In the Know with Amol Sarva
Amol Sarva
Amol Sarva's series with changemakers and innovators in longevity, tech, and ideas
Episodes
Mentioned books
Aug 1, 2024 • 30min
Pro biotics, pre biotics, and what your digestive system knows with Maya Kaelberer, Ph.D.
Let's understand an overlooked dimension of the weight loss revolution underway -- the microbes in the digestive system themselves, potentially where GLP-1s come from in the first place. Duke's gut biome expert Maya Kaelberer gives us a guide.
Metabolic Health is the biggest medical breakthrough of the moment. Dive in!
Jul 31, 2024 • 51min
Metformin, Rapamycin, the cellular mechanisms at the cutting edge of weight loss and longevity with Matt Kaeberlein, Ph.D.
Metabolic Health is the biggest medical breakthrough of the moment
Let's understand the cellular mechanisms and some of the most promising and widely used drugs in the world with one of the foremost researchers in the field, Matt Kaeberlein, formerly of University of Washington and now founder of longevity company Optispan
Jul 30, 2024 • 47min
Bariatric surgery, the gut biome, and the interactions that create weight loss with surgery and nutrition professor Randy Seeley, Ph.D. at Michigan
Metabolic Health is the biggest medical breakthrough of the moment
Mapping all the ways the GLP-1 drugs like Ozempic do and might work means we need to understand the biome and the efficacy of surgical interventions. We talk to Professor Randy Seeley who directs University of Michigan's Nutrition Obesity Research Center
Jul 29, 2024 • 43min
Understanding blood sugar and insulin with world leader on diabetes Dr. John Buse of UNC
Metabolic Health is the biggest medical breakthrough of the moment
Dr. John Buse has been at the forefront of diabetes research and endocrinology since before the first GLP-1 results started to become known. He studies the body's systems that seem to be at the core of how Ozempic and diabetes operate -- let's learn about the endocrine system and map out these system-level interactions
Jul 26, 2024 • 37min
How weight loss works with Yale’s Dr. Waj Mehal
Metabolic Health is the biggest medical breakthrough of the moment
We have one of the world's experts on the liver - the place your body stores lots of energy from food, and distributes it onward to other systems, Dr. Waj Mehal of the Yale School of Medicine.
We lay out a map of the systems in digestion and metabolism, weight loss and exercise -- plus the different pathways that GLP-1s like Ozempic are using, and what else expected or unexpected is going on in our bodies
Jul 25, 2024 • 45min
How Ozempic works and what else could revolutionize metabolic health with James Peyer, Ph.D. of Cambrian Bio
Metabolic Health is the biggest medical breakthrough of the moment
Get up to speed on the cellular biology with a fantastic overview from PhD scientist and founder of breakthrough pharma platform Cambrian Bio
Aug 8, 2023 • 52min
Alex Zhavoronokov from In Silico, the AI longevity drug discovery giant, on the revolution now and tomorrow
Jul 10, 2023 • 47min
Kristen Fortney from a16z-backed BioAge Labs on how they’re reversing the molecular mechanisms of aging
Jul 10, 2023 • 50min
Noah Davidson of Rejuvenate.bio on their gene therapy to reverse aging across the entire system
Jul 10, 2023 • 53min
