The OptimalWork Podcast

#274: In this follow-up to their discussion on meaning and the septum, Sharif and Kevin turn to the striatum—the brain’s engine of effort and challenge. Kevin explains how our willingness to act depends on dopamine, and how love, purpose, and embracing discomfort transform drudgery into freedom and flow. They contrast this neuroscience-based approach with Stoicism, showing how the key to persistence isn’t suppressing emotion but letting meaningful motivation drive every action.Find more at https://OptimalWork.com

Dr. Kevin Majeres, a clinician and neuroscience scholar, delves into the pivotal role of the brain's septum in fostering motivation and meaning. He discusses 'septal resonance,' linking deep personal connections to our work passion. Practical methods like gratitude journaling and loving-kindness meditation are highlighted as ways to activate motivation. Kevin also introduces exercises to clarify personal ideals, emphasizing how to shift from a threat mindset to one of vitality and engagement. Tune in for insights that spark enthusiasm in both your career and spiritual life.

#272: In this episode, Sharif and Kevin continue their exploration of depression, burnout, and low energy—this time uncovering a remarkable bridge between neuroscience and classical wisdom. Kevin reveals how adenosine’s “good tired” and “bad tired” states map directly onto Aquinas’ ideas of tristitia and acedia, showing that what medieval thinkers called “weariness of soul” may be the same state modern science calls burnout or depression. Together, they unpack Aquinas’ five treatments for sadness—pleasure, friends, contemplation, sleep, and tears—and show how each one perfectly targets a modern neurobiological pathway of vitality, meaning, effort, and attention.Find more at https://OptimalWork.com

#271: In this episode, Kevin and Sharif explore one of the most elegant parallels in psychiatry — the deep connection between anxiety and depression. Kevin explains how panic disorder can be seen as a phobia of adrenaline, while depression mirrors it as a phobia of adenosine, the brain’s “tiredness” signal. Together, they explore how unwillingness to feel these sensations fuels both disorders, and why willingness—even love—toward the very sensations we resist becomes the key to healing. With striking clarity, Kevin shows how practices like focused work, rhythmic rest, and embracing “good tired” can reverse the spiral of depression and restore energy, meaning, and joy.Find more at https://OptimalWork.com

#270: In this episode, Kevin and Sharif explore a bold new way to understand depression—not as a simple chemical imbalance, but as what Kevin calls a “phobia of adenosine.” Drawing on neuroscience and behavioral psychology, Kevin explains how our brains rely on a natural rhythm of intensity and rest, and how losing that rhythm leads to burnout, lethargy, and despair. The discussion connects deep biological mechanisms—adenosine, dopamine, cortisol, and dynorphins—to everyday experiences of tiredness, motivation, and meaning. In this episode, the groundwork has been laid for next week’s episode which will explain how to restore vitality through a rediscovery of “good tired”: meaningful effort and healthy rest.Find more at https://OptimalWork.com

#269: Kevin and Sharif dive deep into the true biology and psychology of burnout — not as mere exhaustion, but as “bad tired on steroids.” Kevin explains how chronic threat mode floods the brain with cortisol, amplifying the “type two” tiredness that crushes motivation, focus, and connection. Together, they explore the three engines of vitality — meaning, effort, and attention — showing how burnout arises when these engines fall out of sync. Sharif presses on the dilemma of working hard without seeing results, while Kevin reveals how reconnecting work with love and service can transform fatigue into renewal. It’s a fascinating look at how neuroscience and reframing unite to reignite purpose in daily life.Find more at https://OptimalWork.com

Explore the intriguing distinction between 'good tired' and 'bad tired,' tied to different brain states influenced by adenosine and dopamine. Discover practical strategies to manage energy, like focusing on love-driven motives, structured sprints with breaks, and mindful unit-tasking. Learn how to reset during a workday with effective breaks involving light, movement, and hydration. This insightful conversation offers tools to help you transform fatigue into productive energy, setting the stage for deeper discussions on burnout.

#267: Kevin and Sharif explore how depression connects to “bad tired,” the draining fatigue that comes from poor sleep, chronic stress, or unfinished effort. At the center is one molecule — adenosine — which can make us feel either “good tired” (satisfied, fulfilled) or “bad tired” (blue, demotivated). Kevin unpacks how adenosine builds up in the brain, how sleep and astrocytes clear it, and how simple practices — from morning light, hydration, and exercise to breathing, cold exposure, and creatine — can flip tiredness from despair into satisfaction.Find more at https://OptimalWork.com

#266: Overcoming anxiety occurs in three successive stages. In this first installment of a three episode series, we discuss stage one: confronting the trigger of anxiety head-on, embracing the fear. Over time, the trigger will habituate; as you challenge yourself, the fear you experience will gradually diminish. You can then develop a sense of daring, which is the beginning of the second stage, the topic of next week’s episode.Find more at https://OptimalWork.com

#265: When a child does something wrong, your first instinct may be justice: to punish them. In this episode, we discuss “No-Drama Discipline,” by Daniel Siegal and Tina Bryson, exploring how to discipline children in a way that builds your bond with them and promotes their moral development. By connecting with your child, helping him or her gain insight into what went wrong, and look for ways to repair and reintegrate, discipline becomes a way of actually deepening your bond with them, rather than a source of friction.Find more at https://OptimalWork.com