ID:IOTS - Infectious Disease Insight Of Two Specialists

Jame and Callum are joined by Vin from Microbe Mail to discuss the management of Difficult to Treat Resistance (DTR) Gram negative infections in South Africa.If you haven't already check out Microbe mail for a high quality infection podcast linking the lab and clinical management.... wait that sounds familiar!Vin is a associate Professor in Clinical Microbiology at the University of the Witwatersrand, Johannesburg, South Africa and a practising clinical microbiologist with the National Health Laboratory Service. She is passionate about microbes (of course), antimicrobial resistance, antimicrobial stewardship, diagnostics, healthcare associated infections, fungal infections, One Health...let's just say it's a very long list!References:Metallo-β-lactamase resistance in Enterobacteriaceae is an artefact of currently utilized antimicrobial susceptibility testing methods Best practices: Appropriate use of the new β-lactam/β-lactamase inhibitor combinations, ceftazidime-avibactam and ceftolozane-tazobactam in South AfricaColistin Monotherapy versus Colistin plus Meropenem Combination Therapy for the Treatment of Multidrug-Resistant Acinetobacter baumannii Infection: A Meta-AnalysisSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Jame and Callum are joined by recent FRCPath Microbiology part 2 exam passers Olly and Rob to discuss how best to prepare for the exam. This is the final exam required to qualify as a medical/clinical microbiologist in the UK. Full revision resources notes available in the linked OneDrive folder below (if you can't access it let us know!). Let us know once you pass!Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Discover a groundbreaking discussion on community-acquired pneumonia treatment, specifically the potential to safely shorten antibiotic use to just three days. The hosts delve into the importance of antibiotic stewardship and compare new findings with traditional eight-day regimens. They examine pneumonia risk scoring systems, advocating for better integration in healthcare. The conversation highlights the challenges of data-driven decision support, emphasizing the need for effective communication in clinical guidelines and practices.

Exploring the nuances of gram positive vs. negative bacteremia, differences in pathogenesis, management, and therapy. Delving into the complexities of bacteremia, immune responses triggered by exotoxins and endotoxins. Optimizing treatment with follow-up cultures and transitioning to oral therapy, including insights from the Sabato trial. Evolution of bacteremia management practices towards personalized treatment.

The rise and fall of Plazomicin reveals the harsh realities of antibiotic development. Explore the financial and regulatory hurdles that inhibit new antibiotic approvals. The innovative subscription model for pharmaceuticals may offer a solution, but what are the implications? Delve into the balance of cost and efficacy in antibiotic selection and the ongoing challenge of antibiotic resistance. The discussion emphasizes the importance of stewardship and invites listener support for reintroducing promising treatments like Plazomicin.

In this episode, the hosts delve into the complexities of urinalysis for UTI diagnosis, discussing the challenges of interpreting test results and the implications of reducing unnecessary tests in healthcare. They highlight the reflex nature of urine analysis, caution against overtreatment of asymptomatic patients, and emphasize the importance of accurate interpretation for optimal patient outcomes.

Join Callum and Jame as they dive into the fascinating world of HACEK organisms, shedding light on their roles in endocarditis. Discover how bacterial strains, dental health, and certain behaviors impact heart health. The duo also navigates complex bacterial classifications, revealing insights into Aggregatobacter to Kingella. Learn about the nuances of diagnosing these infections, the challenges of antibiotic resistance, and the importance of personalized treatment strategies. Prepare for a mix of humor and deep insights into infectious diseases!

Dive into the quirky world of pneumonia as the hosts tackle the challenges of treating atypical pathogens. Discover why standard antibiotics often miss the mark and what alternatives exist. They dissect the nuances of antibiotic prescribing, especially in relation to guidelines. The difference between viral and atypical bacterial infections is explored, revealing critical treatment strategies. Plus, learn how doxycycline can be a game-changer for less severe cases. It’s a fun yet informative journey through infectious disease dilemmas!

Exploring the history, mechanism, spectrum, and toxicity of aminoglycosides. Dive into dosing strategies, penetration, and resistance mechanisms. Discover their role in complex infections and sepsis treatment.

Join the hosts as they unravel the intriguing world of Haemophilus, correcting the myth that Haemophilus influenzae causes the flu. Discover the fascinating history behind its naming and explore various species linked to respiratory infections. Dive into the details of chancroid, the challenges of antibiotic resistance, and the significance of the Hib vaccine in childhood health. The conversation is lively and informative, touching on treatment complexities and the evolving landscape of infectious diseases.