Oncotarget

Researchers conducted a study on using Metformin to prevent Metabolic Syndrome during Androgen Deprivation Therapy for advanced prostate cancer. The results showed no reduction in the risk of ADT-related Metabolic Syndrome or significant changes in PSA response.

Explore the history and impact of the Ride for Roswell charity bike ride event in Buffalo, NY. Learn about the significant contributions towards cancer research and patient care. Discover the fundraising rewards and team sponsorships available for the 2023 event, including support from scientific journals OncoTarget and Aging.

The podcast explores the role of ACSL4 in quadruple negative breast cancer as a potential biomarker, treatment predictor, and therapeutic target. ACSL4 is a lipid metabolic enzyme differentially expressed in breast tumors, with highest expression in mesenchymal and basal-like subtypes. Researcher Marie E. Monaco discusses the potential of utilizing ACSL4 status for predicting response to treatment regimens.

Researchers discuss the novel small molecule LP-284's effectiveness in targeting non-Hodgkin's lymphoma by inducing repair of DNA damage, potentially offering a promising treatment option for refractory NHL cases.

Researchers Betlem Mezquita, Marjorie Reyes-Farias, and Miquel Pons discuss targeting the Src N-terminal regulatory element in cancer. They explore why specific inhibition of Src is crucial for effective cancer treatment and highlight the significance of the SNRE region in cancer progression and potential therapeutic implications.

Exploring the value of chemotherapy after immunotherapy for advanced lung cancer treatment. Discussing the efficacy of DASA Taxil and its impact on patients. Highlighting the evolving treatment landscape and importance of considering chemotherapy in advanced lung cancer cases.

Researchers discuss the connection between BORIS gene mutations and breast cancer progression, revealing frequent mutations and heightened protein expression in breast carcinoma cases

Researchers discuss the role of MALAT1 in regulating gene and protein expression in the MAPK pathway in melanoma. Antisense oligonucleotide treatment decreases BRAF levels and MALAT1 shows increased correlation with MAPK genes in patient samples. Potential therapeutic advances in MAPK pathway regulation.

The podcast delves into the intriguing role of the creatine shuttle in cancer metabolism, specifically its potential in tackling colorectal cancer. Researchers explore how inhibiting creatine kinase B and mitochondrial creatine kinase can suppress growth, stemness, and metastasis in colorectal cancer cells, offering a promising therapeutic strategy.

Dr. Gopal C. Kundu from KIIT Deemed to be University in Odisha, India, discusses the molecular dialogue between tumor cells and fibroblasts. They delve into topics such as the role of cancer-associated fibroblasts in tumor growth, the transformation of fibroblasts into myofibroblasts, and proposing a combined therapy strategy to target osteopontin signaling in both fibroblasts and cancer cells to combat chemoresistance.