In the Know with Amol Sarva
Amol Sarva
Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas
Episodes
Mentioned books
Jul 26, 2024 • 37min
How weight loss works with Yale’s Dr. Waj Mehal
Metabolic Health is the biggest medical breakthrough of the moment
We have one of the world's experts on the liver - the place your body stores lots of energy from food, and distributes it onward to other systems, Dr. Waj Mehal of the Yale School of Medicine.
We lay out a map of the systems in digestion and metabolism, weight loss and exercise -- plus the different pathways that GLP-1s like Ozempic are using, and what else expected or unexpected is going on in our bodies
Jul 25, 2024 • 45min
How Ozempic works and what else could revolutionize metabolic health with James Peyer, Ph.D. of Cambrian Bio
Metabolic Health is the biggest medical breakthrough of the moment
Get up to speed on the cellular biology with a fantastic overview from PhD scientist and founder of breakthrough pharma platform Cambrian Bio
Aug 8, 2023 • 52min
Alex Zhavoronokov from In Silico, the AI longevity drug discovery giant, on the revolution now and tomorrow
Jul 10, 2023 • 47min
Kristen Fortney from a16z-backed BioAge Labs on how they’re reversing the molecular mechanisms of aging
Jul 10, 2023 • 50min
Noah Davidson of Rejuvenate.bio on their gene therapy to reverse aging across the entire system
Jul 10, 2023 • 53min
Joe Betts-Lacroix from Retro.bio on the power of AI to shorten the path to transformative longevity
Jul 10, 2023 • 50min
Matt Kaeberlein on which longevity supplements might really work, and which don’t
Professor Matt Kaeberlein is an outspoken proponent of rapamycin, and pretty skeptical about virtually all the other interventions people talk most about. Here he lays out a pretty complete and persuasive model for why and how aging happens at all, and why some approaches are most likely to work.
Dec 12, 2022 • 39min
Nir Barzilai on the genes of centenarians and some nuance on metformin
A rare MD at the cutting edge of the longevity field, Dr. Barzilai heads the Institute for Longevity Research at Einstein. We cover his unique contributions, especially the currently buzzy topic of metformin, as well as his work on the genetic luck of centenarians.
Dec 12, 2022 • 36min
Jean Herbert on regenerating the brain in the lab
One of the more incredible research programs in longevity is regeneration: rebuilding and replacing failing organs with lab-grown cells. Jean Herbert at Einstein is working on regenerating your brain.
Nov 29, 2022 • 53min
James Peyer from Cambrian Biosciences and Apollo Health Ventures tells us how to play longevity to win
This founder has been part of so many of the exciting longevity startups, investments, and discussions that you simply must understand the world the way he sees it before taking a view about life extension. In this episode, you will.
