Immune

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Genetic variation in laboratory mice (Immunity) Time stamps by Jolene. Thanks! Vaccines and Your Child Letters read on Immune 23 Weekly Science Picks Steph- University of Alaska budget crisis Cindy- 90% survival following new Ebolavirus treatments Vincent- Immunology videos at Blausen Medical Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Engineering B cells to produce antiviral antibodies (Sci Immun) Time stamps by Jolene. Thanks! Letters read on Immune 22 Weekly Science Picks Steph- Breath of fresh air Cindy- Biologist found dead Vincent- Nobel Prizes and Nature’s Surprises by Erling Norrby Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Unique Scientists Cindy- Researcher app Vincent- STLR Conversations Podcast Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.   Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Inflammasome activation triggers blood clotting (Immunity) Rotavirus and Nlrp9b inflammasome (Nature) Societal Amnesia and vaccines by Cindy Leifer Image credit Letters read on Immune 20 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- iBiology Immunology Course Cindy- Changing vaccine hesitancy Vincent- Bad Advice by Paul Offit (and Vaccines and Your Child) Listener Pick Steve- An Elegant Defense Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.   Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Maternal immunization protects offspring (Sci Trans Med) Diversity of herpesvirus in neonates (TWiV 540) Mariana Mazzucato on Freakonomics Letters read on Immune 19 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- iNaturalist Cindy- Taking a break is also hard work Vincent- Immunology Wall Posters Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Trogocytosis for T cell antigen discovery (Nat Methods) Trogocytosis (J Immunol) Orphan T cell receptors (Cell) Letters read on Immune 18 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Scientists rise up against statistical significance Cindy- Why I quit my PhD and returned Vincent- The Law and Vaccine Resistance Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Darwin Day Metabolic rewiring of macrophages by CpG (Nat Immunol) Letters read on Immune 17 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Pregnant Scholar Cindy- Anti-vaxxers vaccinating against measles Vincent- Center for Science in the Public Interest Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Role of B cells in Marek's disease pathogenesis (PNAS) In ovo vaccination (YouTube) First chickens lacking B cells (PNAS) Letters read on Immune 16 Time stamps by Jolene. Thanks! Weekly Science Picks Steph - 7 Days Out Cindy - Watson PBS documentary and Cold Spring Harbor Laboratory response Vincent - Dads can donate mitochondrial DNA and Chicken puns

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Slings enable neutrophil rolling (Nature) Sling video (La Jolla Inst Allergy Immunol) Neutrophil extracellular traps kill bacteria (Science) Neutrophil review (Sci Immunol) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Should reviewers remain anonymous? Cindy- Breast Cancer Research Foundation Vincent- Initiative to End Paywalls (The Scientist) Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode 2018 Nobel Prize in Medicine 2018 Nobel Prize in Medicine (pdf) What's in a name?(Can Res Inst) Checkpoint inhibitor failures(Nature) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Immunobites Cindy- List of immunology Nobels Vincent- Prof. Barker's Immunology lectures Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv