

Serious Inquiries Only
seriouspod.com
Join Thomas for some critical thinking on questions of science, philosophy, skepticism and politics. These serious topics are discussed with some serious guests, but in an entertaining and engaging way! This is not your typical interview podcast; it's a friendly dialogue, conducted thoughtfully and with plenty of humor. It's Serious Inquiries Only; but like, not boring or anything.
Episodes
Mentioned books

Jan 7, 2026 • 51min
SIO501: What Pluribus Gets Right about Neuroscience
Subject of much sci-fi media and philosophy discussions, the "hive mind" is also a key element of Vince Gilligan's (Breaking Bad, Better Call Saul) new show, Pluribus. Dr. Jenessa Seymour joins the pod to walk us through examples that we have studied of hive mind behavior (in the insect world), and why we can reasonably assert that you could not maintain your individuality if our brains directly communicated with each other (in the human world). Wolman, D. (2012). A tale of two halves. Nature, 483, 260-263. Split brain patient video demonstration Wittlinger, M., Wehner, R., & Wolf, H. (2006). The ant odometer: Stepping on stilts and stumps. Science, 312, 1965-1967. Penick, C.A. & Smith, A.A. (2015). The true odor of the odorous house ant. American Entomologist, 61, 85-87. Are you an expert in something and want to be on the show? Apply here! Please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Jan 1, 2026 • 1h 13min
SIO500: A New Study Suggests Brain Imaging Might Have Significant Flaws
Brain pics, or they didn't happen? There's a recent study that demonstrates that some brain region activity might interact differently with oxygen than previously assumed. This could upend significant neuroscience research spanning decades. Thankfully SIO has Dr. Jenessa Seymour to come in and break it all down for us! We start with a primer on the science of neuroimaging tools and the images they produce. How in the WORLD can we get a picture of a brain while a person is still alive? What are the things we need to know when evaluating scholarly articles or popular media coverage about the brain that uses these brain "scans" in discussing their results? And what do we need to see next to support the findings of this study that could have incredible ramifications across our understanding of the brain? Epp, S.M., Castrillón, G., Yuan, B. et al. BOLD signal changes can oppose oxygen metabolism across the human cortex. Nat Neurosci (2025). Example structural MRI (sMRI) of a human brain Güttler, F.V., Heinrich, A., Rump, J., de Bucourt, M., Schnackenburg, B., … Teichgräber, U.K. (2012). Magnetic resonance imaging of the active second stage of labour: Proof of principle. European Radiology, 22, 2020–2026 Diffusion Tensor Imaging (DTI) example image Example functional MRI (fMRI) Example fMRI with a more-appropriately blurry sMRI underneath After Warping Options, Configurable Pipeline for the Analysis of Connectomes (0, 4, and 8mm filter images) Jenessa's Brain: Jenessa's brain sMRI Are you an expert in something and want to be on the show? Apply here! Please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Dec 2, 2025 • 1h 10min
SIO499: Trump Is Weaponizing Government Against Political Enemies. Nick Fish, President of American Atheists, on How to Be Prepared
In late September, shortly after declaring antifa a "domestic terrorist", Trump issued a memorandum directing the IRS to investigate tax-exempt organizations that could be "directly or indirectly financing political violence or domestic terrorism" and nonprofit organizations reasonably felt concerned of being targeted. A couple of weeks later, Lydia and Thomas ran into Nick Fish, President of the American Atheists, at California Freethought Day and asked how he and the organization were holding up in light of everything. We're pleased to have Nick on to discuss what nonprofit organizations can do to protect themselves, as well as the people who have supported their mission and the communities they serve, when it is feeling less and less paranoid that the federal government might be coming for you. How can organizations fortify themselves through governing documents and organizational structure to donor databases and retention policies when the President of the United States could very well declare your nonprofit a supporter of domestic terrorism? Countering Domestic Terrorism and Organized Political Violence (NSPM-7) (9/25/2025) Support American Atheists!

Nov 26, 2025 • 1h 9min
SIO498: The Science of Hallucinations, Ear-worms, and Phantom Limbs
Dr. Jenessa Seymour is on to teach us more about the brain! What do hallucinations, ear-worms, and phantom limbs have in common? And is "hallucinating" really a good term for what AI does when it makes something up?

Nov 5, 2025 • 1h 14min
SIO497: The Mamdani Machine Exposed! Part 2
Part 2 of Asra Nomani's insanely terrible Fox News article. Make sure you listened to part 1! This is big, folks. Think Watergate combined with Deflate-gate combined with Christina Applegate combined with the Bowling Green Massacre. THAT's how big of a scandal this is. You thought Zohran Mamdani was just an innocent 34 year old assemblyman who rose to stardom by being an incredibly good candidate and relentless campaigning an economic message in a positive way. But you were an idiot. Dummy. Asra Nomani broke it here, but let Jenessa and I explain it to you because clearly your feeble, gullible brain can't process. information properly.

Nov 4, 2025 • 49min
SIO496: Asra Nomani Has EXPOSED the Mamdani Machine!
Part 1. This is big, folks. Think Watergate combined with Deflate-gate combined with Christina Applegate combined with the Bowling Green Massacre. THAT's how big of a scandal this is. You thought Zohran Mamdani was just an innocent 34 year old assemblyman who rose to stardom by being an incredibly good candidate and relentless campaigning an economic message in a positive way. But you were an idiot. Dummy. Asra Nomani broke it here, but let Jenessa and I explain it to you because clearly your feeble, gullible brain can't process. information properly.

Oct 30, 2025 • 58min
SIO495: Can AI Chatbots Make You Delusional? A Psychologist Explains
Stormy Decisis AKA Dr. Alan Smerbeck is back! With multiple stories in the news of AI Chatbots potentially driving people to delusion or psychosis, Stormy wanted to explain to us what's going on and what the actual differences are between psychosis, delusions, schizophrenia, and more. Visit Stormy's amazing project, sharebannedbooks.com!

Oct 24, 2025 • 49min
SIO494: Autism and ADHD, Part 2
***This is a two-parter. Listen to part 1! Previously, the leading theory was that kids with autism and/or ADHD had mental health struggles due to emotional regulation issues or other direct elements of their neurodivergence. But what if it's actually that they have to deal with more stressors than the other kids? Dr. Jenessa Seymour, fellow haver of ADHD, is here to break it down for us!

Oct 24, 2025 • 1h 1min
SIO493: Kids with ADHD/Autism Struggle with Mental Health. New Study Says Maybe It's the Stress of Being Different
Previously, the leading theory was that kids with autism and/or ADHD had mental health struggles due to emotional regulation issues or other direct elements of their neurodivergence. But what if it's actually that they have to deal with more stressors than the other kids? Dr. Jenessa Seymour, fellow haver of ADHD, is here to break it down for us! This is a 2-parter! Get part 2 on patreon.com/seriouspod, or just wait a little!

Sep 26, 2025 • 55min
SIO492: How Radicalized Was Kirk's Killer, Really?
Part 2 of my thoughts and observations based on all the info I could gather on Tyler Robinson. I think there's an aspect to him that isn't being emphasized enough that might help explain why he did what he did.


