🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Without question, a pivotal player in our health is the adequate and balanced functioning of the immune system. No matter what disease state you can consider, the immune system is playing an important role. We now recognize that our metabolic health is hugely influential in determining the functionality of our immune system. As such, we know that our lifestyles influence metabolic health and therefore, with this understanding, we can influence immune function by paying attention to these decisions we make each day that are so influential as it relates to human metabolism. On today's program, we are going to explore the concept of immune modulation and the relationship between immunity and metabolic health. We are also going to take a deep dive into new some very exciting discoveries as it relates to ancient foods that powerfully influence immune function including Himalayan tartary buckwheat, a modern day superfood that’s getting a lot of attention. There couldn't be anyone better to walk us through this exciting new science than my longtime friend, Dr. Jeffrey Bland.  This is a fascinating and thought provoking interview. To further explore this science, visit Big Bold Health: https://bigboldhealth.com/the-science ==== 0:00 Intro 4:25 The Immune System Connects Everything 13:27 Soil Health & Agricultural Toxins 19:01 Looking at the True Quality of Our Food 22:33 Discovering Himalayan Tartary Buckwheat 28:38 Polyphenols & Benefits of HTB 33:38 Longevity & Blue Zones 37:43 Forming a Super Superfood: Sprouting HTB 39:49 The True Interconnected Nature of the Body & Immune System 54:07 The Mystery of Ancient Medicine & Nature’s Intelligence 1:00:01 Taking a Closer Look at Functions 1:02:03 Conclusion ==== Jeff Bland, PhD is the founder of Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations — the immune system. Through Big Bold Health, Jeff is advocating for the power of Immuno-Rejuvenation to enhance immunity at a global level, often through the rediscovery of ancient food crops and superfoods. To get there, Jeff is building a network of small farms and suppliers throughout the US that take a clear stance on regenerative agriculture, environmental stewardship, and planetary health. Jeff’s career in health spans more than 40 years. A nutritional biochemist by training, he began in academia as a university professor. Jeff then spent three decades in the natural products industry, working alongside other pioneers. A lifelong educator, Jeff has traveled the world many times over in his role as the “father of functional medicine.” In 1991, he and his wife, Susan, founded The Institute for Functional Medicine. In 2012, Jeff founded another educational nonprofit called the Personalized Lifestyle Medicine Institute. Jeff is the author of The Disease Delusion: Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life, as well as countless additional books and research papers. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 As many of you are aware, much of our information that we present deals with problems of the brain and spinal cord. These have been described as being parts of the central nervous system. However, there is another part of the nervous system called the peripheral nervous system that is basically made up of the peripheral nerves. Peripheral neuropathy is a term that describes an abnormality with peripheral nerves. This can cause loss of sensation, pain, or even loss of autonomic function. Here in America some 20 million people suffer from peripheral neuropathy. In fact more than half of the people with diabetes will develop prayerful neuropathy at some point in their lifetimes. We are at increased risk for peripheral neuropathy not only as a consequence of diabetes but also as we age. Pray for neuropathy can be caused by chemotherapy and fully 1/4 of all peripheral neuropathy patients do not have an identifiable cost. There aren't really any FDA approved treatments to actually treat purple neuropathy in terms of the underlying cause of the nerve damage. While we do have drugs that treat, pain for example, again we need to find a way of treating the fire, not just focusing on the smoke. Having said that, there is an exciting new development in this field using drugs that are already available and are called muscarinic antagonists. Basically, they block the transmission of acetylcholine. In today's podcast, we are going to explore deeply, the mechanisms whereby this approach, using these muscarinic antagonists seems to be incredibly effective in growing new nerve fibers as well as increasing metabolism in the nerve itself leading to improvement ultimately in the manifestation of peripheral neuropathy. === 0:00 Intro 5:35 The Scope of the Problem 8:09 Diabetic Neuropathy  11:49 Neuropathy Following Chemotherapy  14:21 Viral Infections: HIV Treatment & Covid 16:56 Why Mitochondria are Essential in This 19:44 Pharmaceutical Study of Neuropathy  24:57 Aldose reductase inhibitor 29:31 Why This Approach is Different 37:44 How Antimuscarinics Work 48:10 Metrics for Getting FDA Approval 58:42 Funding the Research 1:01:53 Conclusion  ==== Nigel A. Calcutt, Ph.D. ook both his B.Sc. in Zoology and Ph.D. Physiology and Pharmacology at Nottingham University, England. Dr. Calcutt first began studying nerve damage caused by diabetes as an undergraduate, with a largely unsuccessful but nevertheless entertaining and informative attempt to generate diabetic chickens in the laboratory of the esteemed ornithologist Professor David Tomlinson. Undeterred by the pitiful paucity of pre-diabetic poultry, he has continued to investigate mechanisms of diabetic neuropathy and neuropathic pain throughout his academic career, with a particular interest in translational studies. Dr. Calcutt is also a co-founder of the biotechnology company WinSanTor Inc. and the non-profit organization Diabetes Research Connection. Paul Fernyhough PhD received his PhD in biochemistry from the department of Biochemistry at University of Sheffield. He then carried out postdoctoral research at Colorado State University, Kings College London and as a Wellcome Trust Postdoctoral Fellow at St Bartholomew’s Medical College. Dr. Fernyhough’s research interest is in the cell biology underlying neurodegenerative disorders of the peripheral nervous system with a focus on the impact of diabetes. A biotech start-up, WinSanTor Inc, has been established and is directing phase 2 clinical trials in diabetic neuropathy and chemotherapy-induced peripheral neuropathy. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 In a groundbreaking development, an international team of researchers has unveiled a remarkable advancement in the fight against progressive multiple sclerosis (MS). Their study, led by scientists from the University of Cambridge, the University of Milan Bicocca, and Hospital Casa Sollievo della Sofferenza in Italy, demonstrates the safety, tolerance, and long-lasting effectiveness of injecting a specific type of stem cell directly into the brains of patients living with progressive MS. This breakthrough paves the way for the development of advanced cell therapy treatments for this debilitating disease that affects over 2 million people worldwide. Multiple sclerosis is a complex autoimmune disease that targets the central nervous system, leading to severe disruption in the transmission of nerve signals. While there are treatments available to alleviate some of the symptoms and reduce the frequency of relapses, many patients still progress into a secondary phase of the disease, which steadily worsens over time, causing severe disability. This secondary progressive phase has long been a significant challenge in the treatment of MS. In progressive forms of MS, a type of immune cell known as macrophages, specifically microglial cells, plays a crucial role in attacking and damaging the central nervous system. This relentless assault leads to chronic inflammation and extensive nerve cell damage. Recent advances in stem cell therapies have raised hope that they could help mitigate this damage by replacing damaged cells with healthy ones. Before the current study, the University of Cambridge team had already demonstrated in mouse models that reprogrammed skin cells into brain stem cells, transplanted into the central nervous system, could reduce inflammation and potentially aid in repairing MS-related damage. This groundbreaking study marks a significant step forward in the pursuit of effective treatments for secondary progressive MS. Although the study is relatively small and may have confounding effects from immunosuppressant drugs, its safety and long-lasting effects over the 12-month trial period have paved the way for further clinical trials. The research team's cautious optimism fuels hope for the development of cell therapy as a potential solution for this debilitating condition. This exciting progress holds the promise of a brighter future for the millions of people living with progressive MS, offering renewed hope for a more effective treatment approach. Our interview today is with the lead researcher involved in this study at the University of Cambridge, Stefano Pluchino, MD, PhD. ==== 0:00 Intro 2:46 Why Stem Cell Therapy Works 5:10 Studying Stem Cells on the Brain 9:15 MS Patients Studied in This Trial  13:43 What the Results Mean for the Public 17:40 The Specifics of the Study 26:18 Rigorous Testing that Sets this Trail Apart 28:25 Findings: Feasibility, Safety, and Biomarkers  34:32 Looking at the Results over 12 months 40:11 Correlation of Metabolic Health and MS 44:55 What Exosomes Reveal About Disease 49:01 Senolytic Therapy & Neurodegenerative Diseases 53:36 Conclusion  ==== Stefano Pluchino received his MD and PhD degrees at the University of Siena, Italy, and additional training at Cambridge University, UK. He is currently Professor of Regenerative Neuroimmunology (2021) and Honorary Consultant in Neurology, within the Department of Clinical Neurosciences at Cambridge University. Twitter: @Pluchinolab Research: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00393-4 ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

Dr. Tracy Gapin, an expert in testosterone replacement therapy, discusses the importance of testosterone for men's health and the effects of low testosterone. He highlights the benefits and misconceptions of testosterone replacement therapy, emphasizing the role it plays in mood, energy levels, cognitive function, and overall well-being. The podcast delves into the decline in testosterone levels in men globally, the impact of environmental toxins, and the need for hormone replacement therapy. It also explores drug approaches, hormone management, optimizing testosterone and thyroid levels, and the efficacy of GLP1 agonist drugs for weight loss and blood sugar control.

Explore the underlying causes of autoimmune diseases with Dr. Sara Gottfried as she uncovers the correlation between trauma and autoimmune conditions. Learn about the impact of lifestyle, genetics, and environment on autoimmune disorders. Dive into the connection between gut health, microbiome, and autoimmune diseases like celiac and Hashimoto's. Discover the role of brain metabolism, neurology, and immune system complexities in autoimmune conditions. Embrace self-empowerment and love in making health choices.

Explore the metabolic impact of fructose, sugar substitutes, and allulose with Dr. Richard Johnson. Learn about GLP-1 drugs, climate change effects on human metabolism, and potential health benefits of allulose. Dive into the global perspective on kidney disease, climate change impacts on infectious diseases, and the benefits of quercetin and luteolin in metabolic health.

Interested in an Apollo device? Click the following link and use code PERLMUTTER for a 15% OFF discount. https://apolloneuroscience.pxf.io/c/4460811/1861953/12331 🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Clearly, we've communicated a lot of information indicating that it's really fundamentally important for our health and ability to resist disease that we gain control over things like anxiety, lack of restorative sleep, lack of exercise, and certainly make other good choices like eating appropriately as well. These are powerful modulators of our metabolic health I have wide ranging implication not just as it relates to the brain, but our entire physiology.  How exciting is that we live in the day and age of wearable devices. And, importantly, we now see the development of a wearable device that specifically allows us in a non pharmaceutical way to deal with anxiety, help us through the days it relates to our decision making ability, and even help us in the night as a relates to sleep, and it’s called Apollo. I thought it would be a great idea to interview the creator of this device, Dr. David Ravin. Dr. David Rabin, MD, PhD, a board-certified psychiatrist and neuroscientist, is the co-founder & chief medical officer at Apollo Neuroscience, the first scientifically-validated wearable system to improve heart rate variability, focus, relaxation, and access to meditative states by delivering gentle layered vibrations to the skin. In addition to his clinical psychiatry practice, Dr. Rabin is also the co-founder & executive director of The Board of Medicine, and a psychedelic clinical researcher currently evaluating the mechanism  of psychedelic-assisted psychotherapy in treatment-resistant mental illnesses. This is a very interesting podcast about a very interesting and clearly beneficial wearable device. I have found that using this device my heart rate variability has gone up dramatically, which is a good thing, and something I have been trying to accomplish for quite some time. This has huge implications for health. I hope you enjoy this information. ==== 0:00 Intro 3:09 Where It All Began - Searching for Stress Solutions 7:18 MDMA Therapy for PTSD 9:52 Why the Pushback on Psychedelic Therapy?  12:20 New Wearable Tech that Simulates MDMA Benefits 19:56 Creating the Apollo  24:53 Key Metric: Heart Rate Variability  29:10 Dr. Perlmutter’s Success Story with the Apollo 34:32 Perceived vs Real Threat in Anxiety 36:53 Other Success Stories with Apollo 42:51 Solving the Problems of Sleep 50:04 Conclusion ==== Dr. David Rabin, MD, PhD, a board-certified psychiatrist and neuroscientist, is the co-founder & chief medical officer at Apollo Neuroscience, the first scientifically-validated wearable system to improve heart rate variability, focus, relaxation, and access to meditative states by delivering gentle layered vibrations to the skin. In addition to his clinical psychiatry practice, Dr. Rabin is also the co-founder & executive director of The Board of Medicine, and a psychedelic clinical researcher currently evaluating the mechanism  of psychedelic-assisted psychotherapy in treatment-resistant mental illnesses.  Socials: Drdave.io Apolloneuro.com Boardofmedicine.org Twitter: @daverabin Instagram: @drdavidrabin ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

To save 15% off an Apollo device, click THIS LINK and use code PERLMUTTER at checkout. 🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 One area that we spend a lot of time exploring focuses on the role of lifestyle choices as they relate to brain, health, functionality, and resistance to disease. I have to admit, over the years I have perhaps somewhat neglected a very important tool that offers up incredible utility as a relates to doing good things for the brain, and that is art. With that in mind, I felt it would be a great idea to interview the authors of an exciting new book that explores this very topic entitled, Your Brain on Art by Susan Magsamen and Ivy Ross. Your Brain on Art explores the vital role of arts in our lives, beyond mere entertainment. The book reveals a cultural evolution where arts emerge as powerful, accessible solutions for overall well-being. The authors present robust research highlighting the health benefits of art engagement. They illustrate how just 45 minutes of an art activity can significantly reduce stress hormones regardless of skill level, and regular artistic engagement could potentially extend life expectancy by a decade. The book delves into how music fosters cognitive abilities, the therapeutic effects of sound vibrations, the innovative use of virtual reality in therapy, and how interactive art experiences enhance memory and sensory engagement. It also discusses how art is being integrated into medical prescriptions for various health issues like loneliness and dementia. Your Brain on Art serves as a gateway to understanding the intersection of arts, aesthetics, and wellness. It includes discussions with renowned figures like David Byrne, Renée Fleming, and E. O. Wilson, offering a comprehensive view of neuroaesthetics. This guide combines cutting-edge research, multidisciplinary expert insights, and inspirational stories, showcasing how arts significantly improve life quality. ==== 0:00 Intro  3:07 How Susan & Ivy Began Studying Art 9:20 Why Art is Necessary for Humanity  14:22 Your Brain on Art 18:50 How Observing Art Helps Us  20:34 Reducing Amygdala Actions 22:16 The Healing Power of Sound and Vibration  25:18 The Role of Aesthetics & Awe of Nature  32:06 Poetry: the Oldest Art Form  34:48 Treating Mental Illness with Art 40:06 Why Talent Doesn’t Matter 44:14 Creative Flow & Mindfulness 45:34 Theatre & Connecting to Our Emotions 51:04 Psychedelics for Healing 57:30 The Art of Food 1:00:51 Conclusion ==== Susan Magsamen is the founder and executive director of the International Arts + Mind Lab (IAM Lab), Center for Applied Neuroaesthetics, a pioneering neuroaesthetics initiative from the Pedersen Brain Science Institute at Johns Hopkins University School of Medicine. Susan’s work focuses on how the arts and aesthetic experiences measurably change the brain, body and behavior and how this knowledge can be translated to inform health, wellbeing and learning programs in medicine, public health and education.   Magsamen is also the co-author of the New York Times Bestseller, Your Brain on Art: How the Arts Transform Us written for the general public.  === Ivy Ross is the Vice President of Design for the Hardware organization at Google. Over the past six years, she and her team have launched 50+ products winning over 240 global design awards. This collection of hardware established a new Google design aesthetic that is tactile, colorful, and bold. Most recently, Ivy co-authored with SusanMagsamen Your Brain on Art: How the ArtsTransform Us. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

Get up to 53% off the P600 cookware and a FREE set of silicone utensils: https://chefsfoundry.com/DrPerlmutter   🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱   Loneliness is pervasive in our modern world. The sense of isolation and lack of connection, clearly made worse by the COVID pandemic, is associated with a wide scope of health issues and even mortality. So what do we do?   Some important steps are presented in our podcast, an interview with the author of Project Unlonely - Healing Our Crisis of Disconnection, Dr. Jeremy Nobel.   Jeremy Nobel, M.D., MPH, is a primary-care physician, public health practitioner, and award-winning poet with faculty appointments at the Harvard T.H. Chan School of Public Health and the Harvard Medical School. He is the founder and president of the Foundation for Art & Healing (www.ArtandHealing.org), whose signature initiative, Project UnLonely, addressing the personal and public health challenges of loneliness and social isolation, has gained national visibility.   This is an important topic, not just for the elderly, living alone, but for all of us. For it is clear that any of us can feel lonely and disconnected, even in the midst of our busy lives.   ==== TIMESTAMPS: 0:00 Intro 2:10 Our Epidemic of Loneliness 6:11 Leveraging the Creative Arts for Healing 12:21 Evaluating Loneliness in Studies 16:31 How Loneliness Equates to Heightened Disease Risk 19:43 The Loneliness Spiral 21:56 Inflammation 24:38 How World Events Impact Well-Being 26:45 What You Can Do: Art as a Medium for Healing 31:05 How Psychedelics Overlap with Creativity 35:44 Cultural Norms Impact Loneliness 38:31 The Biggest Challenge for Moving Forward 40:57 The Potential of Awe and Nature-Connection 44:24 Correlation Between Loneliness and FMRI Imaging 50:00 Conclusion ====   JEREMY NOBEL, M.D., MPH, is a primary-care physician, public health practitioner, and award-winning poet with faculty appointments at the Harvard T.H. Chan School of Public Health and the Harvard Medical School. He is the founder and president of the Foundation for Art & Healing (www.ArtandHealing.org), whose signature initiative, Project UnLonely, addressing the personal and public health challenges of loneliness and social isolation, has gained national visibility.   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱   Who knew? The same mechanisms that are involved in brain degeneration, cardiovascular disease, and virtually any other chronic degenerative decline that we experience in our bodies is also at play on our bodies, meaning affecting our skin. Yes, free radical mediated stress and inflammation are the pillars of what causes good skin to go bad. So, with that in mind I felt it would be terrific to interview a leader in holistic approaches to skin care and plastic surgery, Dr. Anthony Youn. Let me tell you more about him.   Known as America's Holistic Plastic Surgeon®, Anthony Youn, M.D. F.A.C.S is a nationally-recognized, board-certified plastic surgeon. Recognized as a leader in his field, he is the author of the best-selling books “The Age Fix," "In Stitches," and “Playing God.” His public television special, The Age Fix with Dr. Anthony Youn, has been viewed by millions.  Dr. Youn also hosts the popular podcast The Holistic Plastic Surgery Show.  He is the most followed plastic surgeon on social media, with over 4.5 million subscribers on his YouTube Channel and 8 million followers on TikTok. His new book, “Younger for Life” is a complete holistic guide to turning back the clock using the process of Autojuvenation®.   I learned an awful lot today on this podcast and hope you do too.     ==== TIMESTAMPS: 0:00 Intro 3:00 Dr. Youn’s Wake-up Call From Plastic Surgery 7:05 5 Accelerates for Skin Aging 10:44 What Causes Loss of Collagen 14:59 Healing the Skin Microbiome 17:38 Challenging the Dogma of Plant-Based Collagen 20:24 How to Supplement Collagen 21:29 Skin Cancer, Sun Exposure & Healthy Sunscreens 30:18 How Our Food Choices Cause Skin Inflammation 34:39 Autophagy: Small Steps that Lead to Big Changes 41:03 Botox & Fillers: What You Should Know 43:46 Conclusion ====   Known as America's Holistic Plastic Surgeon®, Anthony Youn, M.D. F.A.C.S is a nationally-recognized, board-certified plastic surgeon. Recognized as a leader in his field, he is the author of the best-selling books “The Age Fix," "In Stitches," and “Playing God.” His public television special, The Age Fix with Dr. Anthony Youn, has been viewed by millions.  Dr. Youn also hosts the popular podcast The Holistic Plastic Surgery Show.  He is the most followed plastic surgeon on social media, with over 4.5 million subscribers on his YouTube Channel and 8 million followers on TikTok. His new book, “Younger for Life” is a complete holistic guide to turning back the clock using the process of Autojuvenation®.   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.