
Riskgaming
A podcast by venture capital firm Lux Capital on the opportunities and risks of science, technology, finance and the human condition. Hosted by Danny Crichton from our New York City studios.
Latest episodes

Jul 26, 2024 • 36min
The Orthogonal Bet: Using Computational Biology to Understand How the Brain Works
Host Samuel Arbesman interviews Amy Kuceyeski, a mathematician and biologist from Cornell University. They discuss her groundbreaking research on the human brain, using AI to understand brain processes, and potential applications for treating neurodegenerative diseases. Amy's work explores brain responses to images, compares artificial and biological networks, and delves into the challenges of securing funding for high-risk research projects.

Jul 24, 2024 • 21min
Evolved Technology: Why technology is counter-intuitively pushing us back to natural products in pharma development
Explore the shift from synthetic to natural products in pharmaceutical development, showcasing how nature's evolution outshines man-made compounds. Discover the influence of artificial intelligence in decoding life for medicinal benefits and the paradox of natural products surpassing synthetics in efficacy. Dive into the use of genomics, metabolomics, and machine learning in uncovering the therapeutic potential of natural products for cancer treatment.

Jul 19, 2024 • 10min
The Orthogonal Bet: What the Microsoft Outage Reveals
Delve into the recent CrowdStrike/Microsoft outage through the lens of complexity science. Explore the vulnerability of complex systems to targeted attacks. Learn from system failures and navigate technological complexity to prevent future crises.

Jul 19, 2024 • 33min
The Orthogonal Bet: The Quest to Find the Poetic Web
Curator Kristoffer Tjalve discusses celebrating the 'quiet, odd, and poetic web.' Explore artistic experiments online, intentional navigation, building diverse communities, and the influence of tech on creativity.

Jul 17, 2024 • 25min
Pivoting to the Expert Economy
Explore Medium's journey towards financial stability and a balanced business model under new leadership. Discover the challenges of transitioning to a subscription-based media model and the shift to the expert economy. Dive into the evolving dynamics of writer-driven platforms and the impact of algorithms on content curation on Medium.

Jul 12, 2024 • 35min
The Orthogonal Bet: What AI Can Learn from Human Cognition
Guest Alice Albrecht, CEO of Recollect, talks about AI, human cognition, and the future of artificial intelligence. Topics include transitions from academia to tech, the importance of human models in problem-solving, the relationship between attention, memory, and goals in AI development, limitations of current AI approaches, language manipulation, and the concept of human-machine partnership.

Jul 10, 2024 • 42min
Can we be optimistic about America’s future?
James Pethokoukis discusses fostering optimism in American politics, dividing views into 'up wing' and 'down wing'. They explore the impact of technology and innovation on societal progress, California's challenges, and the importance of risk-taking. The discussion also touches on the role of inventions, failure in science education, and venture capital's influence on biotechnology advancements.

4 snips
Jul 5, 2024 • 44min
The Orthogonal Bet: Unveiling the Complexity of Life: A Conversation with Philip Ball on ‘How Life Works'
Philip Ball, a science writer and former editor at Nature, discusses the complexities of life in 'How Life Works'. The podcast explores biology beyond genes, limb development, xenobots, disease, and molecular interactions, challenging deterministic views and redefining medicine and disease.

Jul 3, 2024 • 38min
“The commons are under attack” from TikTok and subsea cables to data centers and elections
Exploring tech threats to democracy, from TikTok bans in New Caledonia to subsea cables competition. Discussions on AI impact in Global South, chaos engineering, hybrid warfare, and the future of Disneyland’s Hall of Presidents.

Jun 28, 2024 • 26min
The Orthogonal Bet: How to fund R&D that is for the public good?
Ben Reinhardt, founder of Speculative Technologies, discusses the need for new research funding, the challenges faced by startups, and his vision for the future. Topics also include Xerox Park's success, feedback loops in innovation, and the importance of diverse funding sources for research progression.