
Serious Inquiries Only
Join Thomas for some critical thinking on questions of science, philosophy, skepticism and politics. These serious topics are discussed with some serious guests, but in an entertaining and engaging way! This is not your typical interview podcast; it’s a friendly dialogue, conducted thoughtfully and with plenty of humor. It's Serious Inquiries Only; but like, not boring or anything.
Latest episodes

Jan 1, 2025 • 45min
Trump's Health and Human Services Agency, with Dr. Rick Sullivan
Lydia has spread Opening Arguments' fashwatch to SIO, and we're calling in a doctor to keep it under control! Dr. Rick Sullivan joins us to walk through the Health and Human Services Agency, its various entities, and what kind of impact we might be looking at under the next Trump administration. ProPublica obtained Project 2025 private training videos. Click here to check them out if you dare! Are you an expert in something and want to be on the show? Apply here! Please please pretty please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Dec 12, 2024 • 56min
You Don’t Actually Need to Condemn the Murder of the CEO Guy
I've felt like I wanted to say a ton about this since day 1, but keep holding back. I finally hit brain saturation and just need to share. I think I have a useful way of looking at this whole thing, hope you'll consider it. Oh and also, f--- UnitedHealthcare and f--- the for profit healthcare industry in its entirety. Please read this incredible ProPublica piece. I finally started a monthly donation to them, which I should have long ago. https://www.propublica.org/article/unitedhealth-healthcare-insurance-denial-ulcerative-colitis Are you an expert in something and want to be on the show? Apply here! Please please pretty please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Nov 30, 2024 • 1h 7min
Epidemiologist Claims MAGA Is An Epidemic Caused By "Brain Flaws." Only Problem Is, That's Completely Unscientific and Based On Almost Nothing.
SIO466 - Dr. Gary Slutkin has been cited in Salon and other outlets as an expert epidemiologist who runs an impressive NGO that helps reduce violence. While he may be an epidemiologist, almost everything else about him and his claims seems to be... very likely bull shit. Dr. Jenessa Seymour joins us to break this down. It gets more and more bull shit as we go, and eventually we're both live debunking parts of this nonsense. Are you an expert in something and want to be on the show? Apply here! Please please pretty please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Nov 7, 2024 • 57min
No, She Didn't 'Lose' 15m Democratic Votes
Hey folks, this is more of an SIO, but I recorded a solo show because I have to debunk this myth about Kamala losing 10-15m Democratic votes, and Trump only keeping his same voters from 2020. That isn't correct at all. I also have a million other thoughts that I really just want to get out there and that I hope will be helpful.

Nov 1, 2024 • 57min
SIO464: All About Synesthesia, Part 2
Dr. Jenessa Seymour returns to delve deeper into synesthesia, a captivating neurological phenomenon. She discusses incredible case studies, showcasing individuals who perceive colors that have never been seen. The conversation reveals how synesthetic experiences vary greatly, from linking sounds to colors to feeling sensations through others. Dr. Seymour also shares insights into the brain's adaptability and the interplay between sensory perception and neuroplasticity, making us reconsider how we experience the world around us.

Oct 31, 2024 • 50min
SIO463: Synesthesia - How Does It Work?
Dr. Janessa Seymour is back! This time she teaches us all about synesthesia. How does it work? How many people have it? Are they just faking it? How do we test for it? This episode features one of the most mind-blowing things I've ever heard on this show. I really enjoyed this one! Are you an expert in something and want to be on the show? Apply here! Please please pretty please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Oct 31, 2024 • 1h 2min
SIO462: The Day the Dinos Died
Join Dr. Eric Jaffe, a biology expert and dinosaur aficionado, as he uncovers the dramatic details of the dinosaurs' demise. He reveals the cataclysmic meteor impact that triggered their extinction and explores how life adapted and survived afterward. Delve into the patterns of past mass extinctions and their implications for modern biodiversity. Dr. Jaffe also highlights the fascinating connection between ancient ecosystems and present-day fossil fuels, illustrating the ever-evolving story of life on Earth.

6 snips
Oct 1, 2024 • 1h 1min
SIO461: So You Want To Destroy the Earth...
Astrophysicist Dr. Bryan Gillis returns to craft wild, hypothetical ways to obliterate our planet. From halting the moon's orbit to launching nuclear weapons, he discusses the complex physics behind these catastrophic ideas. They dive into the hilarity of a moonfall scenario, juxtaposed with serious reflections on humanity’s fragile future. The conversation also highlights the dangers of AI and cosmic threats, all wrapped in a playful, light-hearted banter that blends science with absurdity.

Sep 20, 2024 • 53min
SIO460: Actual Experts Debunk the Cass Review
In 2020, the United Kingdom’s (NHS) commissioned an inquiry to provide recommendations for the healthcare of transgender adolescents. It was overseen by a pediatrician named Dr. Hillary Cass and was completed in April 2024. It became known as the Cass Review, and it has since been used to justify depriving a lot of people of the healthcare they badly need. But is it good science? Obviously not. Yale's Integrity Project gathered several actual experts in the field to conduct their own review of the review. The results are not pretty. They published an excellent report entitled "An Evidence-Based Critique of “The Cass Review” on Gender-affirming Care for Adolescent Gender Dysphoria." Three of these experts, Drs. Meredithe McNamara, Kellan Baker, and Ken C. Pang, were kind enough to join us to talk about their findings. It looks to me like the anti-trans side is winning this information war, so please share this far and wide to get the word out! Are you an expert in something and want to be on the show? Apply here! Please please pretty please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Sep 13, 2024 • 54min
SIO459: Understanding CRISPR with Dr. Eric Jaffe
Dr. Eric Jaffe, an expert in CRISPR technology, unpacks the fascinating world of genetic editing. He discusses the historical evolution of CRISPR and how it functions in bacterial immunity. The conversation explores groundbreaking applications in areas like spina bifida research and the controversial use of CRISPR to control mosquito populations. Ethical concerns and potential ecological impacts are examined, offering listeners a thorough understanding of both the promise and perils of this revolutionary technology.
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