Oncotarget
Behind the Study: Molecular Dialogue Between Tumor Cells and Fibroblasts
May 24, 2023
Dr. Gopal C. Kundu from KIIT Deemed to be University in Odisha, India, discusses the molecular dialogue between tumor cells and fibroblasts. They delve into topics such as the role of cancer-associated fibroblasts in tumor growth, the transformation of fibroblasts into myofibroblasts, and proposing a combined therapy strategy to target osteopontin signaling in both fibroblasts and cancer cells to combat chemoresistance.
06:59
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Quick takeaways
- Understanding the molecular dialogue between tumor cells and fibroblasts is crucial for combating drug resistance in breast cancer.
- Targeting osteopontin-regulated signaling in alpha-SMA positive cancer-associated fibroblasts shows promise for combination therapy in breast cancer treatment.
Deep dives
Studies on Cancer-Associated Fiber Blast in Breast Cancer
The podcast discusses research conducted over the past 25 years on the tumor microenvironment in breast cancer, focusing on stromal cells like cancer-associated fiber blast. The studies have delved into the proteins and genes expressed by these cells and their role in controlling tumor growth, angiogenesis, and metastasis. Heterogeneous cancer-associated fiber blast subtypes have been identified, with differentiation into myofibroblast impacting tumor progression in various cancers.
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