Fat Science

Mailbag: Metabolism Myths, Plateaus, and More

Jun 2, 2025
This conversation dives into the myths of 'starvation mode,' with insights into how dieting affects metabolism. Weight loss plateaus are clarified, revealing natural body adaptations. The connection between metabolic health and cognition is highlighted, as well as the complex metabolic effects of cannabis. Liposuction's potential for rapid fat regain is discussed, especially for individuals with low leptin levels. Finally, the podcast reviews the evolving landscape of GLP-1 medications, including affordability and upcoming therapeutic options.
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INSIGHT

Metabolism Slows, Not Stops

  • Metabolism naturally slows during calorie deprivation as a survival mechanism, termed biological adaptation. - This slowing explains why prolonged diets often stall and why metabolism doesn't stop weight loss entirely.
ADVICE

Assess Plateaus Correctly

  • Understand weight plateaus by looking at prior weight trends and lifestyle habits first. - Use weight loss rate calculations over time to distinguish true plateaus from normal metabolic adjustments.
INSIGHT

Metabolic Health and Brain

  • Metabolic health critically impacts brain function, mood disorders, and risk for dementia. - Alzheimer's is linked to poor brain glucose metabolism, earning it the nickname 'type 3 diabetes'.
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