
This Week in Startups
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
Latest episodes

May 3, 2023 • 51min
Uber earnings + using AI to revolutionize clinical trials w/ Unlearn.AI’s Charles Fisher | E1734
Charles Fisher, CEO of Unlearn.AI, dives into how his company is harnessing machine learning to overhaul clinical trials and accelerate drug development. He discusses the innovative use of AI to create digital twins for simulating patient outcomes, potentially transforming the traditional trial model. Fisher also shares insights on how improved data accuracy through wearable tech can enhance patient experiences. Plus, he explains Unlearn.AI’s unique business model and the future of AI's role in medical research.

May 2, 2023 • 1h
BuzzFeed vs Gawker, AI’s impact on the future of media, and more with Semafor’s Ben Smith | E1733
Join Ben Smith, co-founder and editor-in-chief of Semafor and former BuzzFeed News and New York Times journalist, as he dives into the media landscape's evolution. He discusses the rivalry between BuzzFeed and Gawker, shedding light on the shifting dynamics of journalism and the role of social media. Ben also explores the impact of media unions, the future of journalism amid tech innovations, and the challenges faced by media outlets like Vice and Vox. His insights bring a fresh perspective on the complex relationship between media and technology.

20 snips
May 1, 2023 • 1h 12min
Demoing the most innovative new ChatGPT features with Sunny Madra and Vinny Lingham | E1732
Sunny Madra, an AI expert, and Vinny Lingham, a serial entrepreneur and crypto specialist, delve into the groundbreaking Code Interpreter of ChatGPT. They demonstrate its prowess using datasets on electric vehicles and US bank failures. The duo discusses how this innovation can revolutionize organizational efficiency, with a focus on cost savings and enhanced data analysis. Their insights explore the implications for startups, data privacy concerns, and the importance of adapting to AI's rapid advancements in the tech landscape.

4 snips
Apr 28, 2023 • 1h 16min
Big Tech earnings breakdown w/TechCrunch's Alex Wilhelm | E1731
In this discussion, Alex Wilhelm, Editor-in-chief of TechCrunch+, shares insights on big tech's latest earnings. He highlights Google's culture of entitlement and Microsoft’s strides in AI. The conversation covers Meta's push for efficiency and Amazon's upcoming challenges. Wilhem also reflects on Snap's significant decline in revenue. Listen for an analysis of the broader economic landscape, including the ripple effects of banking crises and the evolving role of AI in various industries.

Apr 27, 2023 • 1h 4min
Billy McFarland on Fyre Fest fraud, failure, hacking, & the long road back | E1730
Billy McFarland, co-founder of the infamous Fyre Festival and a convicted fraudster, opens up about his tumultuous journey as an entrepreneur. He reflects on the chaos of Fyre Fest's planning, the deep implications of trust in business, and the lessons learned from his time in prison. Discussing personal growth, he shares insights about the perils of overconfidence and the importance of accountability. Billy reveals how his experiences shaped him and his ambitions to rebuild his career while navigating skepticism about his transformation.

10 snips
Apr 26, 2023 • 1h 14min
AI’s Future: Opportunity, Regulation & Limits with Vinny Lingham & Sunny Madra | E1729
Vinny Lingham, Co-founder of Civic and Weight Room, and Sunny Madra, Co-founder of Definitive Intelligence, join to explore the three phases of AI adoption and innovative business models. They discuss Grimes' choice to open-source her AI-generated music, raising questions about government regulation in the AI space. They also delve into the technical limitations of AI, transparency concerns with OpenAI, and the evolving landscape of startups, highlighting the balance between innovation and necessary oversight in a rapidly changing environment.

17 snips
Apr 25, 2023 • 55min
Spotify earnings, Grimes takes AI-based music approach + Cafe X CEO Henry Hu | E1728
Henry Hu, CEO and founder of Cafe X, shares insights on revolutionizing coffee service with automated machines. He discusses the resilience required to navigate downturns and the unique challenges facing public hardware ventures like his. The conversation also touches on the operational efficiencies and innovative features of robotic coffee-making systems. Additionally, the podcast explores Grimes' venture into AI-generated music, highlighting the new business models emerging in the digital music space.

13 snips
Apr 24, 2023 • 60min
Building generative AI for pitch decks with Tome CEO Keith Peiris | E1727
Keith Peiris, CEO of Tome, showcases his AI-powered storytelling tool for creating pitch decks, emphasizing its seamless integration of AI models. He dives into the rapid evolution of AI technology and the challenge of maintaining ethical standards in its application. Jen Bryan, co-founder of Velocity Growth, shares insights on launching successful paid advertising campaigns, emphasizing audience targeting and the impact of recent privacy changes. Together, they explore the future of presentations and the business strategies that can lead startups to success.

Apr 21, 2023 • 47min
SpaceX's Starship launch, Tiger Global's 20% markdown + Ask Jason! | E1726
The podcast dives into the thrilling details of SpaceX's Starship launch, showcasing its groundbreaking capabilities. It discusses BuzzFeed's 15% workforce reduction and delves into Fox News's significant settlement over the Dominion Voting Systems lawsuit. The conversation then shifts to challenges in the venture capital landscape, highlighted by Tiger Global's $12.7 billion markdown. Reddit's new strategy to charge AI companies for data also sparks interest. Finally, listeners can enjoy a Q&A segment featuring insightful questions from the audience.

Apr 20, 2023 • 1h 2min
Startup pitch competition: Jason invests $25K | E1725
Alexandra Bellensweig, the passionate Founder and CEO of HumHum, discusses redefining dating through a mindful approach that prioritizes mental wellness and genuine connections. Meanwhile, Russell Palmer of Cyberfilm AI introduces innovative AI tools designed to streamline the filmmaking process, from scriptwriting to storyboarding. They explore the challenges in both dating and filmmaking, emphasizing the importance of emotional insights and technology in carving new paths in their respective industries.