Oncotarget

Researchers discuss the potential of targeting DLST for cancer therapy in neuroblastoma and TNBC, with implications for inducing apoptosis. They identify approved drugs with high effectiveness for DLST+ tumor cell lines, suggesting vulnerability to protein kinase inhibitors and ERK/MAPK pathway targeting drugs.

Researchers explore the potential of STRO-001 in B-cell NHL, showing potent cytotoxicity in cancer cell lines, promising results in preclinical studies for tumor regression and eradication

Researchers discuss the chemotherapeutic potential of 15d-PMJ2 in inducing cell death in melanoma and squamous cell carcinoma cell lines. The involvement of PERK, IP3R, and mitochondrial calcium signaling pathways in this process is highlighted. Experiments reveal the importance of ER stress, calcium release, and mitochondrial permeability transition pore in the mechanism of cell death.

Researcher Michèle Welti discusses the impact of Covid-19 on managing patients with metastatic melanoma. The study analyzed patients receiving therapy and their Covid-19 outcomes. Topics include treatment regimens, severity of Covid-19 courses, and challenges faced during the pandemic.

Researchers discuss the resistance of MMTV New TATTAC mice to anti-PD-1 therapy, linked to macrophage infiltration, fibrosis, and the Wnt pathway in breast cancer. They monitored drug response and identified processes associated with lack of responsiveness to the treatment.

Researchers discuss the development of a novel antibody drug conjugate ASP1235 targeting FLT3 in AML, with potential for safer and more effective treatment. The podcast highlights the importance of reducing off-target toxicity in older AML patients and the efficacy of combining ASP1235 with venetoclax and azacitidine. The triple combination therapy shows promising results in preclinical models, offering hope for refractory AML and potential applications in FLT3 positive cancers.

Researchers Tomofumi Miura and Shuichi Mitsunaga discuss using serum microRNAs as criteria for early palliative care in cancer patients. They explore the potential of miRNAs as biomarkers for predicting referral to palliative care services in advanced cancer patients undergoing anti-tumor treatment.

A discussion on the impact of pyrethroid derivatives on human cells, including their role in inducing cellular changes like lipid peroxidation and altered transcription factors. The study highlights potential risks of these derivatives in promoting hematological cancers and immune-related disorders.

Researchers discuss the potential of plasma growth hormone as a predictive biomarker for response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients, showing promising results in predicting treatment outcomes.

Explore the fascinating world of exosomes and their potential in precision medicine. Learn about bioorthogonal chemistry and its innovative approach to targeting exosomes for drug delivery. Discover the challenges and opportunities in leveraging exosomes for cell-to-cell communication. Dive into the transformative impact of bioorthogonal reactions on clinical biomedical practices.