Popular guests

Psychologist and leading researcher on women's hormones. Author of 'This Is Your Brain on Birth Control'.

Nobel laureate trade economist and former New York Times Opinion columnist. Currently writes a newsletter on Substack.

Friend of Patrick O'Shaughnessy, embarking on a 40-day and 40-night stay in the African wilderness. Shares his experiences through daily audio recordings.

Co-founder and CEO of Airbnb, known for navigating the company through the pandemic and leading it to a successful IPO.

Professor emeritus in food science and human nutrition. Researches protein and amino acids for muscle health.

Physician and lipidologist. Known for expertise in lipoprotein metabolism and cardiovascular disease prevention.

Bloomberg reporter covering media and entertainment, invited as the episode's guest to discuss the Taylor Sheridan deal and its implications for Hollywood and streaming.

Host of The Cognitive Revolution podcast. Interviews AI builders and researchers.

Author and thinker who wrote Wanting, a book on mimetic desire; discusses how imitation shapes our wants and practices for reclaiming deeper, value-aligned desires.

Ph.D. specializing in optimizing muscle protein synthesis. The discussion is based on podcast #299 with Luc van Loon.

Researcher at OpenAI, leads the core models team on post-training.

World-renowned breathwork pioneer known as the “Iceman”. He developed the Wim Hof Method, which harnesses the transformative power of breath, cold exposure, and commitment.

Journalist and author, contributing writer to the New York Times Magazine. Examines the diagnosis and treatment of ADHD in a recent article.

Serial entrepreneur and co-founder of Method, Welly, and Olly. Currently building a functional candy brand called Tandy.

Built his fortune in energy trading and now applies analytical rigor to philanthropy through Arnold Ventures. Known for his success as an energy trader and his focus on evidence-based philanthropy.

Chief Investment Officer at Fundstrat Capital and Head of Research at FSInsight. He is known for his market insights and predictions.

Host and producer of The Proof podcast who guides conversations on health, mindset and performance; leads interviews and sponsors segments throughout the episode.

Writer and thinker with a background in technology and entrepreneurship (references in the episode include early tech work such as DivX); speaks about sense‑making, culture, and practical origins of his perspectives.

Grammy, Emmy, and Oscar-winning musician. Known for his versatile musical talent and his work on The Late Show with Stephen Colbert.

Tao Professor of Physics and Astronomy at Barnard College of Columbia University. Theoretical cosmologist and Director of Sciences at Pioneer Works in Brooklyn.

Geopolitical strategist and founder of Zeihan on Geopolitics. Provides analysis on global trends, trade, security, and demographics for companies and governments.

Evolutionary biologist and co‑host of the DarkHorse Podcast, contributing scientific perspective and commentary on culture, politics, and natural history.

Founder of an online auction site for internet domains. He has hosted over $100M worth of auctions.

Spiritual teacher and author leading the Essential Teachings podcast; discusses presence, awakening, and transforming suffering into consciousness.

Serial entrepreneur and business ideas enthusiast. Host of The Koerner Office podcast, where he shares business ideas, growth hacking tips, and startup advice.

CEO and founder of Gumroad, a platform that helps creators sell products directly to their audiences. He is at the forefront of using AI to transform product development and coding practices.

Journalist, author, and digital‑rights advocate known for writing about technology and policy; guest discussing platform decline and his book In Shittification.

Entrepreneur and operator who scales businesses and shares lessons on building high-growth companies; host of the Build with Leila Hormozi podcast offering practical career and business advice.

Professor of philosophy at Durham University. Known for defending panpsychism, the view that consciousness is a fundamental and ubiquitous feature of the physical world.

AI engineer, educator, and author who has worked on NVIDIA's NeMo platform, researched at Netflix, taught machine learning at Stanford, and wrote the book AI Engineering.

Lead engineer and self-described “dictator of AMP” at Sourcegraph, focused on building AMP Code and fast iteration practices for coding agents.

Founder of OpenExO and a regular contributor to the podcast.

Board-certified gastroenterologist and ZOE’s U.S. Medical Director. New York Times bestselling author with extensive clinical experience in treating patients suffering from IBS.

Professor of Cosmology at UC San Diego, providing expert commentary on the Big Bang theory and recent James Webb Space Telescope findings.

Host of The Jefferson Fisher Podcast, focusing on communication strategies. Author of The Next Conversation.

YouTube strategist behind 10 billion views annually on YouTube. Provides behind-the-scenes insights on how top-performing videos come to life.

General Partner at Benchmark, a venture capital firm. He co-hosts the BG2Pod, providing expertise on tech, markets, and the investment landscape.

Clinical psychologist and New York Times bestselling author with over 30 years of experience helping adult children heal from emotionally immature parents. She is a pioneering expert on the topic of emotionally immature parents.

Journalist at Semaphore and friend of the pod. He is the author of the article about group chats in Silicon Valley.

James S. Riepe University Professor at the University of Pennsylvania with appointments in Neuroscience, Psychology, and Marketing. Serves as Director of the Wharton Neuroscience Initiative and is a leading voice in neuroeconomics.

Partner at Sequoia Capital and a leading AI investor with prior experience at Coatue; known for investments in AI and defense-related startups such as Clay, Juicebox, Sesame, Kela, Stark, Notion, and Hugging Face.

Host of the podcast, shares ten mental models for learning.

Founder of Koniver Wellness, specializing in performance medicine and natural hormone management protocols.

Comedian, writer, and producer. Host of the Good For You podcast and currently touring nationwide with her stand-up show, Big Baby.

Researcher on Michelle's team at OpenAI, working on post-training.

CEO of GitHub since 2021, leading the company's growth and commitment to developer experience and AI integration.

New York Times bestselling author of The $100 Startup, Side Hustle, and Time Anxiety: The Illusion of Urgency and a Better Way to Live. Visited every country in the world before his thirty-fifth birthday.

Spotify's co-president, chief technology officer, and chief product officer. Expert in AI and its applications in the music and podcast industries.

Co-host of Propane Fitness, contributing to the conversation with personal anecdotes and insights.

Professional bodybuilder and YouTuber known for his vlogs about fitness, nutrition, and bodybuilding. Gained popularity for his authentic and transparent approach to sharing his fitness journey.