ID:IOTS - Infectious Disease Insight Of Two Specialists

Join Robert Ball, Kelly Bicknell & Rob Read at ECCMID 2023 discussing UTI antibiotic stewardship, CMV & BK infections, responsible publishing in clinical microbiology, and secondary HLH. Topics include challenges in defining UTIs, rapid urine culture processing, managing recurrent UTIs, advancements in transplant infection treatments, AI-generated papers in medical journals, and evolving treatment approaches for HLH.

Callum is reunited with Jame following their separation at ECCMID 2023. Callum shares some highlights including Archaea and their role in human health, Digitalisation within the microbiology lab and the ESCMID/IDSA interviewLinks to publications on Archaea:https://www.moissleichingerlab.com/projects/https://twitter.com/chmoei?lang=enDigitalisation and machine learning in microbiology presentation link: https://appliedmicrobiologyresearch.net/en/blog/keynote-by https://twitter.com/AppliedMicrobi2?s=20Carlos del Rio, president of the IDSAhttps://twitter.com/CarlosdelRio7?s=20Send us a textSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

This podcast explores the basics of beta-lactamase inhibitors, including their targets and classification. It discusses specific inhibitors like clavulanic acid and newer ones like Avabactam. The selection and use of inhibitors for different beta-lactamase enzymes are also covered, including the combination of Astraenam and Avobactam for hydrolysis treatment.

Jame and Callum are joined by the one and only Sara Dong of Febrile fame to look at the American Board of Internal Medicine's Infectious Disease Certification Exam. Send us a textSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Jame and Callum are joined by semi-recent FRCPath Microbiology part 1 exam passers Callum and Jame to discuss how best to prepare for this exam. This exam is sat by all infection trainees in the UK, as well as other health care professionals working in infection such as clinical scientists. Full revision resources notes available in the linked OneDrive folder below (if you can't access it let us know). Let us know once you pass! (Disclaimer: previous sentence for engagement purposes only, please do not let us know once you pass). Send us a textSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Jame and Callum are joined by Vin from Microbe Mail to discuss the management of Difficult to Treat Resistance (DTR) Gram negative infections in South Africa.If you haven't already check out Microbe mail for a high quality infection podcast linking the lab and clinical management.... wait that sounds familiar!Vin is a associate Professor in Clinical Microbiology at the University of the Witwatersrand, Johannesburg, South Africa and a practising clinical microbiologist with the National Health Laboratory Service. She is passionate about microbes (of course), antimicrobial resistance, antimicrobial stewardship, diagnostics, healthcare associated infections, fungal infections, One Health...let's just say it's a very long list!References:Metallo-β-lactamase resistance in Enterobacteriaceae is an artefact of currently utilized antimicrobial susceptibility testing methods Best practices: Appropriate use of the new β-lactam/β-lactamase inhibitor combinations, ceftazidime-avibactam and ceftolozane-tazobactam in South AfricaColistin Monotherapy versus Colistin plus Meropenem Combination Therapy for the Treatment of Multidrug-Resistant Acinetobacter baumannii Infection: A Meta-AnalysisSend us a textSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Jame and Callum are joined by recent FRCPath Microbiology part 2 exam passers Olly and Rob to discuss how best to prepare for the exam. This is the final exam required to qualify as a medical/clinical microbiologist in the UK. Full revision resources notes available in the linked OneDrive folder below (if you can't access it let us know!). Let us know once you pass!Send us a textSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

It's time for journal club! Jame and Callum discuss community acquired pneumonia treatment and a paper from 2021 which examines shorter duration therapy for patients responding to therapy.Paper discussed:Dinh, Aurélien et al. “Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial.” Lancet 2021;397: 1195-1203. doi:10.1016/S0140-6736(21)00313-5Shorter is Better site:https://www.bradspellberg.com/shorter-is-betterSend us a textSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Exploring the nuances of gram positive vs. negative bacteremia, differences in pathogenesis, management, and therapy. Delving into the complexities of bacteremia, immune responses triggered by exotoxins and endotoxins. Optimizing treatment with follow-up cultures and transitioning to oral therapy, including insights from the Sabato trial. Evolution of bacteremia management practices towards personalized treatment.

This Christmas, Jame shares a tale of woe: the rise and fall of Plazomicin, a hapless victim of antibiotic market forces. The conversation then proceeds/degenerates into a discussion of the economics of Antimicrobials in general, with a focus on the ‘Netflix’ model being piloted in the UK.  WE’LL BE BACK NEXT YEAR SEE YOU THENSend us a textSupport the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.socialPrep notes for completed episodes can be found here (Not all episodes have prep notes).If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod