listening, you’ll understand the benefits of telehealth and why thoughtful, thorough medical guidance is crucial for metabolic health.Key Takeaways:Telehealth has improved accessibility and convenience for metabolic care, but not all platforms offer the same quality of support.The lack of personalized interaction and lab-based assessments in many telehealth services can pose risks to patient health.Quick, transactional telehealth models often prioritize medication sales over holistic care and ongoing patient monitoring.Comprehensive care requires detailed history-taking, follow-up, and lab work—elements often missing in mass-market telehealth.Listeners should watch for red flags such as no direct provider interaction, absence of lab testing, and subscription models tied to product sales.Personal Stories & Practical Advice:Andrea reflects on her own journey and the difference a dedicated, whole-person approach made to her health.Dr. Cooper shares her experience testing a mass-market telehealth site, exposing the superficial nature of some programs.The panel urges listeners to seek out board-certified providers and reputable telehealth organizations for genuine care.Link to US National telehealth clinics with Board Certified Obesity Medicine providers: Knownwell (non-affiliated)Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org ordr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This conversation dives into the myths of 'starvation mode,' with insights into how dieting affects metabolism. Weight loss plateaus are clarified, revealing natural body adaptations. The connection between metabolic health and cognition is highlighted, as well as the complex metabolic effects of cannabis. Liposuction's potential for rapid fat regain is discussed, especially for individuals with low leptin levels. Finally, the podcast reviews the evolving landscape of GLP-1 medications, including affordability and upcoming therapeutic options.

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright explore why metabolic health transformations require time, persistence, and a holistic approach. Andrea shares her 14-year journey with Dr. Cooper, highlighting the slow, individualized nature of healing a dysfunctional metabolism and why quick fixes rarely work. Dr. Cooper explains how complex feedback loops, hormonal adaptations, and life events can slow progress—and why health markers, not just the number on the scale, are crucial measures of success. The conversation encourages patience, self-compassion, and a focus on sustainable health, not just rapid weight loss.Key Takeaways:Healing metabolic dysfunction is a complex, highly individualized process that often takes years—not weeks or months.Dieting, stress, disrupted sleep, and misguided exercise can send the body into "famine mode," making weight loss even harder.Metrics like blood pressure, cholesterol, and glucose often improve before significant weight loss occurs—these health gains matter.Medications and bariatric surgery can help in stubborn cases, but long-term success depends on a combination of medical, lifestyle, and psychological support.As many as 20% of patients may be "non-responders" to current treatments, highlighting the need for ongoing metabolic research and new therapies.Personal Stories & Practical Advice:Andrea details her long road—from early GLP-1 medications and plateaus to bariatric surgery and ongoing adjustments—with the emphasis that patience paid off.Dr. Cooper and Mark reinforce the importance of redefining food as fuel and joy, not the enemy, and letting go of blame or unrealistic expectations tied to the scale.The episode highlights small wins, the value of routine lab work, and celebrating all forms of progress—especially the non-scale victories.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This discussion explores the intriguing world of GLP-1 medications like Ozempic and Wegovy. Experts dive into their evolution, improved dosing methods, and how they effectively promote weight loss. Individual health factors play a crucial role in whether one can taper off these medications. Notably, it's highlighted that body composition and metabolic markers are essential for treatment assessments. Future therapies may even incorporate multi-hormone approaches, enhancing metabolic health beyond current options.

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unpack the complexities of dosing GLP-1 medications for metabolic health and weight management. Dr. Cooper emphasizes the importance of an individualized approach, debunking the myth that higher doses or faster titration always lead to better outcomes. The team addresses listener questions about how and when to increase doses, highlight the risks of rapid escalation, and discuss the nuanced ways these drugs impact metabolic health beyond just weight loss. Real-life experiences and thoughtful, science-backed guidance will help you navigate your own journey with metabolic dysfunction and medication.Key Takeaways:Dosing of GLP-1 medications should always be tailored to the individual, considering response, side effects, and other health factors—not just the speed of weight loss.Starting at the lowest dose and titrating slowly increases medication tolerance and long-term effectiveness.Lab markers such as A1C, glucose, cholesterol, and muscle mass are key indicators in determining if the medication and dosing are "working."Rapidly escalating to the highest dose can backfire, causing side effects and limiting future treatment options.Dieting mindsets and using medication solely as an appetite suppressant can lead to loss of lean mass and suboptimal health outcomes.Ongoing patient-provider relationships and regular lab work ensure medication strategies remain safe and effective.Personal Stories & Practical Advice:Andrea reflects on her initial desire for quick fixes and shares lessons learned about patience, nourishment, and long-term progress. Mark discusses insurance-driven medication switches and finding the “sweet spot” for dosing with Dr. Cooper’s guidance.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science for a special mailbag episode answering listener questions about metabolic health. Dr. Cooper explains the difference between mindful and mechanical (timed) eating, especially for those using medications like Zepbound. The team also addresses emotional challenges tied to frequent eating, societal fat shaming, and the complexities of medication side effects for those on GLP-1 agonists and antipsychotics. Real experiences and practical advice help shed light on fueling your body, breaking free from diet culture guilt, and navigating complex emotions on the journey to better health.Key Takeaways:GLP-1 medications like Zepbound affect appetite and metabolism but can also suppress hunger cues; mechanical eating—timing meals and including all food groups—prevents nutritional deficits and supports long-term metabolic health.Eating too few calories, even when appetite is low, can be detrimental; mechanical eating helps maintain muscle mass and prevent stalled metabolism.Emotional barriers, guilt, and anxiety around food are common due to fat shaming and past dieting experiences. Meal planning and support from dietitians can help ease this transition.GLP-1s may alter medication absorption or trigger anxiety episodes due to blood sugar fluctuations; monitoring and professional advice are recommended when combining with psych meds.Personal Stories & Practical Advice:Andrea shares strategies for getting enough nutrition when appetite is low, her experiences with fat shaming, and her approach to enjoying food without guilt.Mark and Dr. Cooper discuss breaking free from restrictive food mindsets and building a positive, fuel-focused relationship with eating.Key Takeaways:Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright tackle the urgent issue of deep funding cuts to scientific research in the United States. Dr. Cooper shares firsthand insight on how these changes are affecting patient care and scientific integrity, highlighting the pressures researchers face—including censorship and loss of resources at institutions like the NIH. The conversation sheds light on how misinformation, government interference, and reduced diversity in studies threaten the future of metabolic, cancer and public health research. Listeners will better understand why research matters for everyday health, and what’s at stake when critical projects lose funding.Key Takeaways:Sweeping research cuts at major institutions like NIH jeopardize progress in areas like metabolic health, cancer, ALS, heart disease, and Alzheimer’s.Researchers are facing censorship and pressure to alter or suppress scientific findings in nutrition, autism, and vaccine research.Reducing diversity in research undermines scientific accuracy and inclusivity, risking treatments that don’t address the needs of all populations.Slashed funding will stall new medical discoveries, limit future treatment options, and may have consequences for decades to come.Misinformation around vaccines and public health is rising as government agencies are pressured to alter or hide true scientific data.Resources:Links: Current Medical ReportingVin Gupta, MD Nutrition InformationNutrition for Mortals Podcast with Dietitians: Matt and Jen Infectious Diseases, ImmunizationsMaria Van Kerkhove - WHOJeff DuchinMichael Osterholm, CIDRAP Kevin Hall ResearchKevin Hall on LinkedIn Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us atinfo@diabesityinstitute.org.Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/