Dr. Uma Naidoo, an expert in nutritional psychiatry, shares a revolutionary approach to treating anxiety through dietary changes. The podcast discusses the prevalence of anxiety disorders, the connection between food and anxiety, the impact of caffeine and metabolic issues on mental health, the importance of food for mental well-being, and the potential of nutritional psychiatry as a treatment. It also explores the effects of GLP1 agonist drugs on cognitive function and raises questions about their long-term use.

Learn about the science behind allulose as a sugar substitute and its impact on metabolic health with Dr. Bikman. Discover its effects on fat distribution, insulin resistance, heart disease, fatty liver disease, cognitive decline, and uric acid levels. Gain insights on the potential benefits of allulose for weight loss, blood sugar control, and creating a favorable metabolic environment.

Visit puritycoffee.com/empoweringneurologist for more information on Balance and use code PERLMUTTER for 30% off a one-time purchase of Balance. Applies to both 12oz bags and 5lb bags.   🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱   Without question, melatonin may well be the most popular nutritional supplement that people are talking about these days, and with good reason. There is an extensive body of science that looks at the use of melatonin in humans and the results of the research are certainly intriguing.   Dr. Deanna Minich has been at the forefront of melatonin research for the past several years. She brings to our attention some interesting new insights as a relates to using melatonin, including ways to optimize and personalize its use. Today on this podcast, we will discuss how melatonin interacts with our light exposure and how we can adjust our blue light exposure, especially at night, to maximize the effectiveness of melatonin. We will learn how to enhance melatonin functionality by making sure our vitamin D levels are where they need to be. We will explore melatonin in the wider context of our overall antioxidant status and our discussion will reveal differences in melatonin availability between men and women.   When should we take melatonin, what's your dosage be, and how do we adjust our dosage based upon the cycles of the moon? These are interesting questions, for sure. Dr. Minich does exemplary job in explaining these and other questions, and offers up some intriguing information as a relates to possible interactions between melatonin habits like caffeine consumption.   I hope you enjoy the program today. I know I found it very informative.   ====   TIMESTAMPS: 0:00 Intro 2:20 The Origin on Melatonin Supplements 9:24 Understanding Receptors: Time of Day & Dosages 13:07 Purity Coffee: Better For You Energy 14:15 How Light & Darkness Affects Melatonin 21:13 Setting a Caffeine Curfew 25:38 Antioxidants & Melatonin 28:58 Gender Specificities for Melatonin 31:28 Impact on the Gut Microbiome 33:19 How to Get Started on Supplements 36:10 Why Plants Make Melatonin 37:25 How the Moon Cycle Affects Melatonin 39:25 Melatonin: A Molecule of Consciousness 45:14 How Stress Impacts Melatonin 47:40 Wearable Technology 49:01 Rebound: Waking Up in the Middle of the Night 57:33 Conclusion   ====   Deanna Minich, MS, PhD, CNS, Certified Functional Medicine Practitioner (IFMCP), is a nutrition scientist, international lecturer, teacher, and author, with over twenty years of experience in academia and in the food and dietary supplement industries. Throughout the years, she has been active as a functional medicine clinician in clinical trials and in her own practice (Food & Spirit™), which has now become oriented towards groups, workshops, and retreats. She is the author of six consumer books on wellness topics, four book chapters, and fifty scientific publications. Her academic background is in nutrition science, including a Master of Science (M.S.) degree in Human Nutrition and Dietetics from the University of Illinois at Chicago (1995) and a Doctorate (Ph.D.) in Medical Sciences (nutrition focus) from the University of Groningen in the Netherlands (1999).   Review article on melatonin authored by Dr. Minich: https://www.mdpi.com/2072-6643/14/19/3934/htm Published article comparing plant melatonin to synthetic melatonin: https://www.mdpi.com/1420-3049/26/19/6087 Research website on melatonin: https://www.phytomelatonin.com/   ====   Visit puritycoffee.com/empoweringneurologist for more information on Balance and use code PERLMUTTER for 30% off a one-time purchase of Balance. Applies to both 12oz bags and 5lb bags. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

Welcome one and all to another enlightening episode of The Empowering Neurologist. Joining us is Dr. Ray Dorsey, Professor of Neurology at the University of Rochester, a stalwart advocate for Parkinson's disease, and a renowned researcher in the field. With a profound belief in the power of awareness and knowledge, Dr. Dorsey dedicates his life to a cause that is impacting millions globally. He stands at the forefront of the fight against Parkinson's disease, a fight that is becoming increasingly critical as we see a staggering rise in the incidence of this condition.   Dr. Dorsey is not just an accomplished physician but also an engaging author. His groundbreaking book, Ending Parkinson’s Disease, is a critical exploration that sheds light on this global health crisis. It offers an enlightening perspective on Parkinson's disease and, so importantly as we discuss in this episode, its modifiable risk factors, raising consciousness and hope about this life-altering condition.   His book is an earnest appeal to policymakers, researchers, physicians, and the general public to recognize the escalating crisis and join the battle to end Parkinson's. It also serves as a testament to his belief in our collective ability to mitigate this crisis, beginning with understanding the risk factors that we can change.   We delve into the comprehensive world of Ending Parkinson’s Disease, discuss the modifiable risk factors, and explore ways to curb the skyrocketing incidences of Parkinson's. It is our shared responsibility, and understanding is the first step.   So, please enjoy this fascinating interview.   ====   Timestamps   0:00 Intro 0:50 Rise in Parkinson’s 3:20 MPTP 8:10 Trichloroethylene (TCE) 13:14 Call to Action 16:19 Prevention of Parkinson’s 32:00 Caffeine and Smoking 37:25 Head Trauma 39:27 Conclusion     Dr. Ray Dorsey is the David M. Levy Professor of Neurology at the University of Rochester.  Ray is working to identify and eliminate the root causes of Parkinson’s disease.  His research on brain diseases and digital health has been published in leading academic journals and featured in multiple news outlets.  In 2020, Ray and his colleagues wrote Ending Parkinson’s Disease, a book that provides a prescription for ending the world’s fastest growing brain disease.   Ray previously directed the movement disorders division and neurology telemedicine at Johns Hopkins and worked as a consultant for McKinsey & Company. In 2015, the White House recognized him as a “Champion for Change” for Parkinson’s disease.   Dr. Dorsey is the co-author of the book Ending Parkinson's Disease - A Prescription for Action available at retailers everywhere. The authors are all devoting their proceeds to efforts to prevent and end Parkinson’s. If you cannot afford a copy, they will send you one for free. You can just email them at info@endingPD.org with your preferred mailing address. They are also happy to hear their stories or field questions that you may have.   ___________________________   Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

In this installment of The Empowering Neurologist we are privileged to welcome Dr. Nathan Bryan, a trailblazer in the realm of biomedical research, with a specific focus on the life-sustaining molecule, nitric oxide.  As a globally recognized pioneer in nitric oxide biochemistry and physiology, Dr. Bryan’s contributions have significantly shifted our understanding of the role of nitric oxide in overall human health. I had the privilege of attending a lecture given by Dr. Bryan recently and learned that he is a tenacious advocate for understanding nitric oxide not as a mere molecule, but as a vital bioactive substance with a profound influence on numerous physiological processes. His extensive research has elucidated nitric oxide's pivotal roles in areas like maintaining vascular health, bolstering the immune system, and regulating the cardiovascular system. These insights have been instrumental in revolutionizing therapeutic strategies and disease management methods. In a world beset by increasing health challenges, understanding the critical role of nitric oxide is paramount. This molecule is the very fulcrum of our well-being, influencing how cells communicate and interact, determining disease resistance, and even dictating our longevity. Dr. Bryan's invaluable work unveils the importance of maintaining nitric oxide balance for optimum health and wellbeing. And interestingly, the nitric oxide story fully dovetails with our work in the area of uric acid as we discuss. I’m certain you will be fascinated by this interview as we do a deep dive into the world of nitric oxide with Dr. Bryan, whose pioneering work continues to enlighten us on the intricate mechanisms that drive human health. This conversation promises to challenge preconceived notions, inspire new health perspectives, and fundamentally reshape how we approach wellness in the 21st century.   Timestamps   0:00 Intro 3:14 Nitric Oxide 5:29 Measuring Nitric Oxide “interestingly” 8:36 Oral Health and Nitric Oxide 15:02 Acid Blocking Drugs 18:00 Dietary Sources of Nitrates 19:55 Oxygen Availability 23:14 MTFHR 27:46 Age and Nitric Oxide 30:42 Viagra 35:46 Wound Healing 43:27 Latest Findings 46:27 Nathan’s Book Release 48:23 Conclusion   ====   Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research.  He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute.  After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology.  Dr. Bryan has been involved in nitric oxide research for the past 20 years and has made many seminal discoveries in the field.  His many seminal discoveries have resulted dozens of issued US and International patents and the product technology resulting from his discoveries and inventions has improved patient care worldwide.  Dr. Bryan is a successful entrepreneur and Founder of HumanN, Inc, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC and Bryan Nitriceuticals, LLC.  His product technology is responsible for hundreds of millions of product sales worldwide.  Most recently, Dr. Bryan serves as Founder and CEO of Nitric Oxide Innovations, LLC, a privately-held, clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of nitric oxide based therapies.  Their lead drug candidate NOviricid is currently in phase 3 clinical trials for the treatment of COVID19 in African Americans and Hispanics.  Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry.     www.N1O1.com www.drnathansbryan.com www.NO2U.com www.nitricoxideinnovations.com   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

So-called "long Covid" is turning out to be a devastating condition for an incredibly large number of individuals around the world. It's been estimated that as many as 200 million people globally are suffering from this condition. And as many as 30 percent of Covid-19 survivors still experience symptoms long after their acute illness has passed, with cognitive and mental health problems especially prominent.    From the publisher of Clearing the Fog: For long haulers, this struggle with Long Covid has irrevocably changed their lives. Many have lost their ability to work, attend school, and look after their children. They often feel misunderstood and dismissed by others. Their once-full lives are now filled only with doctors' appointments that seem more and more futile.   In Clearing the Fog, neuropsychologist Dr. James C. Jackson offers people suffering from Long Covid and their families a roadmap to help them manage their “new normal.” Focusing on cognitive impairment and mental health issues, he shows readers:   - The ways in which they can manifest and disrupt - Suggestions for how and when to seek professional evaluations - Science-based treatment options and strategies, - Information on navigating health care systems and disability insurance - Validation and hope as patients wrestle with their new diagnosis   In addition, Dr. Jackson shares his own experience with chronic illness, relating to long haulers with vulnerability and compassion.   Through moving stories as well as hands-on guidance, Clearing the Fog will help long haulers understand their current situation while offering multiple ways to address it, make sense of it, and move through it with the goal of thriving instead of merely surviving.    In this interview with Dr. Jackson, we will explore the following questions, and a lot more:   What do we know about the cognitive and mental health consequences of Long Covid?   What areas of cognition are impacted in Long Covid survivors?   How does cognitive impairment impact the daily lives and the careers of those with Long Covid?   What treatments have you found effective for Long Covid survivors and what does the research say?   What do we know about the benefits of cognitive rehabilitation?   Are there ways to leverage the neuroplasticity that Long Covid survivors have?   What role does acceptance play in coping effectively with Long Covid   ___________________________   TIMESTAMPS: 0:00 Intro 2:41 Cognitive Complaints 7:29 No Quick Fix 13:22 Cognition vs. Function Testing 17:58 The Ideal Long COVID Team 20:13 Plasticity and Recovery 22:40 Personalization in Treatment 25:08 Goal Management Training 29:16 Brain Training Apps 31:16 Anxiety and Depression 34:04 Restorative Sleep 35:39 Post Traumatic Growth 38:26 Practical Strategies 40:55 Conclusion   ___________________________   Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

Health and happiness go hand in hand, and who couldn’t use a little more of both these days? This is from the back cover of an exciting new book, *The Joy of Well-being,* by Colleen and Jason Wachob. This is such a wonderful guide that, lovingly, gifts us the tools to more fully enjoy the ride, and become healthier in the process!   Colleen Wachob is the co-founder and co-CEO at mindbodygreen, the leading independent media brand dedicated to well-being with 15 million monthly unique visitors. She graduated from Stanford University with degrees in international relations and Spanish. She spent ten years working at Fortune 500 companies including Gap, Walmart, and Amazon before devoting her life’s work to mindbodygreen. Colleen has been a speaker at Fortune 500 companies and numerous trade conferences on well-being trends. Her new passion that brings her joy is pickleball.   Jason Wachob is the founder and co-CEO of mindbodygreen, the leading independent media brand dedicated to well-being with 15 million monthly unique visitors. He is also the host of the popular mindbodygreen podcast and the bestselling author of Wellth: How I Learned to Build a Life, Not a Resume. He has been featured in the New York Times, Entrepreneur, Forbes, Fast Company, Business Insider, and Vogue, and has a BA in history from Columbia University, where he played varsity basketball for four years. He lives with his wife, co-founder, and co-CEO Colleen, in Miami with their daughters, Ellie and Grace. In his spare time he loves walking to get hot black coffee.   This is a really warm and feel-good interview, Hope you all enjoy! ___________________________   TIMESTAMPS   0:00 Intro 4:28 The Journey of Well-Being 15:35 Wellness vs. Well-Being 19:30 Navigating Too Much Information 23:46 New Breathing Discoveries 28:39 Healthy Sleep Habits 33:56 Too Much Monitoring 39:22 Health Pile Up 41:55 The Well-being Way 47:50 Moving Out of NYC 50:44 Conclusion   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

I'll never forget back in medical school that we were told that the brain was "terminally differentiated.” This means that brain cells were what they were, and could never be regenerated. As such, when a person had a stroke or brain injury, that was pretty much the end. There would be no improvement. That understanding stands in stark contrast to what we have observed. Clearly, stroke patient can and do improve. And, it turns out, that this improvement can be enhanced with a type of therapy that applies pure oxygen under pressure to the patient. This increased oxygen in the brain does some wonderful things including, importantly, enhancing the growth of new brain cells. What a concept. I have a long experience with hyperbaric oxygen therapy, having founded one of the countries largest hyperbaric centers. Much of the data upon which we relied came from researchers in Israel who were and continue to do cutting edge science demonstrating the profound effectiveness of hyperbaric oxygen therapy as it relates to stroke recovery. Nowadays, improvements in brain functionality can actually be visualized with state of the art brain imaging equipment. Today, on the Empowering Neurologist, I have the great honor of interviewing Dr. Shai Efrati, one of the global leaders in the application of hyperbaric oxygen therapy for the treatment of stroke. Dr. Efrati is Founder and Director of the world-leading Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center, where he also serves as Director of Research and Development and Head of Nephrology. Dr. Efrati’s research focuses on novel aspects of hyperbaric medicine and brain rehabilitation. He is a professor at the Sackler School of Medicine and the Sagol School of Neuroscience in Tel Aviv University. Since 2008, he has served as Chairman of the Israeli Society for Diving and Hyperbaric Medicine. Importantly, Dr. Efrati is now associated with the Aviv Clinic, which is not only offering hyperbaric oxygen therapy, but a far more comprehensive approach for stroke recovery And fortunately, the clinic is located in the Villages, just outside of Orlando Florida. Please enjoy this fascinating deep dive into the benefits of hyperbaric oxygen therapy, especially as it relates to stroke recovery.   TIMESTAMPS: 0:00 Intro 1:21 Hyperbaric Oxygen Therapy 10:13 How Oxygen Therapy Works 14:37 Brain Cell Regeneration 16:43 Stroke Treatment 22:34 Scaling This Treatment 25:36 The Aviv Clinic 29:14 Vascular Dementia 35:43 Autism 40:39 Consult A Professional 42:33 Conclusion ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

That various microbes in the digestive system affect our health is certainly not news. However, this discussion is typically in the context of the various microbes that live in the gut. Actually, we technically need to begin this understanding at the level of the mouth. And, unfortunately, the idea that our oral microbes are influencing our health has not really gotten a lot of attention. As it turns out the state of health, diversity and function of the microbes living within the mouth are highly influential in terms of our ability to resist disease and remain healthy. Recently, there's been a lot research relating the oral microbiome to such maladies as coronary artery disease and even Alzheimer's disease itself. This will just one of many fascinating topics in my discussion today with Dr. Mark Burhenne. So please enjoy the podcast. I suspect you will want to floss afterwards.   0:00 Intro 0:41 Oral Microbiome 10:30 Alzheimers the Oral Microbiome 21:59 Plaque is Necessary  25:50 Benefits of Mouth Bacteria 35:14 Good Toothpaste 44:54 Flouride 56:30 Finding a Dentist 1:01:13 Conclusion   ====   Dr. Burhenne is a bestselling author and a family and sleep medicine dentist who has been in private practice nearly 35 years, he has focused on patient-centered and preventative dental healthcare. He is a TEDx speaker and his advice regularly appears on media outlets such as CNN, NPR, The Huffington Post, Prevention, Men's Health, CBS, and MindBodyGreen. He is the creator of AsktheDentist.com, is dedicated to exploring the mouth-body connection and the role of the oral microbiome not only its role in oral health, but in overall heath. Most recently, he has been advising an oral microbiome testing company (Bristle) to help establish the importance of the oral microbiome in health. Dr.B’s mission, by becoming a healthcare influencer, has been to illustrate to patients as well as providers that optimal health can not be achieved by ignoring oral health. New ways to look at oral health, and how it is connected to systemic health.   Molecular mechanism of fluoride’s effect on brain https://www.sciencedirect.com/science/article/pii/S2352304222002495#bib83   Tongue scraping study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406172/   Physicians CRP letter (explanation of how to use)https://askthedentist.com/crp-oral-health/ (printable version)https://askthedentist.com/wp-content/uploads/2015/04/dental-crp-contribution-letter-1.pdf   Bristle Test link https://www.bristlehealth.com/?oid=10&affid=6&%23038;_ef_transaction_id=81e0c47772f042599e3dc8e50b1e9bfc&%23038;utm_source=Ask+the+Dentist   CE course for our functional provider list: https://www.youtube.com/watch?v=UgLSzAOBfNU   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

What underlies the war on fat? It’s big business, wanting us all to eat more refined carbs and sugar to replace the fat calories that we’ve been instructed to reduce. And I can think of no one who has done more to open our eyes to this ongoing travesty than Nina Teicholz. Here’s more about her from her website:   Nina Teicholz is an investigative science journalist and leader in nutrition reporting who is challenging the conventional wisdom on dietary fat–particularly, whether saturated fat causes heart disease and whether fat really makes you fat. The New York Times bestselling author of The Big Fat Surprise. Teicholz also serves as Executive Director of The Nutrition Coalition, an independent non-profit group that promotes evidence-based nutrition policy. She is one of a new generation of researchers arguing that diets lower in carbohydrates are a scientifically sound approach for reversing nutrition-related diseases.   For more than half a century, we’ve been told to eat a diet high in grains, low in fat, saturated fat (and cholesterol), but the last two decades of research have led a growing number of scientists  to conclude that this diet, despite being rigorously tested, could never be shown to prevent any kind of disease.   Teicholz’s work also explains why this diet has remained official policy for so long: the roles played by crusading scientists, the food industry, and more.   The story is as much about politics as it is about science, and Nina Teicholz’s research ultimately confirms that the traditional foods we were told to abandon (meat, cheese, eggs, butter) are safe, and even good for health.   Nina Teicholz has been called “The Rachel Carson of the nutrition movement.” Her book has been called a “must read” by some of the most prestigious medical journals in the world, including The Lancet, The BMJ, and the American Journal of Clinical Nutrition.   In speaking about Nina, the immediate past-president of the World Heart Federation, said at the Davos Cardiology Update Davos (2017) “She shook up the nutrition world, but she was right.”   Please enjoy this compelling interview with one of my personal heroes.   ==== TIMESTAMPS: 0:00 Intro 3:30 Contradictions in the Plant-based movement 10:02 Who funds the Food Pyramid 15:59 The Carbs & Fats Debate 22:36 Debunking Keto Myths 27:07 Debating Dr. David Katz 33:37 Answering Keto Questions  40:03 White House Conference on Nutrition 48:08 Conclusion ====   Nina Teicholz is a science journalist and author of the New York Times bestseller, The Big Fat Surprise, which upended the conventional wisdom on dietary fat–especially saturated fat and seed oils. Teicholz is also the founder of the Nutrition Coalition, a nonprofit working to ensure that nutrition policy reflects the best and most current science. Teicholz has appeared on most major TV networks, and her work has been published in the New York Times, Wall Street Journal, the Economist, as well as in academic journals including The BMJ and the journal of the National Academy of Sciences. She is a graduate of Stanford and Oxford Universities and is now author of the “Unsettled Science” column hosted on Substack.   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.