The Fellow on Call: The Heme/Onc Podcast

In this episode, we start with a little bit of story time about the history of myeloma treatments and how we got to the present day. We then finish off the episode with how this information helped us treat transplant ineligible patients. Content:- What is the history of myeloma treatment? How did we get to where we are today? - How do we approach treatment in transplant ineligible patients? - What are the key trials that every fellow needs to know? - Links to key trialsWant to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this continuation of our myeloma series, we build on our prior discussion about myeloma pharmacology, this time discussing how to select the optimal regimen for treatment of our patients.Content:- What are the phases of multiple myeloma treatment?- How do we determine transplant eligibility?- What does doublet, triplet, and quadruplet therapy mean? - What categorizes "high risk" myeloma?- What are the current standards of care for transplant eligible patients? - Where does "CyBorD" fit in for treatment? - When do we consider adding daratumumab? - Links to key trialsThis episode has been sponsored by Primum. To sign up for a free account, check out: tfoc.primum.co.Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this continuation of our myeloma series, we begin our discussion about treatment options for multiple myeloma, focusing first on pharmacology. We are so thrilled to have a special guest, Kathryn Maples, PharmD, BCOP who is a clinical pharmacy specialist in Multiple Myeloma at the Winship Cancer Institute of Emory Healthcare in Atlanta, Georgia!Content:- What are common drugs we use in "triplet regimens"? "quadruple therapy"? - What considerations must we take into account when prescribing commonly used medications in myeloma? - How should we counsel our patients? - What about supportive care?- How and when do we make dose adjustments? - This episode is SO eye-opening about the "behind the scenes" of myeloma care that physicians do not seeWant to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

The podcast discusses the progression from MGUS to multiple myeloma and how to risk stratify patients with a myeloma diagnosis. It explores the role of FISH/karyotype in risk stratification and how to gauge disease response and treatment response. The episode also touches on the importance of minimal residual disease (MRD) in myeloma.

In today’s episode, we continue our myeloma series, this time we’ll delve deeper into the spectrum of plasma cell dyscrasias, including defining MGUS, discussing surveillance of MGUS, defining smoldering myeloma (SM). We are slowly inching our discussion towards the diagnosis of Multiple myeloma (MM)!Content:- Defining MGUS- Discussing risk of progression of MGUS to MM- How to interpret free light chains in renal failure- How do we monitor MGUS patients?- When do we do additional testing in MGUS?- What is smoldering myeloma?- What are myeloma defining events?- How do we risk stratify SM patients?- How do we monitor SM patients? Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesThis episode has been sponsored by Primum. To sign up for a free account, check out: tfoc.primum.co Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In the first episode in our highly-anticipated multiple myeloma series, we begin our discussion about introduction to testing/workup for plasma cell dyscrasias and having our initial discussion about monoclonal gammopathy of undetermined significance (MGUS). Contents:- What is a plasma cell ?- What is a plasma cell dyscrasia?- What is an "SPEP"?-What is "immunofixation"?-What are "serum free light chains"?-Checking UPEP-Does everyone need a bone marrow biopsy and/or additional workup?-What is MGUS?Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesThis episode has been sponsored by Primum. To sign up for a free account, check out: tfoc.primum.co Love what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this episode, we discuss the acute management of the bleeding patient with acquired hemophilia. Prior to starting this episode, we highly recommend you listen to Episode 036 to review: - Approach to Hemophilia (physical exam, workup)- Review coagulation cascade Contents:- When to suspect acquired hemophilia?- Mixing studies in acquired hemophilia patients - What are Bethesda Units and why are they important?- How do we treat patients with acquired hemophilia? - How do we stabilize the acute bleed?- How do we treat the underlying cause? Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this episode, we discuss the acute management of the bleeding patient with hemophilia including factor replacement. Contents:- Factor replacement guidelines for Hemophilia A vs. Hemophilia B in the patient with an acute bleed- Management of patients taking emicizumab- Alternative/adjunctive options for treatment of an acute bleedWant to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this episode, we discuss the fundamentals and approaches to chronic management and treatment for patients with known inherited hemophilia. Contents:- What is hemophilia?- How is it inherited? - How do we grade the severity of one's hemophilia? - Chronic management of hemophilia - Mechanism of Emicizumab (Hemlibra)Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this episode, we break down the initial approach to the evaluation of a patient with a suspected bleeding disorder, particularly in regards to hemophilia, including standardized bleeding assessment tools, the basics of the coagulation cascade, and mixing studies. Contents: - "The Fellow on Call" Bleeding assessment!- Important tips for your physical exam - How do we think about bleeding disorders?- What is the basic work-up of a suspected bleeding disorder- Review of the coagulation cascade- How to assess an abnormal PT/PTT Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast