Immune

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode ACE2 in oral mucosa (I J Oral Sci) IL6 predictor of COVID-19 death (Int Care Med) Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv) Antibody to SARS-CoV wanes (J Immunol) Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Irene Salinas Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Evolution of mucosal Ig in rainbow trout (Sci Immunol) Fish olfactory neurons mediate rapid immune response (PNAS) Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode H3K4me1 mark on memory-like NK cells (Cell Rep) Letters read on Immune 27 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Michael Mina Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Measles virus infection diminishes pre-existing antibodies (Science) Public epitope #1 (TWiV 342) Incomplete reconstitution of B cell pools after measles (Sci Immunol) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8+ T cell memory needs microbiome derived fatty acids (Immune) Image credit: Principles of Virology 4e Time stamps by Jolene. Thanks! Letters read on Immune 25 Weekly Science Picks Stephanie - This Week in Neuroscience Cindy - Graduate Abuse by Derek Lowe Vincent - Funding ends for seeking new viruses Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode New type of T helper cell drives anaphylaxis (Science) Image credit Time stamps by Jolene. Thanks! Letters read on Immune 24 Weekly Science Picks Cindy- Lasker Award 2019 Vincent- Eleanor's Breakthrough video Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Genetic variation in laboratory mice (Immunity) Time stamps by Jolene. Thanks! Vaccines and Your Child Letters read on Immune 23 Weekly Science Picks Steph- University of Alaska budget crisis Cindy- 90% survival following new Ebolavirus treatments Vincent- Immunology videos at Blausen Medical Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Engineering B cells to produce antiviral antibodies (Sci Immun) Time stamps by Jolene. Thanks! Letters read on Immune 22 Weekly Science Picks Steph- Breath of fresh air Cindy- Biologist found dead Vincent- Nobel Prizes and Nature’s Surprises by Erling Norrby Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Unique Scientists Cindy- Researcher app Vincent- STLR Conversations Podcast Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.   Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Inflammasome activation triggers blood clotting (Immunity) Rotavirus and Nlrp9b inflammasome (Nature) Societal Amnesia and vaccines by Cindy Leifer Image credit Letters read on Immune 20 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- iBiology Immunology Course Cindy- Changing vaccine hesitancy Vincent- Bad Advice by Paul Offit (and Vaccines and Your Child) Listener Pick Steve- An Elegant Defense Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv