Oncotarget

Researcher Hossein Tavana and expert Gary D. Luker discuss Cancer-associated fibroblasts' role in tumor microenvironment, challenges in targeting them for therapies, and the potential of personalized cancer treatments through better understanding of CAFs.

Researchers Kamrul Hasan and Thomas J. Kipps from the University of California discuss the impact of cortactin in cancer progression, focusing on its role in promoting cell migration and metastasis. They explore its interactions with actin-related proteins, signaling pathways, and its association with cancers like CLL and breast cancer.

The podcast discusses the presence of Impact Journals at the AACR Annual Meeting 2023, emphasizing their focus on cancer and aging research. They invite visitors to connect with the team at Booth 2642 during the event.

Researchers discuss targeting pre-leukemic cells to prevent childhood B-ALL, focusing on genetic mutations and environmental triggers. They explore the efficacy of Roxelitinib in reducing B-ALL incidence in mice and propose ongoing research for preventative strategies against childhood leukemia.

Researchers discuss the impact of angulin-1/LSR downregulation on malignancy in lung adenocarcinoma. They explore abnormal claudin-2 expression and the effects of angulin-1/LSR loss on lung adenocarcinoma cell lines. The study also examines therapeutic approaches for lung adenocarcinoma via cell metabolism modulation, highlighting the potential of AG1478 and EW7197 as treatments.

Researchers discuss the effectiveness of Polyisoprenylated Cysteinyl Amide Inhibitors in depleting G-proteins in lung and breast cancer cells. The study shows promising results with significant decreases in levels of key G proteins, offering potential as anti-cancer agents.

Researchers Fang Cheng, Victor Chérouvrier Hansson, Grigorios Georgolopoulos, and Katrin discuss their recent study on Glypican-1 in cancer. They reveal the correlation between GPC-1 expression and poor prognosis in multiple cancer types. Targeting GPC-1 resulted in cancer cell growth inhibition, highlighting its potential in precision cancer treatment.

Discover the complexity of genetic landscape and microenvironment in Osteosarcoma tumors through unsupervised machine learning algorithms. Explore stratification based on gene expression modules enriched for immune microenvironment and tumor phenotypic traits for improved treatment strategies.

Researchers discuss the unconventional protein secretion (UPS) in cancer, highlighting pathways like lysosome-mediated and exosome-mediated. They dive into the unique mechanisms observed in liver cancer cells, emphasizing the importance of differentiating between leaked and actively secreted proteins for targeted therapies.

Exploring the impact of MTAP loss on purine synthesis in metastatic breast cancer patients, analyzing genomic alterations and treatment strategies based on a recent study.