The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Role of B cells in Marek's disease pathogenesis (PNAS) In ovo vaccination (YouTube) First chickens lacking B cells (PNAS) Letters read on Immune 16 Time stamps by Jolene. Thanks! Weekly Science Picks Steph - 7 Days Out Cindy - Watson PBS documentary and Cold Spring Harbor Laboratory response Vincent - Dads can donate mitochondrial DNA and Chicken puns

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Slings enable neutrophil rolling (Nature) Sling video (La Jolla Inst Allergy Immunol) Neutrophil extracellular traps kill bacteria (Science) Neutrophil review (Sci Immunol) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Should reviewers remain anonymous? Cindy- Breast Cancer Research Foundation Vincent- Initiative to End Paywalls (The Scientist) Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode 2018 Nobel Prize in Medicine 2018 Nobel Prize in Medicine (pdf) What's in a name?(Can Res Inst) Checkpoint inhibitor failures(Nature) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Immunobites Cindy- List of immunology Nobels Vincent- Prof. Barker's Immunology lectures Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Host lncRNA binds RIG-I (Cell) Microbe Art at virology blog Letters read on Immune 13 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- That's Pediatrics Podcast Cindy- Trilobite Glassworks Vincent- Research!America Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Immune system development in newborns (Cell) Dead parrots and live wildcats (TWiV 185) Pathogenesis card game (JAMA) Letters read on Immune 12 Weekly Science Picks Steph- Kaleidoscopean Cindy- 500 women scientists Vincent- NIH budget increase 2019 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts: Vincent Racaniello and Cynthia Leifer Become a patron of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent- Unpaywall Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Rebecca Lynch Become a patron of Immune! Links for this episode Lynch Laboratory Immune merchandise Image credit Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Lamprey VLR responseto influenza virus (eLife) VLR-basedimmunity (Ann Rev Immunol) How the Immune System Works A Commotion in the Blood Immune merchandise Image credit Letters readon Immune 9 Weekly Science Picks Steph- Jon Yewdell on TWiV (208, 467) Cindy- No polio in Venezuela Vincent- Is gaming addiction a thing? Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode γδ17 T cells, T cell homeostasis and thermoregulation (Nat Immunol) γδ17 T cells cells at epithelial barriers(Nat Rev Immunol) Image credit Letters readon Immune 8 Weekly Science Picks Steph- Polycystic ovary syndrome and anti-Mullerian hormone Cindy- Foldscope(Ted talk) Vincent- Virology Lectures 2018 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's(Science) Superresolution structured illumination microscopy Image credit Weekly Science Picks Steph- Social Media for Social Change in Scienceand Structured Illumination Microscopy video Cindy- 314 Action Vincent- Making American great again requires acting on scientific knowledge Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv