
Your Brain On
A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life’s everyday health questions and learn the essentials of brain health and optimization, one topic at a time.
Latest episodes

Jan 15, 2025 • 49min
Your Brain On... Social Media
Larry Rosen, a research psychologist specializing in tech's psychological impact, and Jean Twenge, an author known for her insights into youth mental health, dive into the social media landscape. They discuss the alarming effects of social media on brain health, addiction, and mental wellbeing, particularly for teens. Their conversation highlights the neurological tricks used by apps that keep users scrolling and offers practical strategies to foster a healthier digital relationship. Plus, they explore issues like doom-scrolling and the pervasive impact of headlines on sleep and anxiety.

4 snips
Dec 25, 2024 • 51min
Your Brain On... (Sherzai Family Holiday Special)
Sophia Sherzai, a biomedical engineer, and Alex Sherzai, an AI specialist, join their neuroscientist parents for a festive discussion. They delve into life as a family of brain experts, share their ambitions for 2025, and navigate the complexities of holiday dynamics. Topics like the importance of emotional health, personal growth, and overcoming misconceptions about dopamine addiction take center stage. With humor and insights, they also reflect on cherished memories and the power of connection over consumerism during the holidays.

Dec 18, 2024 • 50min
Your Brain On... Ketogenic Diets
Matthew Taylor, a registered dietitian specializing in ketogenic diets, and Russell Swerdlow, a neurology professor focused on Alzheimer's research, delve into the intriguing world of ketogenic diets and brain health. They discuss the historical origins of the diet and its modern-day implications for cognitive function. Key insights include how ketogenic diets can serve as an alternative energy source for the brain, their potential benefits for Alzheimer's patients, and the impact of diet versus supplements on cognitive performance.

6 snips
Dec 11, 2024 • 47min
Your Brain On... ALS
Ammar Al-Chalabi and Merit Cudkowicz, leading experts in ALS research, delve into the complexities of amyotrophic lateral sclerosis. They discuss how ALS impacts the body and brain, highlighting genetic predispositions and emerging environmental risks. The duo explores breakthroughs in gene therapy that may reverse the disease's effects, alongside the role of lifestyle and multidisciplinary care in patient management. They also reflect on the Ice Bucket Challenge's transformative impact on ALS awareness and funding.

8 snips
Dec 4, 2024 • 45min
Your Brain On... Ketamine
In this discussion, Dr. John Krystal, a Yale Psychiatry and Neuroscience Professor, and Dr. Gerard Sanacora, Director of the Yale Depression Research Program, dive into ketamine’s evolution from anesthetic to mental health treatment. They unveil its rapid antidepressant effects, mechanisms influencing neuroplasticity, and potential to combat neurodegenerative diseases. The conversation also highlights risks, individual response variability, and the critical need for careful dosing and monitoring in therapeutic settings.

9 snips
Nov 20, 2024 • 1h 9min
Your Brain On... Sex
In this lively discussion, guests Nicole Prause, a UCLA sexual behavior expert, and Rena Malik, a urogynecologist focused on women's sexual health, dive into the fascinating neurological processes behind attraction and desire. They tackle how age and significant life changes like menopause affect sexual desire. The complex debate around pornography and its impact on intimate relationships is explored. They also emphasize the importance of nutrition, exercise, and debunk myths associated with women’s sexual health, promoting open conversations free from stigma.

7 snips
Oct 17, 2024 • 57min
Your Brain On... Protein
In this engaging discussion, nutrition scientists Matthew Nagra and Alan Flanagan delve into the complex world of protein. They dissect the health benefits of protein for both body and brain, emphasizing its necessity as we age. The conversation explores the merits of plant-based versus meat protein, along with the potential pitfall of over-reliance on protein supplements. Nagra and Flanagan clarify how much protein we actually need and share tips on incorporating quality protein sources into our diets, challenging popular myths along the way.

20 snips
Oct 9, 2024 • 1h 5min
Your Brain On... Misinformation
In this enlightening discussion, guests include David L. Katz, a leader in preventive medicine, and Steven Novella, a clinical neurologist and skeptic. They tackle the deluge of misinformation flooding social media, emphasizing the crucial need for critical thinking in navigating health advice. Jonathan Stea shares insights on the psychological impacts of health decisions, while Idrees Mughal, a misinformation debunker, highlights the importance of scientific literacy. Together, they explore strategies for effective science communication and educational reform to combat pseudoscience.

5 snips
Oct 2, 2024 • 1h 5min
Your Brain On: A Brain Health Revolution Summit Special
20 incredible conversations with leading scientists, in one hour. We’re excited to present this special installment of Your Brain On, featuring highlights from some of the speakers talking at our first ever Brain Health Revolution Summit. Our first summit, running September 30 through October 6 2024, features seven days of hour-long discussions with the scientists who are actually conducting the studies, publishing the papers, and pushing public health policy reforms that are shaping our world. No matter when you’re listening to this episode, visit https://bhrsummit.com/ for more information about the summit — be it our first 2024 edition, or a future installment! Day 1: The Brain Health Landscape: From Insights to Action Day 2: Mental Health Matters and Heart Health for a Stronger Brain Day 3: Women’s Brain Health: Hormones, Longevity, and Vitality Day 4: Emerging Challenges in Brain Health Day 5: Fuel for Thought: Nutrition, the Gut, and the Brain Day 6: Move, Breathe, Thrive: Exercise and Stress Management Day 7: Recharge and Optimize: Sleep and Cognitive Performance This special episode includes excerpts of our conversations with: Rachel Dolhun, MD Michael Okun, MD Charles DeCarli, MD Ari Tuckman, PsyD Amishi Jha, PhD Danielle Belardo, MD Margarett McCarthy, PhD Lisa Mosconi, PhD Lisa Genova Idrees ‘Dr. Idz’ Mughal, MBBS, MRes, DipIBLM Daniele Piomelli, PhD Frank Lin, MD, PhD Alan Flanagan, PhD Matthew Nagra, ND Stuart Phillips, PhD Natali Edmonds, PhD Satchin Panda, PhD Donn Posner, MD Sujay Kansagra, MD Yaakov Stern, PhD For more information about the Brain Health Revolution Summit, visit: https://bhrsummit.com/ The Brain Health Revolution Summit 2024 is presented in partnership with Healthy Minds Initiative: thymindsinitiative.org ‘Your Brain On’ is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai.

Sep 25, 2024 • 56min
Your Brain On... Having A Pet
Brian Hare, a Professor in Evolutionary Anthropology and author of 'The Genius of Dogs', and Gregory Berns, a Professor of Psychology and neuroeconomics expert, dive into the fascinating bond between humans and their pets. They discuss how oxytocin reveals dogs’ love for us and how our companionship alters their brains. The conversation touches on the emotional healing power of pets, the complexities of dog cognition, and the implications of research on the human-animal relationship. Understanding these dynamics is crucial for empathy and ethical treatment.