Immune

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Host lncRNA binds RIG-I (Cell) Microbe Art at virology blog Letters read on Immune 13 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- That's Pediatrics Podcast Cindy- Trilobite Glassworks Vincent- Research!America Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Immune system development in newborns (Cell) Dead parrots and live wildcats (TWiV 185) Pathogenesis card game (JAMA) Letters read on Immune 12 Weekly Science Picks Steph- Kaleidoscopean Cindy- 500 women scientists Vincent- NIH budget increase 2019 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts: Vincent Racaniello and Cynthia Leifer Become a patron of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent- Unpaywall Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Rebecca Lynch Become a patron of Immune! Links for this episode Lynch Laboratory Immune merchandise Image credit Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Lamprey VLR responseto influenza virus (eLife) VLR-basedimmunity (Ann Rev Immunol) How the Immune System Works A Commotion in the Blood Immune merchandise Image credit Letters readon Immune 9 Weekly Science Picks Steph- Jon Yewdell on TWiV (208, 467) Cindy- No polio in Venezuela Vincent- Is gaming addiction a thing? Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode γδ17 T cells, T cell homeostasis and thermoregulation (Nat Immunol) γδ17 T cells cells at epithelial barriers(Nat Rev Immunol) Image credit Letters readon Immune 8 Weekly Science Picks Steph- Polycystic ovary syndrome and anti-Mullerian hormone Cindy- Foldscope(Ted talk) Vincent- Virology Lectures 2018 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's(Science) Superresolution structured illumination microscopy Image credit Weekly Science Picks Steph- Social Media for Social Change in Scienceand Structured Illumination Microscopy video Cindy- 314 Action Vincent- Making American great again requires acting on scientific knowledge Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Potent anti-RSV antibodies without somatic hypermutation (Immunity) History of vaccine enhanced RSV disease (Clin Vacc Immunol) Image credit Letters read on Immune #6 Weekly Science Picks Steph - REACTOME project (free icons) Cindy - Gender Imbalance in Stories Vincent - Trump, Tell Us About Your Flu Shot Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Food Allergy(Nat Rev Dis Prim) Maternal allergen sensitization(J Exp Med) Image credit Letters readon Immune #5 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) Engineering immune cells to treat cancer (Cell) Engineering T cells for fungal infections (PNAS) CAR T cells for AIDS (PLoS Path) CAR T cells (NIH) Image credit Letters read on Immune #4 Weekly Science Picks Cindy - What's In A Name? Steph - Novel Targets Vincent - Friendly Penguin Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv