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Oncotarget

Deconstructing the Role of MALAT1 in MAPK-Signaling in Melanoma

May 30, 2023
Researchers discuss the role of MALAT1 in regulating gene and protein expression in the MAPK pathway in melanoma. Antisense oligonucleotide treatment decreases BRAF levels and MALAT1 shows increased correlation with MAPK genes in patient samples. Potential therapeutic advances in MAPK pathway regulation.
03:19

Podcast summary created with Snipd AI

Quick takeaways

  • MALAT1 plays a vital role in gene regulation within the MAPK pathway in melanoma.
  • ASO treatment of MALAT1 reduced BRAF levels and impacted gene regulation in melanoma patients.

Deep dives

Role of MA-LAT-1 in MAPK Signaling in Melanoma

MA-LAT-1, a long non-coding RNA, plays a crucial role in the regulation of gene and protein expression in the MAPK Pathway, particularly in melanoma. Researchers demonstrated that MA-LAT-1 ASO treatment decreased BRAF RNA expression and protein levels, impacting gene regulation in melanoma patients. The study revealed that MA-LAT-1 is downregulated in melanoma, and its inhibition through ASO treatment led to reduced growth of melanoma cell lines, even in cases of resistance to MEK inhibition. Additionally, MA-LAT-1 ASO treatment significantly inhibited colony formation in vitro and reduced tumor growth in vivo, without causing any toxic side effects.

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