Philosopher and author L.A. Paul talks about her book Transformative Experience with EconTalk host Russ Roberts. Paul explores the uncertainties that surround the transformative experiences that we choose and that happen to us without choosing. How should we think about the morality and personal impact of these kinds of experiences, especially when some decisions are very hard or impossible to reverse? Examples include becoming a vampire, having children, religion, and other life experiences and choices.

Physicist and author Alan Lightman talks with EconTalk host Russ Roberts about the origins of the universe, meaning, transcendence, and the relationship between science and religion.

Oncologist, author, and podcaster Vinay Prasad talks about his book Malignant with EconTalk host Russ Roberts. Prasad lays out the conflicts of interest and scientific challenges that make drugs that fight cancer so disappointing at times. The conversation looks at how policy changes might improve the incentives facing doctors, pharmaceutical companies, and patients.

Economist Ed Leamer of UCLA talks about manufacturing, effort, and inequality with EconTalk host Russ Roberts. The conversation draws on recent empirical work of Leamer's on how measured inequality is affected by the work effort of Americans at different levels of education. The conversation ends with a discussion of how education can be transformed when it is more personal and allows the student to explore and discover under the guidance of a teacher.

Economist Arnold Kling discusses the revised edition of his book on politics at the Cato Institute, touching on the evolution of political landscapes and the impact of media on demonization. He explores the challenges of online interactions, the erosion of trust in elites, and the changing intellectual environment in universities.

Jenny Schuetz of the Brookings Institution talks with EconTalk host Russ Roberts about zoning, boarding houses, real estate development, and the housing market.

Author and oncologist Azra Raza talks about her book The First Cell with EconTalk host Russ Roberts. Raza argues that we have made little progress in fighting cancer over the last 50 years. The tools available to oncologists haven't changed much--the bulk of the progress that has been made has been through earlier and earlier detection rather than more effective or compassionate treatment options. Raza wants to see a different approach from the current strategy of marginal improvements on narrowly defined problems at the cellular level. Instead, she suggests an alternative approach that might better take account of the complexity of human beings and the way that cancer morphs and spreads differently across people and even within individuals. The conversation includes the challenges of dealing with dying patients, the importance of listening, and the bittersweet nature of our mortality.

Economist and infovore Tyler Cowen of George Mason University talks with EconTalk host Russ Roberts about the political, social, and economic aspects of the COVID-19 pandemic.

Author and conservationist Isabella Tree talks about her book Wilding with EconTalk host Russ Roberts. Tree and her husband decided to turn their 3500 acre farm, the Knepp Castle Estate, into something wilder, a place for wild ponies, wild pigs, wild oxen, and an ever-wider variety of birds and bugs. The conversation covers the re-wilding phenomenon, the complexity of natural systems, and the nature of emergent order.

Economist and author Richard Davies talks about his book Extreme Economies with EconTalk host Russ Roberts. The conversation explores economic life in extreme situations. Examples discussed are the Angola State Penitentiary in Louisiana, two Syrian refugee camps in Jordan, the rain forest in the Darien Gap in Panama, and Kinshasa, the largest city in the Democratic Republic of Congo. This is an economic and journalistic tour de force as Davies shares insights from his encounters with people around the world struggling to trade and prosper in extreme environments.