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The Long Run with Luke Timmerman

Ep175: Andy Scharenberg on in vivo CAR-T cell therapies

Mar 16, 2025
Andy Scharenberg, Co-founder and CEO of Umoja Biopharma, is advancing in vivo CAR-T cell therapies to make life-saving treatments more accessible. He talks about the challenges and breakthroughs in CAR T-cell treatments, including the transformative possibilities of gene therapies. Scharenberg reflects on his journey from medicine to molecular innovation and highlights the importance of collaboration in tackling complex immune disorders. He also shares exciting developments aimed at revolutionizing cancer treatment and enhancing patient outcomes.
01:10:46

Podcast summary created with Snipd AI

Quick takeaways

  • Umoja Biopharma is innovating in vivo CAR-T cell therapies to directly target cancer cells, streamlining treatment processes and accessibility.
  • The company aims to revolutionize patient access to CAR-T therapies by implementing a single-session delivery system and cutting-edge technologies.

Deep dives

In Vivo CAR T-Cell Therapy Concept

Umoja Biopharma aims to revolutionize CAR T-cell therapy by developing in vivo treatments that reprogram the immune system to target and destroy cancer cells directly within the body. This approach contrasts with traditional methods requiring time-consuming and expensive ex vivo processes, where T-cells are extracted, modified, and reinfused. By delivering gene therapy in a single session, Umoja hopes to simplify treatment processes, reduce costs, and make these life-saving therapies more accessible to patients. Specifically, the company seeks to address the challenges of current CAR T therapies by allowing patients to quickly receive effective treatments without the need for extensive hospitalizations.

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