The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Potent anti-RSV antibodies without somatic hypermutation (Immunity) History of vaccine enhanced RSV disease (Clin Vacc Immunol) Image credit Letters read on Immune #6 Weekly Science Picks Steph - REACTOME project (free icons) Cindy - Gender Imbalance in Stories Vincent - Trump, Tell Us About Your Flu Shot Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Food Allergy(Nat Rev Dis Prim) Maternal allergen sensitization(J Exp Med) Image credit Letters readon Immune #5 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) Engineering immune cells to treat cancer (Cell) Engineering T cells for fungal infections (PNAS) CAR T cells for AIDS (PLoS Path) CAR T cells (NIH) Image credit Letters read on Immune #4 Weekly Science Picks Cindy - What's In A Name? Steph - Novel Targets Vincent - Friendly Penguin Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Model for dengue ADE (Scitable) Dengue ADE in humans (Science) Dengvaxia discussion (TWiV 471) Bi-specific antibody to Zika virus (Cell) Building Zika Virus Letters read on Immune #3 Weekly Science Picks Cindy - Questions answered about starving polar bear video Steph - Deep Work by Cal Newport and Grad Student Tax Vincent - Making art with Excel Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Circadian clocks control lymphocyte trafficking (Immunity) Lymph node image credit Letters read on Immune #2 Weekly Science Picks Cindy - Men ask more questions than women at a scientific conference (PLoS One) Steph - House just voted to bankrupt graduate students Vincent - Trump's Legacy: Damaged Brains Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Leifer Lab at Cornell Stephanie Langel Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res) Fever regulates immunity (Nat Rev Immunol) Macrophage image by Blausen Medical Weekly Science Picks Cindy - FDA approves second CAR T cell therapy Steph - Gammaherpesvirus protects against asthma Vincent - Truth Wins by Jonathan Yewdell Intro music is by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv