
MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
Latest episodes

Jan 21, 2025 • 1h 18min
John King
This week, Christina and Jamie are joined by John King, CNN's chief national correspondent. He shares why he finally decided to stop hiding his MS diagnosis, and they discuss vulnerability, stubbornness, doing the best we can, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis show is sponsored by:AG1 - AG1 is offering new subscribers a FREE $76 gift when you sign up. You’ll get a Welcome Kit, a bottle of D3K2 AND 5 free travel packs in your first box. So make sure to check out DrinkAG1.com/messy Calm - Stress less, sleep more, and live better with Calm. For listeners of our show, Calm is offering an exclusive offer of 40% off a Calm Premium Subscription at calm.com/MESSYSleep Number -Save 50% on the NEW Sleep Number Limited Edition smart bed for a limited time. Exclusively at a Sleep Number® store near you. See store or sleepnumber.com for details.Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. MudWtr - Head to mudwtr.com and grab your starter kit today! Get up to 43% off your entire order, plus free shipping and a free rechargeable frother when you use code MESSY at mudwtr.com

Jan 14, 2025 • 1h 4min
We Love LA
This week, Christina and Jamie share their thoughts on the Los Angeles wildfires, and discuss disclosing disabilities in the workplace, dating with MS, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischLos Angeles Fire Relief Donation Links:LAFD: https://supportlafd.kindful.com/Baby2Baby: https://donate.baby2baby.org/give/648067/#!/donation/checkoutHelping Families Affected by LA Fires Restore Hope (GoFundMe Directory): https://docs.google.com/spreadsheets/d/1pK5omSsD4KGhjEHCVgcVw-rd4FZP9haoijEx1mSAm5c/htmlview?fbclid=PAZXh0bgNhZW0CMTEAAaanyHFQZy6GJ1UjXkRsS7Ekb9uGae9D5n6Ea0JSg-3DMqxdLdo5HVj43_s_aem_UYT3517g3GQjoC_iw0iZ2gThis episode is sponsored by:PelotonSleep NumberBetterhelpEveryday DoseFatty15PurityWoods

Jan 7, 2025 • 1h 13min
How Trauma Gets Stored in the Body with Dr. Scott Lyons
This week, Christina and Jamie are joined by Dr. Scott Lyons, a licensed holistic psychologist, educator, and author. They discuss how trauma gets stored in the body, the survival strategies we create for ourselves, techniques to help calm the nervous system, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:iRestore - Unlock your best skin with @iRestorelaser and save $205 off your iRestore Illumina Face Mask with code MESSY25 at irestorelaser.com/MESSY25! #irestorepodLume. Control Body Odor ANYWHERE with @lumedeodorant and get 15% off with promo code messy at lumepodcast.com/messy! #lumepodHoneylove - Get an additional 20% OFF the @honeylove Holiday sale by going to honeylove.com/messy #honeylovepodBranch Basics - Get 15% off Branch Basics with the code messy at https://branchbasics.com/messy #branchbasicspod

Dec 31, 2024 • 1h 1min
Roses and Thorns
This week, Christina and Jamie reflect on their roses and thorns from the year, and discuss how to handle kids and bullying, the power of words, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:AG1 - AG1 is offering new subscribers a FREE $76 gift when you sign up. You’ll get a Welcome Kit, a bottle of D3K2 AND 5 free travel packs in your first box. So make sure to check out DrinkAG1.com/messy to get this offer! Peloton - Find your push. Find your power with Peloton at onepeloton.com

Dec 24, 2024 • 52min
You Don’t Know What Anyone Else Is Going Through with Jesse Solomon
This week, Christina and Jamie are joined by their first bravolebrity, Jesse Solomon, who is also a two-time testicular cancer survivor. They discuss what it was like being part of “Summer House,” how he dealt with a cancer diagnosis in his twenties, the importance of celebrating life, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Fatty15 - Fatty15 is on a mission to replenish your C15 levels and restore your long-term health.You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/MESSY and using code MESSY at checkout. Whoop - Head to join.whoop.com/messy to get started today with a free one-month trial.

Dec 17, 2024 • 1h 2min
The Permission to Cry
This week, Christina and Jamie read listener letters and discuss being your messiest self, figuring it out as you go, keeping track of the good things, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Peloton - Find your push. Find your power with Peloton at onepeloton.comMudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR at mudwtr.com/messy #mudwtrpodZoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. OneSkin - Get 15% off OneSkin with the code messy at https://www.oneskin.co/ #oneskinpodBetterHelp - This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.Lolavie - Get 15% off LolaVie with the code messy15 at https://www.lolavie.com/messy15 #lolaviepod

Dec 10, 2024 • 1h 13min
Putting Life on Paper with Liz Feldman
This week, Christina and Jamie are joined by Liz Feldman, the creator of “Dead to Me.” They discuss what it was like on set when Christina received her diagnosis, the ebbs and flows of life, loving your inner child, and much more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Lolavie - Get 15% off LolaVie with the code messy15 at https://www.lolavie.com/messy15 #lolaviepod Oak Essentials - Get 15% off @OakEssentials with the code MESSY15 at oakessentials.com/MESSY15. #oakessentialspartnerLume - Control Body Odor ANYWHERE with @lumedeodorant and get 15% off with promo code MESSY at lumepodcast.com/messyHello Fresh - Get 10 FREE meals at HelloFresh.com/freemessy. Applied across 7 boxes, new subscribers only, varies by plan. That’s 10 free HelloFresh meals, just go to HelloFresh dot com slash freemessy.” HelloFresh America’s #1 Meal KitBetterHelp -This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.Whoop - Head to join.whoop.com/messy to get started today with a free one-month trial.

Dec 3, 2024 • 1h 10min
Take a Break and Bravo
This week, Christina and Jamie discuss their holiday traditions, sitting with feelings, believing in miracles, and more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischShop MeSsy Merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/homeThis episode is sponsored by:BetterHelp - This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/messy and get on your way to being your best self.Jenni Kayne - Find your forever pieces @jennikayne and get 15% off with promo code messy15 at jennikayne.com/messy15 #jennikaynepartnerZoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. Whoop - Head to join.whoop.com/messy to get started today with a free one-month trial. iRestore - Unlock your best skin with @iRestorelaser and get 25% off your Illumina Face Mask with the code MESSY25 at irestorelaser.com/messy25 #irestorepodOne Skin - Get 15% off OneSkin with the code messy at https://www.oneskin.co/ #oneskinpod

Nov 26, 2024 • 1h 15min
No Time for Inauthenticity with Amber Lewis
This week, Christina and Jamie are joined by Amber Lewis, founder of Amber Interiors, who is also living with MS. They discuss her dramatic perspective shift, why she’s decided to treat her diagnosis like a gift, being okay with asking for help, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischShop MeSsy Merch: https://messypodcastmerch.giveswagger.com/messy_podcast_merch/shop/homeThis episode is sponsored by:Oak Essentials - Get 15% off @OakEssentials with the code MESSY15 at oakessentials.com/MESSY15. #oakessentialspartnerJenni Kayne - From now through the end of November, shop the @JenniKayne sale and get 25% off at jennikayne.com/messy15 #jennikaynepartnerWhoop - Head to join.whoop.com/messy to get started today with a free one-month trial. Cionic - We’re excited to share that MeSsy listeners can get $50 off by entering the code MESSY during checkout. To learn more, visit cionic.com/messyHoneylove - From now until December 4th, get up to 60% OFF @honeylove by going to honeylove.com/messy #honeylovepodMudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR at mudwtr.com/messy #mudwtrpod

Nov 19, 2024 • 54min
Ball of Trauma
This week, Christina and Jamie discuss the different trauma responses we have, the importance of bedside manner, living minute to minute, medical gaslighting, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis episode is sponsored by:Peloton - Find your push. Find your power with Peloton at onepeloton.comHello Fresh - Get 10 FREE meals at HelloFresh.com/freemessy. Applied across 7 boxes, new subscribers only, varies by plan.Lume - Control Body Odor ANYWHERE with @lumedeodorant and get 15% off with promo code MESSY at LumeDeodorant.com #lumepodMudwtr - Start your new morning ritual & get up to 43% off your @MUDWTR at mudwtr.com/messy #mudwtrpodArticle - Article is offering our listeners $50 off your first purchase of $100 or more. To claim, visit ARTICLE.COM/MESSY and the discount will be automatically applied at checkoutiRestore - Reverse hair loss with @iRestorelaser and save on their biggest offer of the year at irestorelaser.com/messy #irestorepod