Noor Siddiqui, founder of Orchid, discusses the culture of San Francisco, embryo screening for IVF, genetic predisposition to disease, and the importance of making reproduction safe. She shares insights on advancing technology, predicting the field's future, and the benefits of genetic testing for families outside of IVF.

Dive into the philosophy of the Fourth Way for self-improvement and spiritual growth. Explore the four ways of being, befriending your centers, and the keys to the universe. Uncover the importance of harmonious inner development and achieving a higher state of consciousness. Connect with mystical teachings, laws of three and seven, and the journey to objective consciousness.

Cognitive neuroscientist Mona Sobhani shares her journey from materialism to spirituality, discussing psi-phenomena research, quantum science's impact on consciousness, transcendent technology, psychedelics, and bringing humanity back into science.

Ellen Fishbein, a writing coach and author, discusses traditional publishing disrespecting intelligent readers, advice for aspiring authors, insights from Shakespeare's sonnets, the impact of Herman Hesse's works, using AI in book writing, changing role of agents, and innovating in the publishing industry.

John A. Paulos, Professor, Mathematician, and Writer, discusses math education, puzzles, cognitive biases, innumeracy, randomness ignorance, anchoring bias, Monty Hall problem, ideal math courses, nudging, and more. Topics include practical math teaching methods, misconceptions in statistics, strategies for confidence intervals, critical thinking through math, nudging in behavioral economics, and math in financial disasters.

Award-winning documentary filmmaker Chris Wilcha discusses his latest film 'Flipside,' exploring creative failure, abandoned projects, and rekindled passion. He shares stories of reviving a record store, encountering Ira Glass's creative rebirth, and uncovering unique connections in the music world. The podcast delves into the challenges of balancing artistic aspirations with commercial realities in the filmmaking industry, reflecting on the nostalgia of a beloved record store and discussing the evolving landscape of documentary filmmaking.

Entrepreneur, writer, and comedian Bridget Phetasy discusses the state of comedy in America, comedic dissidence, the role of humor as a weapon, luxury beliefs, and the societal utility of comedy in a fragmented cultural landscape.

Porter Braswell, CEO of 2045 Studio, discusses empowering professionals of color, building trust in communities, lessons from Magic Johnson's mentorship, and the importance of human capital. He shares insights on networking, partnerships, and the value of inclusive spaces in fostering leadership impact.

Grant Mitchell, entrepreneur in health and AI, discusses AI in drug repurposing, the Organizational Problem in Pharma, Biomedical Knowledge Graphs, risks in AI-driven drug discovery, neglected knowledge, and the role of translators. He also talks about innovative drug repurposing, the potential of AI in patient relief, constructing biomedical knowledge graphs, and revolutionizing drug repurposing in healthcare.

Author and friend-of-the-show Jimmy Soni discusses the future of publishing, the changing world of book marketing, the courage of creative risk, and emphasizes the importance of trying new things. Topics include traditional publishing stasis, talent spotting, self-publishing challenges, and the value of collaboration in publishing.