The Fellow on Call: The Heme/Onc Podcast cover image

The Fellow on Call: The Heme/Onc Podcast

Episode 050: #NephMadness Onconephrology - ICI-Associated AKI and Chemotherapy-Related Hypomagnesemia

Mar 22, 2023
Dr. Matthew Abramson, Dr. Timothy Yau, and Dr. Scott Stockholm discuss immune checkpoint inhibitor-related AKIs and hypomagnesia in patients. They cover topics such as the mechanism and etiology of immune checkpoint inhibitor-associated AKIs, how to work them up and treat them, and the use of ICI in patients with kidney transplants. They also discuss the symptoms and management of hypomagnesemia, as well as drugs associated with it.
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Quick takeaways

  • Chemotherapy agents can cause hypomagnesemia in cancer patients, which can be managed through magnesium supplementation.
  • Immune checkpoint inhibitors can lead to hypomagnesemia in cancer patients, and caution should be exercised when rechallenging transplant patients with these inhibitors to avoid graft rejection.

Deep dives

Chemotherapy-induced Hypomagnesemia: Causes and Management

Chemotherapy agents such as cisplatin and EGFR TKIs can cause hypomagnesemia in cancer patients. Hypomagnesemia can lead to various symptoms such as muscle cramps, seizures, and cardiac arrhythmias. Treatment options include magnesium supplementation through oral magnesium or IV magnesium, depending on the severity of the hypomagnesemia. Dietary changes, such as consuming foods rich in magnesium, can also help in replenishing magnesium levels.

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