Your Brain On

In this conversation, Lisa Mosconi, Director of the Women's Brain Initiative and author of 'The Menopause Brain', teams up with Maria Shriver, founder of the Women’s Alzheimer’s Movement. They delve into the higher Alzheimer’s risks faced by women and how menopause accelerates brain aging. The duo discusses estrogen’s protective role, the truth about hormone replacement therapy, and the impact of genetics like APOE4. They emphasize lifestyle changes—including stress management and cognitive engagement—to mitigate neurological changes during menopause.

Dr. Ani Patel, a cognitive psychologist, Dr. Charles Limb, a surgeon and musician, and Jonathan Biss, a renowned pianist and author, dive into the captivating connection between music and the brain. They discuss how music enhances cognitive functions and emotional well-being. From therapeutic uses in Alzheimer's patients to the impact of rhythm on language recovery, their insights reveal music's powerful role in fostering communication and learning. The trio also explores music's cultural significance and how creativity intertwines with neurological processes.

Dr. Adrian Chavez, a nutrition researcher with a PhD in Nutrition and Health Promotion, dives into the booming supplement industry. He reveals the shocking lack of evidence behind many popular claims, urging listeners to distinguish between genuine effects and placebo. Topics like omega-3s and the impact of ashwagandha on brain health are explored, alongside the psychology driving our supplement choices. With tips on navigating misleading marketing, this conversation empowers listeners to make informed decisions about their wellness.

Dr. David Brody, a leading neurologist specializing in traumatic brain injuries, dives into the real-world impacts of TBIs. He discusses how these injuries occur, from mild concussions to severe trauma, and their links to neurodegenerative diseases. The conversation highlights the prevalence of TBIs in athletes and military personnel, emphasizing the need for improved protective gear. Brody also shares insights on preventative lifestyle habits and new diagnostic techniques that could revolutionize treatment and recovery for those affected.

In this discussion, Richard Bazinet, a University of Toronto professor researching brain lipid metabolism, and Bill Harris, an omega-3 expert behind the Omega-3 Index, share insights on the significance of omega-3 fatty acids for brain health. They unpack the differences between omega-3 and omega-6, revealing how dietary sources are crucial since our bodies can’t produce these essential fats. The conversation also explores the risks of low intake and the importance of DHA at every life stage, while advocating for more comprehensive research on omega-3 benefits and metabolism.

Larry Rosen, a research psychologist specializing in tech's psychological impact, and Jean Twenge, an author known for her insights into youth mental health, dive into the social media landscape. They discuss the alarming effects of social media on brain health, addiction, and mental wellbeing, particularly for teens. Their conversation highlights the neurological tricks used by apps that keep users scrolling and offers practical strategies to foster a healthier digital relationship. Plus, they explore issues like doom-scrolling and the pervasive impact of headlines on sleep and anxiety.

Sophia Sherzai, a biomedical engineer, and Alex Sherzai, an AI specialist, join their neuroscientist parents for a festive discussion. They delve into life as a family of brain experts, share their ambitions for 2025, and navigate the complexities of holiday dynamics. Topics like the importance of emotional health, personal growth, and overcoming misconceptions about dopamine addiction take center stage. With humor and insights, they also reflect on cherished memories and the power of connection over consumerism during the holidays.

Matthew Taylor, a registered dietitian specializing in ketogenic diets, and Russell Swerdlow, a neurology professor focused on Alzheimer's research, delve into the intriguing world of ketogenic diets and brain health. They discuss the historical origins of the diet and its modern-day implications for cognitive function. Key insights include how ketogenic diets can serve as an alternative energy source for the brain, their potential benefits for Alzheimer's patients, and the impact of diet versus supplements on cognitive performance.

Ammar Al-Chalabi and Merit Cudkowicz, leading experts in ALS research, delve into the complexities of amyotrophic lateral sclerosis. They discuss how ALS impacts the body and brain, highlighting genetic predispositions and emerging environmental risks. The duo explores breakthroughs in gene therapy that may reverse the disease's effects, alongside the role of lifestyle and multidisciplinary care in patient management. They also reflect on the Ice Bucket Challenge's transformative impact on ALS awareness and funding.

In this discussion, Dr. John Krystal, a Yale Psychiatry and Neuroscience Professor, and Dr. Gerard Sanacora, Director of the Yale Depression Research Program, dive into ketamine’s evolution from anesthetic to mental health treatment. They unveil its rapid antidepressant effects, mechanisms influencing neuroplasticity, and potential to combat neurodegenerative diseases. The conversation also highlights risks, individual response variability, and the critical need for careful dosing and monitoring in therapeutic settings.