

Your Brain On
Drs. Ayesha and Dean Sherzai
A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life's everyday health questions and learn the essentials of brain health and optimization, one topic at a time.
Episodes
Mentioned books

Oct 29, 2025 • 42min
Your Brain On... Nutrition (with Dr. Walter Willett)
 Everyone eats. It's the one thing we all have in common. And yet, nutrition has become one of the most confusing, divisive, and misunderstood sciences in modern life. Low-fat. High-fat. Keto. Vegan. Paleo. Superfoods. For every study, there's a headline that seems to say the opposite. In this episode, we turn to one of the most trusted voices in nutrition research to cut through the noise: Dr. Walter Willett, MD, DrPH. Dr. Willett, Professor of Epidemiology and Nutrition at Harvard T.H. Chan School of Public Health, has spent more than four decades studying how what we eat affects our health, longevity, and brain function. His work has helped reshape dietary guidelines around the world, replacing fear and fads with clarity and evidence. Together, we unpack what the science really says about diet and the brain: how food choices shape inflammation, cognition, and long-term disease risk, and what practical lessons decades of data can teach us about eating for life and longevity. In this conversation, we discuss: • How nutrition became so confusing (and what the data actually shows) • Why the quality of fat matters more than the amount • How refined carbohydrates fuel inflammation, insulin resistance, and brain fog • The power of fiber and the microbiome for mood and memory • Why plant-based proteins come out ahead for health and sustainability • How global dietary guidelines are changing (and what's still misunderstood) • The intersection of nutrition, planetary health, and human wellbeing Dr. Walter Willett has authored over 2,000 scientific papers and several landmark books, including 'Eat, Drink, and Be Healthy'. This is... Your Brain On Nutrition. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/  'Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. 'Your Brain On... Nutrition' • SEASON 6 • EPISODE 2 LINKS Dr. Walter Willett at Harvard T.H. Chan School of Public Health: https://hsph.harvard.edu/profile/walter-c-willett/   Dr. Willett's book, 'Eat, Drink, and Be Healthy':  https://www.goodreads.com/book/show/5579.Eat_Drink_and_Be_Healthy  FOLLOW US Join NEURO World: https://neuro.world/   Instagram: https://www.instagram.com/thebraindocs  YouTube: https://youtube.com/thebraindocs  Website: https://thebraindocs.com/  

Oct 22, 2025 • 1h 53min
Your Brain On... Autism
 In this engaging discussion, Dr. Ami Klin, director at the Marcus Autism Center, shares groundbreaking insights on detecting autism as early as infancy. Dr. Joseph Buxbaum from the Seaver Autism Center reveals the strong genetic links to autism and the implications for future therapies. Dr. Andrea Love tackles persistent vaccine myths, emphasizing the importance of trust in conversations with concerned parents. Together, they explore the evolution of autism definitions, the rise of profound autism, and the critical role of debunking misinformation in transforming lives. 

Jul 23, 2025 • 1h 54min
Your Brain On... Diabetes
 Brenda Davis, a registered dietitian and plant-based nutrition expert, alongside Michelle McMacken, a public health leader, and Dr. Theodore Friedman, an internal medicine professor, delve into the multifaceted nature of diabetes. They discuss its impacts on brain health and cognitive function, debunk myths about carbohydrate intake, and emphasize the power of personalized nutrition. The trio advocates for compassionate care, the necessity of community support, and the importance of lifestyle changes, aiming to empower individuals in managing and reversing diabetes. 

20 snips
Jul 9, 2025 • 50min
Your Brain On... Alzheimer's (Mythbusting Special)
 This engaging discussion tackles persistent myths about Alzheimer’s, including the misconception that it's simply a part of aging. It highlights the influence of genetics and lifestyle on the disease's onset, pointing to the power of early detection. The hosts debunk popular dietary myths surrounding supplements and emphasize the significance of holistic health practices. Listeners gain valuable tips for maintaining cognitive vitality, such as the importance of social connections and fiber-rich foods, alongside insights on lifelong learning and personal growth. 

Jun 25, 2025 • 34min
Your Brain On... Purpose (Sherzai Family Special)
 With big changes happening in the Sherzai family household, we sat down for a roundtable discussion about the concept that will shape what we're all doing next: our purpose. In this 'unplugged' mid-season chat, we're joined by our kids — Sophia and Alex! — for a wide-ranging conversation about our values and goals. How they form, how they falter, and how they evolve, in an increasingly noisy world. Together, we discuss: • The neurological and evolutionary importance of purpose • How a firm sense of purpose can help us develop better habits • The difference between 'internal' and 'external' purpose • How we can stay focused on our values in the face of modern life's distractions • The promises and pitfalls of AI in shaping (and potentially hijacking) our sense of purpose Sophia — now heading off to Boston! — works in biomedical engineering and brain-computer interfaces. And Alex (self-proclaimed Tetris champion) is focused on the intersection of brain health and artificial intelligence. This is Your Brain On... Purpose, a Sherzai Family Special! 

13 snips
Jun 18, 2025 • 50min
Your Brain On... Creatine
 Matthew K. Taylor, a lead researcher on creatine's role in Alzheimer's, and Russell Swerdlow, an expert in brain energy metabolism, discuss the promising but nuanced findings of recent studies on creatine supplementation. They highlight the critical distinction between hype and hope, examining how scientific nuances can easily be lost in the health discourse. The duo emphasizes the need for rigorous research on creatine's effects, particularly regarding dosage and cognitive health, while promoting holistic lifestyle changes for optimal brain function. 

19 snips
Jun 12, 2025 • 57min
Your Brain On... Stress
 Join Dr. Sharon Bergquist, a Yale- and Harvard-trained physician, and Dr. Mithu Storoni, a neuroscientist and author, as they explore the surprising perks of stress. They discuss the difference between 'good' stress that can enhance brain function and 'bad' stress that harms it. Practical strategies for harnessing stress as a tool for resilience are shared, along with insights on how moderate stress may even slow aging. Discover how to reframe stress for personal growth and cognitive health! 

23 snips
May 29, 2025 • 1h 5min
Your Brain On... Stroke
 Dr. Olajide Williams, a neurologist and vice dean at Columbia University, shares his expertise on stroke prevention. He emphasizes that up to 90% of strokes could be prevented with awareness and education. The discussion includes how to quickly recognize a stroke using the ‘act FAST’ acronym, and the importance of blood pressure management. Dr. Williams highlights his Hip Hop Public Health initiative, which teaches kids to save lives, and addresses healthcare disparities, stressing that lifestyle changes are key in stroke prevention. 

11 snips
May 22, 2025 • 28min
Your Brain On... The Food Industry
 Marion Nestle, a renowned authority on food policy and Emerita Professor at NYU, sheds light on the challenges posed by the food industry in making healthier choices. She discusses how food marketing exploits our psychology and why willpower alone isn't enough. Marion emphasizes the significance of community initiatives, schools, and policy in shaping nutritional habits. She also highlights the detrimental effects of stress and decision fatigue on our diets, and the double-edged role of social media in spreading nutrition information. 

May 15, 2025 • 50min
Your Brain On... Lyme Disease
 John Aucott, Director of the Johns Hopkins Lyme Disease Clinical Research Center, and Richard Marconi, a microbiology professor at VCU, shed light on the complex landscape of Lyme disease. They discuss lingering symptoms post-treatment and Lyme's neurological challenges. The conversation reveals how climate change and social disparities amplify tick-borne illnesses. They also explore the pitfalls of alternative medicine targeting vulnerable patients and the future of Lyme vaccines, making the case for improved trust in healthcare through empathy and transparency. 


