The Long Run with Luke Timmerman

Leslie Williams, CEO of Boston-based hC Bioscience, on developing transfer RNA therapies.

Chris Garcia, a biochemistry professor at Stanford and biotech entrepreneur, dives into the fascinating world of protein engineering for cancer and autoimmune treatments. He shares his transformative journey from aspiring tennis player to leading immunology research. Topics include the ingenious application of AI in protein design, innovative strategies for enhancing clinical trials, and the significance of T-cell interactions in cancer therapies. Personal anecdotes of endurance running cleverly illustrate how these experiences spark creative breakthroughs in science.

Zach Hornby, CEO of San Diego-based Boundless Bio, on tackling cancer drug resistance.

Ted Love, chairman of BIO, and Dr. Alan Anderson, executive director of Sickle Forward, on how to improve quality of life for sickle cell disease patients around the world.

Sarah Boyce, CEO of Avidity Biosciences, shares her inspiring journey from Liverpool to leading a company focusing on RNA medicines for rare muscle diseases. She discusses the innovative therapies being developed for conditions like myotonic dystrophy and Duchenne muscular dystrophy. The conversation dives into the challenges of transitioning to a CEO role and the significance of emotional intelligence in leadership. Boyce also highlights advancements in RNA therapeutics, including promising drug trials and the importance of community engagement in biotechnology.

Sean McClain, CEO of Absci, discusses using AI to speed up biologic drug discovery. Topics include the upcoming clinical testing of an antibody drug for inflammatory bowel disease in 2025, integrating AI into drug discovery, the creative aspects of biologic drug discovery, engineering E. coli for biologic therapies, evolving business models in biologic drug discovery, unexpected discoveries in drug compound affinity, and revolutionizing drug discovery with AI-generated biologics.

Jeff Stein, CEO of San Diego-based Cidara Therapeutics, on a long-lasting drug against flu.

Abe Ceesay, CEO of Boston-based Rapport Therapeutics, on a precision medicine approach to neuroscience drug discovery.

Jimi Olaghere is one of the first patients to have been functionally cured of sickle cell disease with a CRISPR gene-edited cell therapy.

David Younger and Randolph Lopez, co-founders of A-Alpha Bio, discuss using synthetic biology and AI for drug discovery. They explore yeast as a platform, business representation challenges, and innovative approaches to developing antibodies. The podcast dives into how AI revolutionizes drug discovery and optimization, impacting human health through unique biological understanding.