Immune

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Reflections of a COVID-19 long hauler (JAMA) Not a cytokine storm in COVID-19 (JCIO) Letters read on Immune 39 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Sallie Permar Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Immune correlates of protection against CMV (J Inf Dis) Placental IgG transfer in HIV-1-infected women (Cell) Immunization leads to HIV-1 antibody in breast milk (J Virology) Lessons from COVID-19 in children (Clin Inf Dis) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guests: Alexis Mobley, Joel Babdor, Elaine Kouame, Justine Noel, Evonne Jean Become a patron of Immune! Links for this episode Black in Immuno Black in Immuno week schedule Systemic racism in higher education (Science) Black in Microbiology (TWiM 228) Black in Virology (TWiV 672) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Alexander Dent Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Loss of germinal centers in severe COVID-19 patients (Cell) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv  

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode COVID-19 severity linked to antibody levels (bioRxiv) Review of antibody mediated immunity to coronaviruses (Nat Comm) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Cross-reactive coronavirus CD4+ T cells (Science) Immune misfiring in severe COVID-19 (Nature) A COVID-19 riddle for the immune system (Nature) Letters read on Immune 34 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8 cells defend against SARS-CoV (J Virol) Deep immune profiling of COVID-19 patients (Science) Letters read on Immune 33 Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Keep CoV off campus (NY Times) Inflammatory cytokines predict COVID-19 death (medRxiv) Imbalanced host response drives COVID-19 (Cell) Convergent antibody responses in COVID-19 patients (bioRxiv) Cross neutralization of SARS-CoV-2 by SARS-CoV mAb (Nature) Human T-cell responses to SARS-CoV-2 (Cell) DNA vaccine protects rhesus macaques (Science) Replicon RNA vaccine protects macaques (bioRxiv) Letters read on Immune 32 Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode How long will a vaccine really take? (NYTimes) Humoral immunity in NYC COVID-19 patients (medRxiv) D614G is just a SNP (TWiEVO 55) Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode IL6 as COVID-19 marker for severity (Med Mal Infect) How does COVID-19 kill? (Nature) SARS-CoV-2 protective immunity in macaques (bioRxiv) SARS antibody titers wane (J Immunol) Vaccine roundup (Lab Equip) Lung IgG in SARS injury (JCI Insight) Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv