The Mind-Gut Conversation Podcast

In this episode of The Mind–Gut Conversation, Dr. Emeran Mayer sits down with Will Bulsiewicz, board-certified gastroenterologist, New York Times bestselling author, and one of today’s leading voices in microbiome science.Drawing from his newest book, Plant-Powered Plus, Dr. Bulsiewicz explores why chronic, low-grade immune activation has become so widespread—and how modern lifestyles are keeping our immune system permanently switched on.Together, they examine the deep connections between diet, the microbiome, the immune system, and inflammation, unpacking how evolutionary mismatches, ultra-processed foods, low fiber intake, chronic stress, and social disconnection are reshaping human health. The conversation moves beyond symptoms to address root causes, highlighting why restoring health requires rethinking how we eat, live, and connect.This wide-ranging discussion blends cutting-edge science with clinical insight, offering a grounded, practical perspective on how small, sustainable changes can meaningfully reduce inflammation and support long-term well-being.Topics discussed include:• What inflammation really is—and why it’s no longer just an acute response• How the gut microbiome and immune system interact• The role of fiber, polyphenols, and microbial metabolites in regulating inflammation• Why modern environments clash with human biology• How lifestyle factors like stress, loneliness, and purpose influence immune healthThis is a practical, evidence-based discussion for anyone seeking to understand how modern lifestyle factors shape immune health, inflammation, and long-term well-being.Please leave any comments or feedback on the episode — we’d love to hear your thoughts.----------------------------This episode is brought to you by Mayer Nutrition. If you are interested in trying Synaptic Bloom, our high-potency Quercetin + supporting polyphenols blend, you can visit mayernutrition.com, and use our exclusive podcast discount code: MINDGUT for 10% off your first order!----------------------------Connect with Dr. Mayer:Website: https://www.emeranmayer.comInstagram: https://www.instagram.com/emeranmayer/X (Twitter): https://www.twitter.com/emeranmayermdFacebook: https://www.facebook.com/EmeranMayerMD/LinkedIn: https://www.linkedin.com/in/emeranmayer/----------------------------Chapters:0:00 – Introduction 3:00 – Purpose, Medicine, and the Evolution of Gut Health 7:00 – What Inflammation Really Is 12:30 – Modern Life and the Immune System 18:00 – The Gut Microbiome and Immune Activation 26:00 – Diet, Fiber, and Microbial Health 38:21 – Mayer Nutrition40:15 – Lifestyle, Stress, and Social Connection 49:00 – Technology, Medicine, and the Future of Health 1:05:00 – Practical Takeaways and Closing Reflections

In this episode of The Mind-Gut Conversation, Dr. Emeran Mayer sits down with Dr. Lauren DeDecker, a board-certified internal medicine physician with training in nutrition and integrative medicine, to explain how gut health is approached in real-world primary care.They discuss why fiber and plant diversity remain foundational for digestive and metabolic health, how microbiome research reshaped modern medicine, and why popular diet trends often miss the bigger picture. The conversation also covers SIBO, common gut-related diagnoses, and how GLP-1 medications are changing what we understand about appetite, inflammation, and metabolism.Key Topics Covered:• Gut health and the brain-gut-microbiome system• Fiber, fermented foods, and microbiome diversity• SIBO, overdiagnosis, and gut symptoms• Popular diets: carnivore, keto, Mediterranean• GLP-1 medications, appetite regulation, and inflammationThis is a practical, evidence-based discussion for anyone interested in supporting gut health — whether navigating digestive concerns personally or working with patients in a clinical setting.Please leave any comments or feedback on the episode — we’d love to hear your thoughts.----------------------------Connect with Dr. Mayer:Website: https://www.emeranmayer.comInstagram: https://www.instagram.com/emeranmayer/X (Twitter): https://www.twitter.com/emeranmayermdFacebook: https://www.facebook.com/EmeranMayerMD/LinkedIn: https://www.linkedin.com/in/emeranmayer/-----------------------------Chapters:0:00 – Introduction to Gut Health & Integrative Medicine1:30 – From Conventional Medicine to Integrative Care6:30 – Why Gut Health Became Mainstream (Microbiome Science)12:30 – Fiber, Plant Diversity & Foundational Gut Health18:45 – Diet Trends Explained: Carnivore, Keto & Mediterranean22:30 – SIBO, Gut Symptoms & Overdiagnosis31:45 – GLP-1 Medications, Appetite & Metabolism41:15 – The Future of Gut Health & Lifestyle Medicine

In this episode of The Mind-Gut Conversation, Dr. Emeran Mayer sits down with Wolfgang Puck, one of the most iconic chefs of our time, for an intimate conversation about the life experiences, creative influences, and personal philosophy that shaped his extraordinary career.Puck reflects on his difficult childhood in Austria and how the kitchen became both refuge and calling. He shares the pivotal moments — working under a visionary French chef, discovering the power of simple dishes made from exceptional ingredients, and redefining California cuisine — that built the foundation of his global culinary empire.Together, they explore:• How early adversity shaped Puck’s resilience and drive• The pivotal mentor who transformed his relationship to flavor and hospitality• Why simplicity, curiosity, and world-class ingredients remain his guiding principles• The evolution of American dining and why taste is central to healthier eating• How passion, purpose, and creativity fuel energy and longevity well into his 70sThis conversation reveals the mindset behind a cultural icon — one who continues to innovate, inspire, and live fully through his craft.----------------------------Connect with Dr. Mayer:Website: https://www.emeranmayer.comInstagram: https://www.instagram.com/emeranmayer/X (Twitter): https://www.twitter.com/emeranmayermdFacebook: https://www.facebook.com/EmeranMayerMD/LinkedIn: https://www.linkedin.com/in/emeranmayer/Chapters:00:00 – Early Hardship & Discovering the Kitchen08:40 – Mentorship in France & Shaping a Culinary Philosophy14:00 – Coming to America: Reinvention in New York & LA23:20 – Creating California Cuisine & Building Spago31:30 – Flavor, Health, and the Future of Eating49:50 – Passion, Curiosity & Longevity

Join Kate Scarlata, a leading dietitian and bestselling author specializing in IBS and digestive health, as she dives deep into gut wellness. She shares her personal journey through gastrointestinal challenges and how it shaped her career. Discover why the Low FODMAP diet is not a one-size-fits-all solution and learn about the nuances of SIBO diagnosis. Kate also uncovers the complexities of gluten sensitivity and the various causes of bloating beyond diet. Plus, find out why detox diets are more myth than miracle!

Dr. Emeran Mayer sits down with Taylor Bell, an Ivy League–educated former management consultant turned full-time YouTuber, for a candid conversation on authenticity, ambition, and the health consequences of living out of alignment with your true values.Through her story of leaving a high-pressure corporate career to pursue creative entrepreneurship, Taylor shares what it means to redefine success, listen to your inner voice, and create a life rooted in purpose and well-being.Together, they explore the psychological effects of cognitive dissonance, how chronic stress shows up in the body, especially through the brain-gut-microbiome system, and why self-trust and intentional living are essential for both mental and physical health.Dr. Mayer also discusses the physiological impact of chronic stress, the concept of allostatic load, and practical tools such as diaphragmatic breathing that can help restore balance and resilience in a world of constant pressure and comparison.Key Topics Covered:• The link between cognitive dissonance, stress, and physical health• How authenticity and purpose shape mental well-being• The hidden costs of over-optimization and burnout• Simple ways to live and work with greater intention• Why listening to your body is more powerful than tracking every metric• Breathing techniques to reset the nervous system and calm the mindThis episode is both inspiring and deeply practical — a reminder that true success isn’t about constant achievement, but about alignment, fulfillment, and trusting the wisdom of your own body.As always, we invite you to share your thoughts in the comments and subscribe for more episodes exploring the science of brain–body health.This episode is brought to you by Mayer Nutrition. If you are interested in trying Synaptic Bloom, our high-potency Quercetin + supporting polyphenols blend, you can visit mayernutrition.com, and use our exclusive podcast discount code: MINDGUT for 10% off your first order!Connect with Dr. Mayer:Website: https://www.emeranmayer.comInstagram: https://www.instagram.com/emeranmayer/X (Twitter): https://www.twitter.com/emeranmayermdFacebook: https://www.facebook.com/EmeranMayerMD/LinkedIn: https://www.linkedin.com/in/emeranmayer/Chapters:0:00 - 2:30 Introduction2:30 - 4:59 Career Shift from Consulting to YouTuber4:59 - 7:25 Synchronicity & Self-Trust7:25 - 17:38 Cognitive Dissonance, Gut Feelings & Finding Your True Passion17:38 - 19:16 Passion & Happiness19:16 - 23:53 Career Stress & Stress Response System23:53 - 25:33 Sponsor: Mayer Nutrition25:33 - 31:05 We've Taken Health Optimization Too Far31:05 - 32:30 Keys to Health & Longevity32:30 - 36:38 Chronic Stress, Brain-Gut-Microbiome System, Allostatic Load36:38 - 41:47 Practical Tips to Better Adapt to Stress41:47 - 46:27 Breathing Techniques Dr. Mayer Teaches His Patients46:27 - 49:01 Closing Remarks, Advice to People Dealing with Career Changes

Dr. Emeran Mayer sits down with Dr. Drew Ramsey, psychiatrist, author, and pioneer in nutritional psychiatry, for a thought-provoking conversation on how we can proactively strengthen and protect our mental health.Drawing from his new book, Healing the Modern Brain: Nine Tenets to Build Mental Fitness and Revitalize Your Mind, Dr. Ramsey explains what it means to develop “mental fitness” and why small, intentional habits around food, sleep, movement, purpose, and connection can transform how we feel and function in the modern world.Together, they explore the roots of today’s mental health crisis, how modern food and technology are reshaping the brain, and what science reveals about our innate capacity for resilience, growth, and joy.Key Topics Covered:• What “mental fitness” really means and how to build it• The Nine Tenets for strengthening the brain and emotional resilience• How diet and the microbiome influence mood and mental health• Why connection, engagement, and purpose are essential for well-being• How modern stressors from processed food to digital overload impact the brain• Practical steps to rewire your brain and revitalize your mindThis episode is both empowering and deeply practical, reminding us that our brains are not just meant to survive the modern world but to grow, connect, and thrive within it.As always, we invite you to share your thoughts in the comments and subscribe for more episodes exploring the science of mind–body health.Connect with Dr. Mayer:Website: https://www.emeranmayer.comInstagram: https://www.instagram.com/emeranmayer/X: https://www.twitter.com/emeranmayermdFacebook: https://www.facebook.com/EmeranMayerMD/LinkedIn: https://www.linkedin.com/in/emeranmayer/

Dr. Emeran Mayer welcomes Peter Crone, widely known as The Mind Architect, for a profound conversation on healing trauma, dissolving limiting subconscious beliefs, and unlocking human potential.Peter shares how early life experiences shape the subconscious mind, often creating patterns of fear, anxiety, and self-judgment that hold us back. He explains how shifting awareness and reframing our narratives can open the door to greater freedom, love, and authentic living. Their dialogue bridges Eastern philosophy with modern psychology, offering practical steps to move beyond suffering into resilience and possibility.You’ll also hear how the science of the subconscious intersects with personal transformation, and why cultivating presence can help us break free from being controlled by the past or the future.Key Topics Covered:• Letting go of past and future narratives that shape behavior• The roots of feeling “not good enough” and how to transcend it• Redefining peace as success through radical acceptance• Insights from Eastern philosophy and modern psychology• How trauma imprints the subconscious and shapes behavior• Living with more presence, authenticity, and easeThis episode is both a roadmap and an invitation. By releasing limiting beliefs and healing hidden wounds, we can expand into our fullest human potential.As always, please leave any questions or comments below.We hope you enjoy the episode!This episode is brought to you by Mayer Nutrition. If you are interested in trying Synaptic Bloom, our high-potency Quercetin + supporting polyphenols blend, you can visit mayernutrition.com & use our exclusive podcast discount code MINDGUT for 10% off your first order.Connect with Dr. Mayer:Website: https://www.emeranmayer.comInstagram: https://www.instagram.com/emeranmayerX: https://www.x.com/emeranmayermdFacebook: https://www.facebook.com/EmeranMayerMD/LinkedIn: https://www.linkedin.com/in/emeranmayer/Chapters:00:00 – Introduction01:32 – Peter Crone’s journey and life lessons04:56 – Spirituality, Buddhism, and Eastern influences11:36 – Living in the present and letting go of the past19:13 – Trauma, healing, and the power of choice25:55 – Reprogramming the subconscious mind29:14 – Advertisement: Mayer Nutrition30:51 – Why we feel “not good enough”33:32 – Success, suffering, and hidden drivers of achievement36:41 – Personal reflections and growth37:38 – Psychedelics and altered states of awareness44:27 – The brain as a prediction machine51:26 – Aging, vitality, and redefining time56:14 – Closing thoughts

Dr. Emeran Mayer welcomes Dr. Suzanne Gilberg-Lenz, physician, author, and women’s health advocate, for an in-depth discussion on menopause, hormone therapy, and the integration of holistic practices into modern medicine.Dr. Gilberg shares her path into women’s health, including the creation of the Menopause Bootcamp to address the lack of education and awareness around menopause. She explains why estrogen plays a vital role in women’s health beyond reproduction and how the Women’s Health Initiative reshaped, and sometimes restricted, perceptions of hormone therapy. The conversation also examines gender bias in medical research, the need for updated guidelines, and the emerging potential of psychedelics in women’s health care.You’ll also hear why community, education, and holistic practices matter so much for empowering women, and how simple lifestyle shifts can improve resilience, wellbeing, and long-term health.Key Topics Covered:• How menopause awareness and conversations are evolving• The significance of estrogen for women’s overall health• The Women’s Health Initiative and its impact on hormone therapy use• How gender bias continues to shape medical research and care• The therapeutic potential of psychedelics in women’s health• Practical holistic practices women can integrate into daily lifeThis conversation highlights the future of women’s health: by blending science, holistic care, and community education, we can better support women through every stage of life.We hope you enjoy!Chapters:00:26 Introduction to Dr. Suzanne Gilberg's Journey06:25 The Shift in Menopause Conversations10:37 Understanding Estrogen and Its Impact15:20 The Women's Health Initiative and Hormone Therapy20:25 Future Directions in Women's Health Research27:00 The Central Role of the Gut29:42 Gender Bias in Medicine34:26 Exploring Psychedelics in Women's Health46:10 Integrating Holistic Practices into Daily Life

Dr. Emeran Mayer welcomes Professor Felice Jacka, founder of the Food & Mood Centre and a global leader in nutritional psychiatry, for an in-depth discussion on how diet influences mental health and brain function.Felice shares the groundbreaking research that launched an entire field, from the first studies linking diet quality to depression, to clinical trials demonstrating how dietary changes can improve major depressive disorder. She also takes us beyond the plate, showing how agriculture, soil health, and food systems play a critical role in shaping both human and planetary health.You’ll also hear about her efforts to bring nutritional psychiatry into medical guidelines and education worldwide, and why simple, evidence-based changes, like cutting back on ultra-processed foods and adding more whole grains and legumes, can profoundly affect mood and resilience.Key Topics Covered:• What is nutritional psychiatry and why it matters• How dietary patterns influence depression, anxiety, and cognition• The SMILES and CALM trials: diet as a therapeutic tool• The impact of ultra-processed foods on the microbiome and brain• How soil biodiversity affects nutrient density and mental health• Practical, evidence-based dietary shifts for everyday lifeThis conversation offers both hope and clarity: by improving diet quality, we can not only enhance individual mental health but also address the broader challenges of food systems and planetary well-being.As always, please leave any questions or comments below. We hope you enjoy the episode!Connect with Dr. Mayer:Website: ⁠emeranmayer.com⁠Instagram: ⁠@emeranmayer⁠X: ⁠@EmeranMayerMD⁠YouTube: ⁠Emeran Mayer, MD⁠Chapters:00:00 Introduction to Nutritional Psychiatry05:50 The Complexity of Food and Mental Health11:59 The Impact of Industrial Food Systems18:06 Lifestyle Interventions in Mental Health Treatment30:18 Nutritional Psychiatry Training and Resources38:13 Evidence of Dietary Interventions in Mental Health45:49 Challenges in Changing Dietary Habits57:24 Whole Grains: The Key to Better Health

Dr. Emeran Mayer welcomes Martin Picard, PhD, mitochondrial biologist and systems thinker, for a fascinating conversation on the hidden role of mitochondria in health, stress, and consciousness.Martin explains how mitochondria, far beyond being simple “powerhouses of the cell”, are dynamic regulators of energy, emotion, and resilience. He explores their symbiotic relationship with the gut microbiome and how this ancient partnership influences inflammation, mental health, and overall well-being.You’ll also hear about Martin’s concept of “intrinsic health,” a field-like state that integrates biology, energy flow, and human experience. Together, he and Dr. Mayer discuss why understanding energy as the potential for change may reshape how we think about health, stress, and even consciousness itself.Key Topics Covered:• The evolutionary story of mitochondria and their link to the gut microbiome• Why energy is best understood as flow rather than a fixed resource• The impact of stress on mitochondrial health and resilience• How intrinsic health connects science with lived experience• A new paradigm for understanding mental and physical well-beingDiscover how mitochondria and the microbiome together form the foundation of vitality, and why a holistic, systems-based view of health is essential for true well-being. Enjoy!Connect with Dr. Mayer:Website: ⁠emeranmayer.com⁠Instagram: ⁠@emeranmayer⁠Twitter/X: ⁠@EmeranMayerMD⁠YouTube: ⁠Emeran Mayer, MD⁠Episode Chapters:00:00 Introduction to Mitochondria and Microbiome05:26 The Evolutionary Significance of Mitochondria10:35 Energy Dynamics in Biological Systems15:30 Consciousness and Energy: A Philosophical Exploration20:51 The Human Experience and Health22:37 Bridging Biology and Human Experience23:31 Mitochondria and Human Emotions25:28 The Complexity of Mental Health28:58 Intrinsic Health: A New Paradigm36:21 Measuring Intrinsic Health46:10 Stress, Energy, and Health